Healthcare Compliance

Novothyrox Prescribing Information From May 2002

FDA received a filing containing historical prescribing information for Novothyrox (a thyroid medication) originally dated May 2002. The document is available as a PDF attachment via regulations.gov. No new regulatory requirements, compliance obligations, or enforcement actions are described.

Zyloprim Approval Package Background Material

FDA published the background material for the Zyloprim (allopurinol) approval package. Zyloprim is a xanthine oxidase inhibitor used to treat gout and conditions involving elevated uric acid. The document is available for download from Regulations.gov as FDA-2026-P-4112-0070.

Orange Book 46th Edition

The FDA has published the 46th edition of the Orange Book (Approved Drug Products with Therapeutic Equivalence Evaluations). The Orange Book is the authoritative FDA reference listing approved prescription drug products, including patent and exclusivity information used by generic drug manufacturers, pharmacy benefit managers, and healthcare payers to assess therapeutic equivalence.

FDA Crystallography Toolbox, Small Molecule Structure Determination

The FDA published a Crystallography Toolbox document on Regulations.gov to support small molecule structure determination in pharmaceutical research and development. The document, filed as FDA-2026-P-4112-0049, provides technical resources for analytical chemistry applications. Access to the full content is restricted due to copyright limitations.

Kuballa NMR Spectroscopy Transitions to Multi-Analysis Method

FDA filed a response to a petition from Kuballa regarding NMR spectroscopy methodology transitioning to a multi-analysis method. The document, filed under docket FDA-2026-P-4112, is available as a downloadable PDF attachment. No compliance obligations, deadlines, or penalties are stated in the available source content.

GE 2024 Financial Exhibit, FDA Regulatory Document, Restricted

A financial exhibit for 2024 filed by GE with the FDA, catalogued on regulations.gov under docket FDA-2026-P-4112-0081. The substantive content of the exhibit is not publicly available as it is restricted due to copyright.

FDA Closes Complaint on Potential Regulatory Violation

FDA's Center for Tobacco Products filed complaint FDA-2026-H-4016 alleging a potential regulatory violation. The complaint was closed on April 21, 2026, with no further visible action taken. The document listing on regulations.gov contains no downloadable attachments or enforcement details.

USAN Council Adopts TAM Nonproprietary Name

The USAN Council, operating in cooperation with the FDA, has adopted the nonproprietary name 'TAM' for a substance. The adopted name has been filed with the FDA as a public notice. This naming action establishes the official United States Adopted Name for the substance, which will serve as its standard nonproprietary designation in pharmaceutical and medical contexts.

USAN Council Issues Statement on Aliskiren Fumarate Naming

The United States Adopted Names (USAN) Council issued a statement assigning the official non-proprietary name 'aliskiren fumarate' for the drug compound. This designation provides the standardized USAN name that pharmaceutical manufacturers must use in labeling, applications, and communications. The statement was filed with the FDA as document FDA-2026-P-4112.

HRSA Health Center Program Forms OMB Review

HRSA has submitted an information collection request to OMB for revised Health Center Program forms under OMB No. 0915-0285. The notice requests public comment on the paperwork burden and substance of the revised forms. The comment period closes 30 days from the April 22, 2026 publication date.

Two Confirmed Measles Cases Identified in Virginia Northwest Region

The Virginia Department of Health confirmed two measles cases in the Northwest Region on April 21, 2026 — a preschool-age child (0–4 years) and a school-age child (5–12 years) who traveled together domestically. Exposure sites include KidMed Stafford Urgent Care (April 16, 4:30–8 p.m.) and Grafton Village Elementary School in Fredericksburg (April 9–10, April 13–16, and April 20). Virginia has recorded 19 measles cases in 2026 to date. Exposed individuals are advised to report via VDH survey, verify MMR vaccination status, monitor for symptoms for 21 days, and contact healthcare providers if not fully vaccinated or symptomatic.

National Registry Radiation Workers UK GDPR Privacy Notice

UKHSA published its privacy notice for the National Registry for Radiation Workers (NRRW), explaining how personal data is collected, processed, and protected under UK GDPR. The registry covers radiation workers employed by participating organisations since 1976, with retrospective data going back to the late 1940s, collecting identifying information, employment details, and radiation exposure data. Individual personal data is not shared outside UKHSA, though aggregated data may be shared with international collaborating scientists for combined cohort analyses.

Pilot Study Evaluates Occupational Health Data for Radiation Effects

UKHSA has announced a pilot study to evaluate approximately 7,000 electronically stored occupational health records from Springfields Fuels Ltd, assessing data on smoking, alcohol consumption, blood pressure, obesity, and asbestos exposure. The study will match this health and lifestyle information to workers in the National Registry of Radiation Workers (NRRW) to determine if such data can improve the accuracy of radiation risk estimates for common diseases. Upon completion, the dataset will be deleted while extraction and matching programs are retained for potential future use.

