ClinicalTrials.gov Studies

Turkish Version of the Eksterociptive Body Awareness Questionnaire Validation Study NCT07536685

The National Institutes of Health registered an observational study (NCT07536685) to validate the Turkish version of the Eksterociptive Body Awareness Questionnaire (EBA-Q). The study involves 70 healthy adult participants who will complete a survey using the questionnaire. The study aims to establish the validity and reliability of the instrument for use in Turkish research.

Measurement of Ocular Blood Flow and Retinal Oxygen Extraction in Diabetic Patients

NIH has registered a clinical trial (NCT07536516) investigating the impact of GLP-1 receptor agonists (semaglutide, liraglutide) and GIP/GLP-1 dual agonists (tirzepatide) on ocular blood flow and retinal function in diabetic patients. The study will use Laser Speckle Flowgraphy (LSFG), Optical Coherence Tomography (OCT), and Optical Coherence Tomography Angiography (OCT-A) as diagnostic interventions. The trial focuses on patients with diabetes mellitus to evaluate potential neuroprotective effects on retinal microvasculature.

AI-ECG Observational Study for Acute Aortic Dissection

NIH registered a prospective multicenter observational study (NCT07536932) evaluating an AI-ECG model for diagnosing acute type A aortic dissection in emergency department patients with chest pain. The study will enroll adults at five tertiary hospitals and compare AI model predictions against CTA-confirmed diagnoses. Clinical and ECG data will be collected as part of standard care to assess diagnostic performance across centers.

Telerehabilitation vs Conventional Rehab Non-Inferiority Trial for Subacromial Pain

NIH has registered a clinical trial (NCT07536009) on ClinicalTrials.gov evaluating whether a telerehabilitation program is non-inferior to conventional in-person physical therapy for patients with subacromial pain syndrome. The prospective, randomized, parallel-group, single-center controlled non-inferiority trial will measure primary outcome of shoulder function using the QuickDASH questionnaire at 12 weeks. Secondary outcomes include pain intensity, range of motion, treatment adherence, and long-term functional outcomes.

ALN-4915 Phase 1 Trial, Healthy Volunteers

Alnylam has registered a Phase 1 clinical trial for ALN-4915 on ClinicalTrials.gov (NCT07535606). The study will evaluate safety, tolerability, pharmacodynamics, and pharmacokinetics of ALN-4915 in adult healthy volunteers. The trial involves approximately 60 participants receiving ALN-4915 or placebo.

Open Label SKY-0515 Huntington's Disease Trial Phase 2

NIH ClinicalTrials.gov registered a Phase 2 open-label extension study (NCT07537075) for SKY-0515, an oral medication being evaluated for Huntington's Disease. The trial will enroll adults aged 25 and older with genetically confirmed HD to assess whether SKY-0515 can lower harmful proteins associated with the disease and improve symptoms. The study is registered as Phase 2 with an anticipated start date.

Observational BMPR2-Activin Pathway Study in Group II Pulmonary Hypertension

The NIH registered a prospective observational study (NCT07537517) on ClinicalTrials.gov evaluating the BMPR2-activin signaling pathway in Group II pulmonary hypertension associated with left heart disease. The study will enroll 150 heart failure patients undergoing hemodynamic assessment with a 1-year follow-up, plus a nested substudy of 40 heart transplant candidates for vascular morphometric analysis. Results may inform PH-LHD classification, precision-medicine models, and targeted therapies such as activin inhibitors.

ESPB vs ICNB Postoperative Pain VATS Randomized Trial

NIH's ClinicalTrials.gov has registered study NCT07535697, a prospective randomized trial comparing ultrasound-guided erector spinae plane block (ESPB) to thoracoscopically-guided intercostal nerve block (ICNB) for postoperative pain management in adults undergoing video-assisted thoracoscopic surgery (VATS). The study will evaluate analgesic consumption over 24 hours, pain levels at predefined time points, and procedure duration to determine whether ESPB provides comparable analgesia to ICNB.

