ClinicalTrials.gov Studies

Phase 2 FAPI-74 PET/CT Inflammatory Disorders Study

NIH registered Phase 2 clinical trial NCT07535554 to evaluate [18F]-AlF-FAPI-74 PET/CT diagnostic performance in three inflammatory disorder cohorts: fever of unknown origin, IgG4-related disease, and axial spondyloarthritis. The study will compare the new radiopharmaceutical against standard-of-care [18F]-FDG PET/CT imaging.

Insulin Insitu-Gel for Tympanic Membrane Perforations: Early Phase 1 RCT

NIH ClinicalTrials.gov registered Early Phase 1 trial NCT07535827 evaluating insulin insitu-gel formulation for tympanic membrane perforation healing. The randomized controlled study at Minia University Hospital enrolled participants from January 2025 to March 2026, comparing insulin insitu-gel (Humulin with chitosan, polyvinyl alcohol, and Pluronic F127) against foam control. Primary outcome was perforation healing at 1-week, 1-month, and 2-month follow-ups; secondary outcomes included hearing scores. Results showed significantly superior healing in the insulin group versus control.

Effects of Dual-Task Training on Upper Extremity Function in Parkinson's Disease

NIH has registered a clinical trial (NCT07536542) on ClinicalTrials.gov to study the effects of dual-task training on upper extremity function and muscle thickness in individuals with Parkinson's disease. The randomized controlled trial will enroll approximately 60 participants who will be assigned to either an 8-week dual-task training group (3 days per week) or a control group receiving routine care. Researchers will assess upper extremity function, grip strength, pinch strength, and muscle thickness via ultrasonography at baseline and post-intervention.

EUS-RFA for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumors

NIH ClinicalTrials.gov has registered a clinical trial (NCT07536087) evaluating endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) as a treatment for pancreatic cystic neoplasms and pancreatic neuroendocrine tumors in patients ineligible for or refusing surgery. The primary endpoints assess technical feasibility and effectiveness, while secondary objectives evaluate safety and long-term efficacy including adverse events and disease progression over one year of follow-up.

Observational Study, Adolescent Rights, Rural Assiut, Egypt

NIH registered observational study NCT07536555 on ClinicalTrials.gov, titled 'Adolescent Rights Fulfilment in Rural Assiut, Egypt'. The community-based cross-sectional study will assess fulfilment of adolescent rights in health, education, protection, and community participation among 300 adolescents aged 15-19 years in Beni Adi village, Assiut Governorate. Data collection is anticipated to begin April 17, 2026.

Mirror Therapy for Complex Regional Pain Syndrome in Post-Stroke Patients

The NIH ClinicalTrials.gov registry has registered a clinical trial (NCT07537465) evaluating mirror therapy for complex regional pain syndrome in post-stroke patients. The randomized controlled trial will compare mirror therapy to sham mirror therapy over 4 weeks. Participants will receive conventional rehabilitation therapy and be assessed using clinical scales, electrophysiological tests, and ultrasonographic measurements.

Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in Follow-Up of Colorectal Carcinoma

NIH ClinicalTrials.gov registered observational study NCT07536321 evaluating the diagnostic and prognostic value of 18F FDG PET-CT imaging in the follow-up of patients with Stage III rectal cancer. The 5-year prospective study will enroll participants already undergoing routine PET-CT imaging and assess whether PET-CT contributes to treatment decision-making in colorectal cancer patients.

Becotatug Vedotin Phase 2 Hepatocellular Carcinoma Study

NIH registered a Phase 2 clinical trial (NCT07536789) for Becotatug vedotin (MRG003) in previously treated advanced hepatocellular carcinoma (HCC). The study will evaluate efficacy and safety of MRG003 as an intervention. No compliance obligations or deadlines are imposed by this registration.