NRRW Radiation Worker Cohort: Non-Melanoma Skin Cancer and Ischaemic Heart Disease Dose-Response Studies

UKHSA published results from two studies based on the National Registry for Radiation Workers (NRRW) cohort examining radiation dose-response relationships for non-melanoma skin cancer (NMSC) and ischaemic heart disease (IHD) mortality. The NMSC study (172,452 workers, 5.25 million person-years) found that basal cell carcinoma (BCC) risk increased with cumulative radiation dose but the association was largely explained by ultraviolet radiation exposure based on tumour location. The IHD study (174,541 workers, 9,814 deaths) found a statistically significant excess relative risk of 0.32 per sievert, with a linear-quadratic dose-response relationship exhibiting downward curvature at doses above 0.4 Sv. Both studies were published in peer-reviewed journals (International Journal of Cancer and Journal of Radiological Protection) and represent open-access findings from the NRRW third analysis with extended follow-up.

Merger of BNFL, UKAEA and AWE Worker Epidemiology Studies into NRRW

UKHSA has published guidance on the planned merger of three long-term epidemiological studies of nuclear radiation workers into the National Registry for Radiation Workers (NRRW). The three studies—covering workers from British Nuclear Fuels Ltd (BNFL), UK Atomic Energy Authority (UKAEA), and the Atomic Weapons Establishment (AWE)—will be merged on 1 January 2024, creating a single national resource to study radiation risks with increased statistical power. The merger adds approximately 30,000 workers monitored for internal radiation exposure and introduces a non-radiation worker comparison group to account for the healthy worker effect.

National Registry for Radiation Workers Guidance Published by UKHSA

UKHSA published guidance on the National Registry for Radiation Workers (NRRW), a long-running UK epidemiological study established in 1976 to monitor health effects of low-dose occupational radiation exposure. The registry currently holds data on over 270,000 workers from nuclear industry employers including the Ministry of Defence, former British Nuclear Fuels Ltd sites, UK Atomic Energy Authority, and nuclear power generation sites. The study operates an opt-out policy with an estimated opt-out rate of approximately 1%, allowing workers to request exclusion at any time via email.

INWORKS2 Study: Radiation Dose-Response Findings for Nuclear Workers

UKHSA has published findings from the INWORKS2 study, an update to the International Nuclear Workers Study coordinated by the International Agency for Research on Cancer (IARC). The INWORKS2 dataset covers 309,932 nuclear workers across France, the UK, and the US with follow-up from 1944 to 2016, representing a 56% increase in deaths (to 103,553) and an additional 3 million person-years of observation compared to the original INWORKS dataset. The study examines dose-response relationships between cumulative external radiation exposure and mortality from solid cancers, haematological cancers, and non-cancer outcomes.

INWORKS: Collaborative Study on Nuclear Workers Using NRRW Data

UKHSA published guidance on the International Nuclear Workers Study (INWORKS), an epidemiological study coordinated by IARC that pools data from 308,297 nuclear workers in the UK, US and France. The study found a statistically significant association between radiation dose and mortality from solid cancers (48% increase per Sv), leukaemia (2.96 per Sv), and circulatory diseases (22% per Sv). Mean follow-up was 27 years with 66,632 deaths observed. Mean individual cumulative external dose was 25 mSv over the monitoring period.

No New Measles Cases Since Friday, Outbreak Total Stays 997

South Carolina DPH reported no new measles cases on April 21, 2026, keeping the Upstate outbreak total at 997 cases. Forty-one individuals remain in quarantine related to a Saluda County exposure, with quarantine ending May 9. If no new outbreak-related cases are reported, the outbreak would end April 26, following a 42-day period with no new cases.

Rabid Raccoon Confirmed in Kershaw County; Two Horses Exposed

The South Carolina Department of Public Health confirmed a raccoon found near Bishopville Highway and Lee Road in Camden tested positive for rabies on April 20, 2026, after being submitted for testing on April 17. Two horses were exposed and will be quarantined as required under the South Carolina Rabies Control Act; no human exposures are known at this time. This is the first rabid animal case in Kershaw County in 2026, with 25 cases reported statewide this year and 101 confirmed cases in 2025.