KIA-Korekt: Staged Unimodal-to-Multimodal AI Evaluation for Perioperative Risk Prediction in Colorectal Cancer

NIH ClinicalTrials.gov registered NCT07537491 (KIA-Korekt study), an observational study conducted at University Hospital Brandenburg investigating whether multimodal AI analysis of medical imaging can predict perioperative complications in colorectal cancer patients. The study integrates digital histopathology (H&E-WSIs), CT/MRI radiomics, and multiplex tissue imaging across a retrospective cohort of approximately 750 CRC patients (2011–2021) and a prospective validation cohort of approximately 210 patients (2026–2028).

Phase 2 CAOP Trial for Peripheral T-Cell Lymphoma

NIH registered a Phase 2 clinical trial (NCT07535762) evaluating CAOP (Aclarubicin, Cyclophosphamide, Vincristine, Prednisone) in elderly patients with newly diagnosed Peripheral T-Cell Lymphoma (PTCL). The trial targets three subtypes: PTCL-NOS, Nodal T-follicular Helper Cell Lymphoma, and ALK-1 Negative Anaplastic Large Cell Lymphoma. The study aims to address poor survival rates with current CHOP-based therapies in this rare cancer population.

Predictors of Clinical Response After Interlaminar Cervical Epidural Steroid Injection for Cervical Radiculopathy

NIH registered a new observational retrospective cohort study (NCT07535476) on ClinicalTrials.gov to evaluate predictors of clinical response after interlaminar cervical epidural steroid injection in patients with cervical radiculopathy. The study will analyze demographic, clinical, and procedure-related variables including pain scores before and after the procedure. Enrollment is anticipated to begin April 17, 2026.

Observational Trial NCT07537153 - Unapproved Device

NIH registered observational clinical trial NCT07537153 on ClinicalTrials.gov. The trial involves a device that has not been approved or cleared by the U.S. FDA for its intended use. Registration satisfies FDA requirements for ongoing clinical investigations of unapproved devices. Trial status listed as active with data collection ongoing.

Oxidative Stress in Autoimmune Rheumatic Diseases

NIH National Library of Medicine registered an observational study (NCT07536529) examining oxidative stress markers in autoimmune rheumatic diseases including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. The study measures blood and tissue redox status to understand free radical impact on biomolecules in inflammatory joint disease patients. This registry entry applies to clinical investigators and healthcare providers involved in the study.

Clinical Decision-Making in FAIS

NIH registered clinical trial NCT07536295 studying dynamic assessment methods for femoroacetabular impingement syndrome (FAIS) surgery decisions. The study aims to develop and validate clinic-ready dynamic assessment methods integrating weight-bearing pelvic alignment with 3D hip modeling to support more objective treatment timing.

Efficacy of Cosmetic Products in Preventing HEVL-Induced Skin Pigmentation

NIH registered a double-blind, randomized clinical trial (NCT07537595) evaluating the efficacy of seven anti-pigmentation cosmetic formulations in preventing skin pigmentation induced by High Energy Visible Light (HEVL, 400-450nm) in 18-60 year old Caucasian healthy volunteers. Participants will undergo 36 visits over 7 weeks with standardized product applications on delineated skin zones followed by HEVL exposure and colorimetric measurements at 13 time points.

Group Music Therapy Pilot, Emotional Health, Long-Term Care

This is a ClinicalTrials.gov registration for a pilot study (NCT07536360) evaluating group music therapy's effects on emotional health among long-term care residents. The study will also assess the feasibility of using AI-based facial emotion recognition technology (PaLI Gemma 2 multimodal model) alongside traditional self-reported emotional health questionnaires. Participants will attend six 60-minute weekly sessions with pre/post assessments.

Correlation Between Smartphone Addiction, Sleep Problems and Body Mass Index in School Age Children

NIH registered an observational study (NCT07536334) on ClinicalTrials.gov examining the relationship between smartphone addiction, sleep problems, and BMI in school-age children. The study is an observational cohort with no interventions. Conditions include obesity, overweight, and sleep disorders. No compliance obligations are created by this study registration.