Effect of Sildenafil on Left Ventricular Function in Pediatric Primary Dilated Cardiomyopathy

NIH registered observational study NCT07536880 titled 'Effect of Sildenafil on Left Ventricular Function in Pediatric With Primary Dilated Cardiomyopathy.' The study examines sildenafil's effect on left ventricular function in pediatric patients with primary dilated cardiomyopathy, characterized by left ventricular dilation and impaired contraction. The study was registered on April 17, 2026.

Arterial Vascular Effects of Estetrol-drospirenone Combined Oral Contraceptive Pill

The NIH registered a Phase 3 clinical trial (NCT07536763) comparing estetrol-drospirenone combined oral contraceptive pills against ethinylestradiol-levonorgestrel pills. The trial will evaluate effects on arterial vascular function including flow-mediated dilatation and pulse wave velocity, blood pressure, inflammatory markers, and metabolic indices over 12 months. Participants are randomized to receive either treatment with clinic visits at baseline, 6 months, and 12 months.

Proton vs Photon IMRT Toxicity in Breast Cancer (NCT07537712)

NIH registered clinical trial NCT07537712, an observational study comparing acute and long-term toxicities between intensity-modulated proton therapy (IMPT) and intensity-modulated photon radiotherapy (IMRT/VMAT) in postoperative breast cancer patients. The study will follow eligible patients for at least one year to assess incidence and severity of toxicities affecting the heart, lungs, skin, esophagus, thyroid, and lymphatic tissues, as well as patient-reported outcomes, cosmetic outcomes, and quality of life. The trial has an estimated completion date of April 17, 2026.

Comparison of Effectiveness of Autobrush vs Manual Toothbrush, Children 9-12

The NIH National Library of Medicine registered clinical trial NCT07537803, a randomized crossover study comparing the effectiveness of an Autobrush U-shaped toothbrush versus a manual regular toothbrush in children aged 9-12 years. The study will measure Full Mouth Plaque Scores using disclosing tablets and assess both brushing techniques. Participants avoid oral cleaning procedures 12 hours before appointments.

Radiofrequency Versus Cervical Fusion for Chronic Whiplash Observational Study

The NIH ClinicalTrials.gov registry has published registration details for NCT07535515, an observational study comparing cervical medial branch radiofrequency ablation versus anterior cervical discectomy and fusion (ACDF) for chronic post-traumatic whiplash patients. The retrospective study reviews medical records from a tertiary hospital spanning 2005-2025 to evaluate pain relief, functional disability, psychological symptoms, and need for repeat procedures.

0.01% and 0.025% Atropine Eye Drops Combined With Auricular Acupoint Stimulation for Myopia Control in Children

NIH has registered a randomized, double-blind, placebo-controlled pilot trial (NCT07537166) evaluating low-dose atropine (0.01%, 0.025%) combined with auricular acupoint stimulation for myopia control in 420 children aged 6-12. Participants will be divided into six groups receiving different treatments or placebo over a 12-week follow-up period. The study aims to determine synergistic effects of combined therapy and establish safer treatment options for myopia, addressing corneal toxicity concerns associated with higher 0.05% atropine concentrations.

Support Group Curriculum for Parents of Children With DLD

NIH registered clinical trial NCT07536217 titled 'Developmental Pilot of Support Groups for Caregivers of Children With DLD' to test a new support group curriculum designed for parents of children with Developmental Language Disorder. The study will evaluate support groups as the intervention approach for this population.

BCD-261 Phase 1 Study, Healthy Chinese Volunteers

NIH ClinicalTrials.gov registered a Phase 1 study for investigational drug BCD-261, a single subcutaneous injection, to evaluate safety, pharmacodynamics, pharmacokinetics, and immunogenicity in healthy adult Chinese volunteers. The study (NCT07535775) represents early-stage clinical research.

Comparative Efficacy of Topical Clotrimazole Versus 2% Salicylic Acid in Otomycosis

NIH has registered a randomized controlled clinical trial (NCT07535424) comparing clotrimazole ear drops versus 2% salicylic acid ear drops for treatment of otomycosis (fungal ear canal infection). The study enrolled 60 patients randomized equally between the two treatment groups, with both interventions administered three times daily for two weeks. The primary outcome measure is relief of ear blockage reflecting improvement in canal patency.

Fontan Outcomes in Oligemia vs Plethora in Univentricular CHD

NIH registered a prospective cohort study (NCT07535203) comparing Fontan procedure outcomes in patients with cyanotic congenital heart disease classified by pulmonary blood flow characteristics. Fifty-two patients will be divided into oligemia and plethora groups and followed for approximately 1.5 years post-procedure to assess mortality, morbidity, pulmonary hemodynamics, functional capacity, neurocognitive status, and quality of life.

Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients

NIH registered observational study NCT07537621 examining right ventriculo-arterial coupling during fluid loading in ICU patients. The study investigates the relationship between preload responsiveness, venous congestion, and right ventricular function in critically ill patients with shock and right ventricular dysfunction. Echocardiography will be used as the primary intervention to assess hemodynamic changes.

EXTEND-TNK Registry, IV Tenecteplase, Acute Ischemic Stroke, China

The NIH ClinicalTrials.gov has registered NCT07536165, the EXTEND-TNK Registry, a prospective multicenter observational cohort study evaluating intravenous tenecteplase administered beyond 4.5 hours after last known well for acute ischemic stroke patients in routine clinical practice across China.

Early Delirium Prediction Via Serial EEG Trajectories and Machine Learning

NIH registered observational study NCT07536854 on ClinicalTrials.gov. The study aims to develop a machine learning model predicting delirium in trauma ICU patients using serial EEG recordings. Researchers will analyze brainwave patterns across recording conditions to identify early delirium biomarkers before clinical onset.

Firsekibart, Tislelizumab, Lenvatinib for TP53-Mutated HCC

NIH registered Phase 2 clinical trial NCT07535840 evaluating combination therapy with Firsekibart, Tislelizumab, and Lenvatinib in patients with unresectable, TP53-mutated hepatocellular carcinoma who have failed prior systemic immunotherapy. The study's primary objective is objective response rate, with secondary objectives assessing overall efficacy, safety, and biomarker predictors.

GALLVIA Trial: EUS-Guided vs Transpapillary Gallbladder Drainage for Acute Calculous Cholecystitis

NIH registered the GALLVIA Trial (NCT07536191), a multicenter randomized controlled trial comparing endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) with endoscopic transpapillary gallbladder drainage (EGBS) in poor surgical candidates with acute calculous cholecystitis. The 1:1 randomized trial uses lumen-apposing metal stents for EUS-GBD and transpapillary plastic stents for EGBS, with primary endpoint of clinical success. Secondary endpoints include technical success, adverse events, reintervention rate, procedure time, length of stay, and 30-day mortality.

Neural Mobilization vs Cervical Neuromodulation in Diabetic Peripheral Neuropathy: Randomized Pilot Trial, 75 Participants

NIH registered a three-arm, assessor-blinded randomized controlled pilot feasibility trial (NCT07537270) comparing Manual Neural Mobilization and Cervical Neuromodulatory Intervention against standard care in 75 participants with diabetic peripheral neuropathy over 12 weeks. The primary endpoints are recruitment rates, adherence, and safety; secondary endpoints include HbA1c, fasting blood glucose, and pain intensity. The trial is registered in ClinicalTrials.gov as a pilot feasibility study ahead of a potential full-scale RCT.

Abdominal and Lower Extremity Adipose Tissue Elasticity in Patients With Lipedema

NIH has registered a new observational clinical trial (NCT07536646) investigating abdominal and lower extremity adipose tissue elasticity in patients with lipedema using shear wave elastography (SWE). The study will compare subcutaneous tissue stiffness between lipedema patients and healthy controls, and evaluate differences between abdominal and lower extremity measurements within the same patients. Lipedema is a chronic disorder predominantly affecting women and is often underrecognized or confused with obesity, venous insufficiency, and lymphedema.