Impact of PDT and Topical Corticosteroids on Taste Perception in Patients With OLP

NIH ClinicalTrials.gov registered a new comparative effectiveness study (NCT07536737) evaluating photodynamic therapy versus topical corticosteroids for treating oral lichen planus and their effects on taste perception. The randomized controlled trial will enroll patients receiving either 5-Amino Levulinic Acid-based PDT or Clobetasol Propionate 0.05% Cream, assessing taste recognition and lesion outcomes. Study findings may inform clinical treatment selection for OLP patients experiencing taste disturbances.

EBV Reactivation Longitudinal Cohort Study, 100 Adults, 18-29, Australia

NIH registered observational cohort study NCT07536048 on ClinicalTrials.gov tracking EBV reactivation in 100 EBV seropositive adults aged 18-29 years in Australia. The prospective longitudinal study will follow participants over 6-12 months with no study interventions. Participants will undergo immunological and clinical data collection at designated study centers.

Predictors & Mechanisms of Adolescent PTSD - Early Phase 1 Clinical Trial NCT07537764

The NIH registered Early Phase 1 clinical trial NCT07537764 on ClinicalTrials.gov to study biobehavioral predictors and mechanisms of PTSD response in trauma-exposed adolescents. The study will assess brain activity, physiological responses, and behavior during experimental tasks involving threat reactivity, emotion regulation, and script-driven imagery. Findings may inform future exposure-based intervention development for adolescent PTSD.

Aloe Vera-Peppermint Gel Pressure Injury Prevention ICU Randomized Controlled Trial

NIH ClinicalTrials.gov registered a randomized controlled trial (NCT07537101) evaluating whether combined Aloe Vera-Peppermint gel application reduces pressure injury incidence compared to standard hospital nursing care among ICU patients. Participants will be randomly assigned to receive either the gel intervention or standard care. The trial targets adult ICU patients at risk for pressure injuries (bedsores).

Nurse-Led Nutrition and Exercise Program for Hemodialysis Patients

NIH registered a randomized controlled trial (NCT07535957) evaluating a nurse-led integrated nutrition and exercise intervention for hemodialysis patients. The study will compare structured nutritional counseling and supervised exercise against usual care, measuring quality of life improvements over a follow-up period.

Inulin-Spirulina Co-intervention for Insomnia Disorder

NIH National Library of Medicine registered a clinical trial (NCT07537192) on ClinicalTrials.gov investigating inulin and spirulina dietary supplements as co-interventions for insomnia disorder in adults aged 18 to 60 years. The 12-week randomized controlled trial will enroll participants in four arms (inulin, spirulina, combined, placebo) and measure sleep quality, mood, anxiety, and cognitive outcomes. Researchers will monitor adverse events and collect polysomnography and biospecimen data at baseline and week 12.

Intradermal Acupuncture Ocular Surface Facial Paralysis

The NIH has registered a clinical trial (NCT07537426) examining the efficacy of intradermal acupuncture for treating ocular surface diseases following intractable facial paralysis. The randomized controlled trial will compare active acupuncture intervention against sham-needle placebo, with the primary endpoint measured by Ocular Surface Disease Index score reduction.

Xeomin and Tadalafil Phase 2 ED Trial

NIH registered a Phase 2 clinical trial (NCT07537855) evaluating intracavernosal incobotulinumtoxinA (Xeomin, 100 Units) combined with tadalafil for treating mild-moderate erectile dysfunction in approximately 30 million affected men. The randomized crossover pilot study enrolls male participants to assess efficacy where PDE5 inhibitors alone may be insufficient. ClinicalTrials.gov study record posted April 17, 2026.