Cancer Exercise App Trial for Post-Treatment Survivors

NIH registered a randomized controlled clinical trial (NCT07535918) evaluating the Cancer Exercise app (CEA) designed to promote physical activity among cancer survivors who have completed treatment. The 12-week home-based exercise program will randomize 240 participants into CEA or usual care groups to measure intervention effects on physical activity levels. The trial is registered with anticipated completion in April 2026.

REPRESENT-PF Registry, Observational, PFA Atrial Fibrillation

NIH ClinicalTrials.gov registered the REPRESENT-PF observational registry (NCT07535268), a pragmatic prospective single-arm multi-center study evaluating FDA-approved Boston Scientific FARAWAVE Pulsed Field Ablation catheters for treatment of atrial fibrillation in underrepresented minority patients. All data collected will be standard of care. Conditions include persistent and paroxysmal atrial fibrillation.

RecoveriX BCI System Clinical Trial for Stroke Gait Rehabilitation

NIH's ClinicalTrials.gov registered a new clinical trial (NCT07537530) evaluating the recoveriX PRO Brain-Computer Interface system for gait rehabilitation in stroke patients. The recoveriX device combines motor imagination with functional electrical stimulation and virtual reality feedback, controlled via EEG signals. The trial will enroll stroke patients and compare BCI-assisted therapy (25 sessions over approximately 8 weeks) against standard FES+VR treatment without EEG monitoring to assess safety and functional improvement in gait ability.

EIT Pilot Study Tests Perfusion and Ventilation Distribution in Children

The NIH has registered a new pilot study (NCT07532811) on ClinicalTrials.gov evaluating the feasibility of assessing pulmonary perfusion in children using electrical impedance tomography (EIT) with a weight-adjusted hypertonic saline bolus. The study addresses a gap in pediatric protocols, as existing adult perfusion assessment methods using 10 mL of 7.5-10% NaCl are unsuitable for small children. The single-center study targets children with acute respiratory failure.

Elecoglipron and Statins PK Study Phase 1 in Healthy Participants

NIH registered a Phase 1 clinical trial (NCT07534592) to investigate pharmacokinetic interactions between elecoglipron and statins (atorvastatin and rosuvastatin) in healthy participants. The single-center study will enroll participants in two groups to assess co-administration effects. Elecoglipron is an investigational drug not yet approved by FDA.

Phase 1 CD19 CAR-γδ T Cells for Relapsed/Refractory Autoimmune Nephropathy

NIH registered a Phase 1 clinical trial (NCT07535138) evaluating CD19 CAR-γδ T cell therapy for patients with relapsed/refractory autoimmune nephropathy, including lupus nephritis, IgA nephropathy, and membranous nephropathy. The single-arm, single-center, open-label dose-escalation study will use a 3+3 design to assess safety, tolerability, recommended dose, and maximum tolerated dose over a 1-year follow-up period.

Effects of 7-Day Creatine Supplementation on Cognitive Function After High-Intensity Interval Training in Active Young Men

NIH ClinicalTrials.gov registered a new clinical trial (NCT07534293) to evaluate whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training in active young men. The randomized controlled trial will enroll 20 participants across four groups receiving placebo or creatine at 0.1 or 0.3 g/KgBW/day, with or without exercise, measuring outcomes via visual reaction time and Trail Making Tests. The trial is listed as Not Yet Recruiting with an anticipated completion date of April 16, 2026.

Novel Hollow Cusp Fracture Reducer Clinical Evaluation

NIH ClinicalTrials.gov registered and published results from a prospective randomized controlled trial (NCT07534904) conducted at Hanzhong Central Hospital between January 2020 and January 2023, evaluating a novel hollow cusp fracture reducer device against conventional manual reduction in 142 patients with femoral shaft and patellar fractures. The device group showed significantly reduced operative time and intraoperative fluoroscopy frequency, improved K-wire placement accuracy, and accelerated fracture healing compared to conventional techniques.