Phase 1 Aclarubicin CAOP Trial for Cutaneous T-Cell Lymphoma

NIH registered Phase 1 trial NCT07535710 on ClinicalTrials.gov evaluating Aclarubicin combined with Cyclophosphamide, Vincristine, and Prednisone (CAOP) in patients with previously treated Cutaneous T-cell Lymphoma. The study aims to determine maximum tolerated dose, safety, and efficacy of the regimen. Aclarubicin is an anthracycline antibiotic notable for lacking cardiotoxicity compared to traditional anthracyclines like doxorubicin.

Testing Non-Nutrition Menu Labels on Food Selections

NIH registered clinical trial NCT07536126 testing the effects of environmental harm menu label designs on the healthfulness of fast-food meal choices. The randomized study will have participants complete hypothetical online meal ordering tasks across five labeling conditions to assess impacts on healthfulness, nutrient content, and price. Secondary outcomes include label noticeability and consumer perceptions across conditions.

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

The NIH registered ClinicalTrials.gov study NCT07536204, an observational study examining JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with periodontitis. The study aims to determine whether the JAK1/2 pathway is overactivated in periodontitis compared to health. Participants will donate gingival tissue for analysis.

Effectiveness of Autobrush® Versus Manual Toothbrush Among Adolescents With Fixed Orthodontic Appliances

NIH ClinicalTrials.gov registered a randomized crossover clinical trial (NCT07537790) comparing the effectiveness of Autobrush® U-shaped automatic toothbrush versus conventional manual toothbrush in reducing dental plaque among adolescents aged 12-15 with fixed orthodontic appliances. The study will measure Full Mouth Plaque Score (FMPS) as the primary outcome and is being conducted at KAUD in Saudi Arabia.

Observational Study: Respiration Measured Via End-Tidal CO2 and Spirometry

NIH's ClinicalTrials.gov registered an observational study (NCT07537478) titled RESPI to collect respiration data via end-tidal CO2 and spirometry and compare the two measurement methods. The study focuses on respiration rate detection conditions using wearable respiration masks as interventions. This is a registry entry for an observational clinical study with no immediate compliance obligations.

Vonoprazan vs Esomeprazole H. pylori Eradication Phase 4 Study

NIH registered a Phase 4 clinical trial (NCT07537634) comparing vonoprazan-based levofloxacin-containing triple therapy versus esomeprazole-based levofloxacin-containing triple therapy for Helicobacter pylori eradication in adults with dyspepsia. The randomized open-label study will randomly assign participants to 14-day treatment regimens with follow-up stool antigen testing at 4 weeks post-therapy to assess eradication efficacy and adverse effects.

Phase I Study: Itraconazole Effect on Pharmacokinetics of HS-10506

The NIH ClinicalTrials.gov registry has registered Phase I clinical trial NCT07535970, a single-center, open-label, fixed-sequence, self-controlled study evaluating the effect of itraconazole (a CYP3A inhibitor) on the pharmacokinetics of HS-10506 tablets in healthy Chinese adult participants. The trial is categorized as Phase 1 and is expected to begin on April 17, 2026.

SEHAT Virtual Oral Health Promotion for School Adolescents in Pakistan

NIH registered clinical trial NCT07536958 on ClinicalTrials.gov, a cluster-randomized trial evaluating the SEHAT virtual oral health promotion program among school adolescents in Pakistan. The trial will compare virtual SEHAT sessions delivered via Zoom against conventional in-person oral health education and a control group, assessing outcomes including toothbrushing behavior, plaque scores, gingival scores, and oral health knowledge.

Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis

NIH registered a new clinical trial on ClinicalTrials.gov (NCT07537114) to study the effects of rhythmic auditory stimulation—walking with music versus walking with a metronome versus walking without sound—on pain and muscle activation in individuals with chronic knee osteoarthritis. The trial will enroll participants receiving one of three interventions: rhythmic auditory stimulation with music, rhythmic auditory stimulation with a metronome, or a control group with no auditory cueing.

Clinical Trial Evaluating Moxibustion for Cold-Syndrome Allergic Rhinitis

NIH's ClinicalTrials.gov has registered a new interventional study (NCT07537439) evaluating the adjunctive effects of mild moxibustion combined with fluticasone propionate (100 mcg) for treating cold-syndrome allergic rhinitis. The randomized trial will assess outcomes including symptom relief, quality of life, and work productivity in patients with IgE-mediated allergic rhinitis. Estimated study completion date is April 17, 2026.

Benmelstobart Plus Anlotinib Combined With SBRT for Hepatocellular Carcinoma

NIH ClinicalTrials.gov registered Phase 2 trial NCT07537777 evaluating Benmelstobart plus anlotinib combined with stereotactic body radiation therapy (SBRT) in patients with oligometastatic hepatocellular carcinoma who have failed first-line targeted therapy. The prospective, single-arm, multicenter study will assess progression-free survival, objective response rate, disease control rate, overall survival, and treatment safety. Eligible patients receive anlotinib 10mg on days 1-14 every 3 weeks plus Benmelstobart 1200mg on day 1 every 3 weeks combined with SBRT.

Surgery Plus Systemic Therapy for Liver Cancer With Extrahepatic Metastases

NIH ClinicalTrials.gov has registered NCT07537959, a randomized trial evaluating whether adding primary tumor resection to standard immune-based systemic therapy improves survival in hepatocellular carcinoma patients with extrahepatic metastases. The study will enroll approximately 252 participants and measure overall survival as the primary endpoint.

EENC Clinical Trial: 162 Mother-Baby Pairs, Shaikh Zayed Hospital, Pakistan

NIH ClinicalTrials.gov registered study NCT07535684 examining Early Essential Newborn Care (EENC) versus routine postnatal care. The single-center trial enrolled 162 mother-baby pairs at Shaikh Zayed Hospital, Rahim Yar Khan, Pakistan. EENC interventions include immediate drying, skin-to-skin contact, delayed cord clamping, thermal care, and breastfeeding initiation within one hour. The study assesses newborn outcomes including early breastfeeding, exclusive breastfeeding at 7 days, hypothermia, hypoglycemia, NICU admission, and maternal outcomes.

Sintilimab Plus Lenvatinib Phase 3 Trial for Oligo-Extrahepatic Metastatic Hepatocellular Carcinoma

The NIH ClinicalTrials.gov registry published a Phase 3 study (NCT07537946) evaluating sintilimab plus lenvatinib with or without consolidative therapy in patients with oligo-extrahepatic metastatic hepatocellular carcinoma. The randomized 1:1 trial enrolls participants who achieved disease control after 4 induction cycles. The primary endpoint is overall survival.

GEN-AL-RF Trial: Genicular Nerve RF Ablation vs Alcohol Neurolysis for Knee Osteoarthritis Pain

The NIH ClinicalTrials.gov registry has published NCT07537335, a randomized controlled trial comparing genicular nerve radiofrequency ablation to neurolytic alcohol injection for managing chronic knee pain in osteoarthritis patients. The 6-month study will assess pain intensity using the Numeric Rating Scale, physical function via WOMAC scores, and quality of life through SF-12 metrics. Results aim to provide comparative effectiveness evidence for these interventional pain management techniques.

Baricitinib Phase 1b/2 Trial for Post-HSCT Persistent Thrombocytopenia

NIH registered a Phase 1b/2 clinical trial (NCT07535645) on ClinicalTrials.gov studying baricitinib in patients with thrombopoietin-receptor-agonist-refractory persistent thrombocytopenia following allogeneic hematopoietic stem cell transplantation. The prospective, open-label trial will evaluate safety and efficacy profiles of the JAK inhibitor intervention.

VENEZE Peptide Hair Serum vs 2% Minoxidil for Androgenetic Alopecia

NIH registered a randomized, double-blind Phase 4 clinical trial (NCT07536100) comparing VENEZE peptide hair serum to topical 2% minoxidil in approximately 300 patients with androgenetic alopecia. Participants will be assessed for changes in hair density, hair thickness, and treatment tolerability over the study period. The trial aims to evaluate whether a peptide-based serum offers a viable alternative to standard minoxidil therapy.