Real-Time MAP Forecasts, Cesarean Delivery Pilot Study

NIH's ClinicalTrials.gov registered a single-center, open-label pilot study (NCT07534774) evaluating a real-time maternal mean arterial pressure (MAP) decision-support algorithm during elective cesarean delivery under spinal anesthesia. The clinician-facing display provides 1-, 2-, and 3-minute MAP forecasts from spinal anesthesia administration until delivery or up to 20 minutes. Clinicians retain full autonomy over treatment decisions with no dosing recommendations provided. Primary outcome is prospective accuracy of short-horizon MAP forecasts; secondary outcomes assess intraoperative hypotension burden and phenylephrine exposure.

Chemogenetic Gene Therapy for Parkinson's Disease Using AAV Virus and Stereotactic Surgery

NIH registered a Phase 1 clinical trial (NCT07533591) evaluating a chemogenetic gene therapy called STP-001 for Parkinson's disease. The therapy uses an AAV viral vector with hM4Di chemogenetic effector delivered via stereotactic surgery to the subthalamic nucleus, combined with clozapine to modulate neuronal activity. The study aims to improve core motor symptoms in PD patients.

Impact of Atypical Swallowing on Periodontal Health in Adults

The NIH ClinicalTrials.gov registry has posted NCT07534306, an observational study examining the prevalence of atypical (dysfunctional) swallowing in adults with periodontitis. The study will investigate correlations between abnormal tongue thrust patterns and clinical oral manifestations including dental mobility and periodontal deterioration. Researchers will collect data through patient questionnaires and clinical evaluations to assess how incorrect lingual posture affects tooth-supporting tissues.

Orthodontic and Articular Effects of the One-Step No-Prep Protocol

NIH's ClinicalTrials.gov registered a new observational study (NCT07533240) investigating the One-Step No-Prep protocol for treating localized tooth wear in adults. The study will evaluate orthodontic tooth movements, temporomandibular joint function, and restoration stability using digital scans, 3D imaging, and jaw-tracking. Participants will receive bonded restorations combined with orthodontic mechanics and complete questionnaires on comfort and satisfaction.

Phase 1 Pomalidomide After CAR T-Cell Therapy for Relapsed or Refractory CD19+ B-Cell Leukemia or Lymphoma

The NIH National Library of Medicine registered Phase 1 clinical trial NCT07532525 to evaluate pomalidomide following CD19 CAR T-cell therapy for relapsed or refractory CD19+ B-cell leukemia or lymphoma. The single-arm trial will assess safety and preliminary effectiveness of the combination therapy in approximately 24 participants.

Observational Study Comparing Leadless Pacemakers and Left Bundle Branch Area Pacing

NIH registered clinical trial NCT07534917, an observational acute study comparing leadless right ventricular pacemakers and temporary left bundle branch area pacing on cardiac function and tricuspid valve. Both procedures conducted in one sitting under general anesthesia. Participants referred for routine pacemaker implantation may enroll. The study aims to guide pacemaker type selection for patients at risk of valve or heart dysfunction.

PancreasPlus App Monitors Pancreatic Cancer Patients

NIH ClinicalTrials.gov registered study NCT07532590 evaluating the PancreasPlus mobile app for pancreatic cancer patients. The single-arm feasibility study will assess patient engagement, questionnaire completion rates, perceived service quality, and anxiety reduction through use of the app for remote symptom monitoring and caregiver support. The study anticipates enrolling patients over an undefined period with a primary completion date of April 16, 2026.

OMT vs Exercise in TMD Clinical Trial

NIH ClinicalTrials.gov registered a randomized clinical trial (NCT07534540) comparing osteopathic manipulative treatment (OMT) versus a structured home-based exercise program in adults diagnosed with myogenic temporomandibular disorders (TMD). The trial will assess pain intensity, functional outcomes, postural stability, and quality of life across intervention groups. Enrollment status and specific trial sites are not detailed in the registry record.

Characterization of Pulp Inflammation: Observational Study Using Biological Samples

NIH registered ClinicalTrials.gov study NCT07533396, an observational investigation of pulpal inflammation using biological samples collected during routine dental care. The study aims to validate a new diagnostic classification (Endolight) for guiding vital pulp therapy indications and to identify molecular and protein biomarkers associated with inflammatory severity. The trial enrolls patients undergoing routine dental procedures and requires collection of biological samples for analysis.