Effect of Myopia-Control Contact Lenses in New Zealand Chinese Children

NIH registered Phase 3 clinical trial NCT07535749 evaluating myopia progression control using MiSight 1 Day (CooperVision) and Abiliti 1-Day (Johnson & Johnson VisionCare) contact lenses in New Zealand Chinese children. The 6-month randomized controlled paired-eye study will enroll participants at Auckland Myopia Clinic with assessments at baseline, 2 weeks, 3 months, and 6 months.

Expanded Access Program for Leronlimab in Metastatic TNBC

NIH's ClinicalTrials.gov registered an Expanded Access Program for investigational leronlimab (PRO 140) in metastatic triple-negative breast cancer, offering a pathway for patients lacking satisfactory treatment options and unable to enroll in clinical trials. The observational, open-label study documents program eligibility, interventions, and study design. No new compliance obligations are created for sponsors, healthcare providers, or patients.

Prospective Exploration of Vascular Complications Associated With Immune Checkpoint Inhibitors

NIH registered an observational study (NCT07535944) on ClinicalTrials.gov to explore vascular complications associated with immune checkpoint inhibitors (ICIs). The study will evaluate the vascular impact of ICIs such as nivolumab, pembrolizumab, and atezolizumab in cancer patients. ICIs have been linked to immune-mediated toxicities affecting various organ systems, including the cardiovascular system, though vascular complications remain poorly understood.

Intra-Arterial Tirofiban After Complete Recanalization for Acute Intracranial Large-Vessel Occlusion

NIH registered a Phase 3 clinical trial (NCT07537933) to evaluate whether immediate intra-arterial tirofiban after complete recanalization improves recovery in adults with acute ischemic stroke caused by anterior circulation large-vessel occlusion. The trial will enroll approximately 520 participants and compare tirofiban treatment with no tirofiban, measuring good functional outcome at 90 days and symptomatic intracranial hemorrhage risk. Primary completion is expected April 17, 2026.

Leukemia Stem Cell-based Assay to Predict Relapse and Survival in AML Patients With MLL-Rearrangement

NIH's ClinicalTrials.gov has registered an observational study (NCT07537738) examining whether leukemia stem cell detection via multiparameter flow cytometry can predict relapse in acute myeloid leukemia patients with MLL-rearrangement. The study will detect leukemia stem cells alongside minimal residual disease monitoring using bone marrow samples. Participants are AML patients undergoing regular medical care who will have stem cell detection performed concurrently with their existing MRD testing protocols.

Phase 2 Leucine Diet Trial Combined With Chemoimmunotherapy for Advanced Gastric Cancer

NIH ClinicalTrials.gov registered a Phase 2 study (NCT07537348) evaluating a leucine-restricted diet combined with chemotherapy and immunotherapy in patients with advanced gastric cancer. The trial will assess safety, tolerability, tumor response rates, and 1-year survival outcomes. No compliance obligations or regulatory actions are imposed by this registry entry.

Microbiota in OAB, DUI Children, Healthy Controls Compared

NIH has registered observational study NCT07535619 on ClinicalTrials.gov to investigate whether voided urinary, perineal/preputial, and fecal microbiota differ between children with Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy controls. The study will also assess whether microbiota composition varies by DUI severity and changes throughout treatment.

Effect of Simulation-Based Vaginal Examination Training on Anxiety, Confidence, and Skills in Midwifery Students

NIH's ClinicalTrials.gov registered a randomized controlled quasi-experimental study (NCT07535255) investigating the effects of simulation-based vaginal examination training on skill performance, anxiety, and satisfaction in 67 third-year midwifery students at a state university in Turkey. Results showed simulation training significantly reduced state anxiety in both clinical and laboratory groups (p<0.001) and laboratory group students demonstrated improvements in satisfaction and self-confidence (p<0.05). Clinical group students achieved significantly higher vaginal examination skill scores compared to the laboratory group (p<0.001).