Effects of Instrument-Assisted Constant-Speed Injection Versus Manual Injection on Pain From Large-Volume Subcutaneous Injection of Pertuzumab and Trastuzumab in Breast Cancer: A Randomized, Self-Controlled Study

NIH registered a clinical trial (NCT07533526) on ClinicalTrials.gov comparing instrument-assisted constant-speed injection versus manual injection for subcutaneous administration of pertuzumab and trastuzumab in breast cancer patients. The randomized, self-controlled study plans to enroll 40 female patients, with each receiving both injection methods across two treatment cycles. Pain intensity will be measured using the Numerical Rating Scale immediately after injection.

Rescue Treatment of Helicobacter Pylori Based on Fecal Antimicrobial Resistance Gene Testing

NIH's ClinicalTrials.gov has registered a new Phase 4 clinical trial (NCT07533422) evaluating fecal-based antimicrobial resistance gene testing to guide personalized Helicobacter pylori rescue therapy. The study will enroll patients who have failed initial treatment and compare personalized treatment based on fecal resistance profiles against conventional quadruple therapy, measuring eradication rates and safety outcomes.

Animal-Shaped Magic Mirrors Reduce Child Vaccination Pain

NIH registered observational study NCT07535151 on April 16, 2026, examining the effect of animal-shaped magic mirrors on pain in children aged 1-4 years during vaccination and maternal anxiety. The single-center study aims to evaluate non-pharmacological interventions for reducing procedural pain in pediatric populations. Results may inform clinical practices for managing vaccination-related distress in young children.

Post-Debonding Finishing in Orthodontics - Observational Study NCT07534423

NIH registered observational study NCT07534423 investigating clinical approaches to orthodontic debonding and post-debonding finishing, focusing on enamel preservation. The study conducted an observational epidemiological survey among dental professionals to assess techniques, instruments, and complications. Results highlight variability in clinical protocols, with mechanical methods being most widely adopted, and emphasize minimally invasive strategies to reduce enamel damage and improve patient outcomes.

GT307 TIL Injection Clinical Trial for Metastatic Solid Tumors

NIH ClinicalTrials.gov registered a new single-center, single-arm, open-label clinical study (NCT07534813) evaluating GT307, an autologous tumor-infiltrating lymphocyte (TIL) injection, in patients with advanced solid tumors. The Phase I/II trial will assess safety, tolerability, pharmacokinetics, efficacy, and optimal dosing. The study is registered with an anticipated start date of April 16, 2026.

Impact of Eating Disorders Study

NIH registered observational clinical trial NCT07534059 titled 'Impact of Eating Disorders Study' on ClinicalTrials.gov. The study examines eating disorders including anorexia nervosa and bulimia nervosa in adolescent populations, with estimated prevalence data for anorexia nervosa at 2-3% among young adults and a 5-10% 10-year mortality rate. This is a registry entry providing study information and does not create compliance obligations.

Brepocitinib Phase 2/3 Trial for Lichen Planopilaris in Adults

NIH ClinicalTrials.gov registered a Phase 2/3 study (NCT07532603) evaluating oral brepocitinib versus placebo in adults with lichen planopilaris. The trial will assess clinical safety and efficacy of the investigational drug. Registration posted April 16.

JSKN016 Phase III Trial for Triple-Negative Breast Cancer

NIH registered a Phase III clinical trial (NCT07533123) evaluating JSKN016 versus Treatment of Physician's Choice in patients with unresectable locally advanced, recurrent, or metastatic triple-negative breast cancer (TNBC) who have failed standard of care. The randomized trial will assess progression-free survival and overall survival as primary endpoints. Investigational interventions include JSKN016 Injection and multiple comparator chemotherapies including eribulin, vinorelbine, capecitabine, gemcitabine, and sacituzumab govitecan.