DPH Encourages Residents to Dispose of Unused Prescription Medicines During Drug Take Back Day

SC DPH is encouraging South Carolina residents to participate in the DEA-hosted National Prescription Drug Take Back Day on Saturday, April 25, 2026, from 10 a.m. to 2 p.m., by disposing of unused or expired prescription medications at designated collection sites. The announcement cites state data showing 2,157 drug overdose deaths in 2023 (6.1% decrease from 2022), with 1,840 attributed to prescription drugs, and 1,479 provisional deaths in 2024. Drop-off sites will collect tablets, capsules, patches, and solid prescription drugs; vaping devices, liquids, sharps, and illegal drugs will not be accepted. Free Overdose Prevention Safety Kits containing fentanyl test strips, naloxone (Narcan), and treatment resources are available at DPH health clinics without appointments or ID.

Boil Water Advisory Rescinded for City of Fort Scott Bourbon County

KDHE has rescinded the boil water advisory for the City of Fort Scott public water supply system in Bourbon County, Kansas, effective April 21, 2026. The advisory was originally issued due to a waterline break causing loss of pressure in the distribution system, which risked bacteriological contamination from reduced chlorine residuals. Laboratory testing of drinking water samples collected from the City of Fort Scott showed no evidence of bacteriological contamination, and KDHE officials confirmed all conditions that placed the system at risk are resolved. The advisory remains in effect for Bourbon Co RWD 2C and City of Uniontown public water supply systems.

Boil Water Advisory Rescinded for Jefferson Co RWD 7, Jefferson County

KDHE has rescinded a boil water advisory for Jefferson Co RWD 7 public water supply system in Jefferson County, effective April 21, 2026. The advisory was originally issued on April 16, 2026 due to a waterline break that caused a loss of pressure in the distribution system, which risked chlorine residual loss and bacterial contamination. Laboratory testing of drinking water samples confirmed no bacteriological contamination, and KDHE officials have determined all conditions that placed the system at risk are resolved.

Flexible Instrument Localization from Both Remote and Elongation Sensors

The USPTO granted Patent US12605086B2 to Auris Health, Inc. covering a system and method for tracking flexible elongate instruments within patients. The system combines remote localization measurement data with elongation measurement data, transforming both to a coordinate reference frame to produce more accurate instrument localization than either data source alone. The patent names five inventors: Sean Walker, Dave Camarillo, Matt Roelle, Christopher Sewell, and Aditya Koolwal.

Synchronized Aspiration System with Catheter Sensors for Removal of Acute Blockages from Blood Vessels

USPTO granted Patent US12605499B2 to Neuravi Limited on April 21, 2026, covering a synchronized aspiration catheter system with integrated electrode pairs and pressure sensors for removing acute blood clots from patient vessels. The control console modulates aspiration vacuum pressure based on sensor inputs and optionally the patient's blood pressure waveform. The patent application was filed May 12, 2022, under application number 17743121, with 9 claims.

Method for Determining Respiratory Timing Parameters from Respiratory Monitoring Measurements

The USPTO granted Patent US12605088B2 to Onera Technologies B.V. on April 21, 2026, covering a method for deriving respiratory timing parameters from respiratory monitoring measurements. The patent discloses a computational method involving respiratory effort and flow signal analysis to identify and refine inspiratory onset times using derivative analysis within peak-to-peak intervals. The patent contains 20 claims and names Alessandro Rossi and Hartmut Schneider as inventors.

Impedance Cardiography Device Patent, Tallinn University, Apr 21

The USPTO granted patent US12605084B2 to Tallinn University of Technology on April 21, 2026, covering an impedance cardiography device. The device includes an impedance measuring unit, differentiator, comparator, microcontroller with analog-to-digital converter, and two peak voltage detection units with different polarities. The patent contains 8 claims and was filed on March 27, 2023 under Application No. 18190622.

Photoplethysmogram System Patent, Multiple Light Sources

The USPTO granted Patent US12605077B2 to PranaQ Pte. Ltd. for a photoplethysmogram (PPG) system using multiple light sources of different frequencies (red, infrared, green). The system includes a PPG sensor that detects light after passage through a subject's skin and a processor that estimates physiological parameters including blood oxygen saturation, respiratory effort, pulse rate, and pulse rate variability. The patent contains 12 claims and covers dynamic signal processing methods including calibration using a green light source and imputation of inconsistent PPG signals.

US12605079B2 Physiological Parameter Measurement System, Sonion Nederland

The USPTO granted Patent US12605079B2 to Sonion Nederland B.V. for a system and method measuring physiological parameters of blood-perfused tissue using dual radiation sensors—one sensor measures blood volume via radiation absorption, while the second measures blood flow speed via Doppler shift—with a controller determining the physiological parameter from both data streams. The patent contains 13 claims and covers CPC classifications in the A61B medical diagnosis category.

Physiological Sensor Delivery Device - US12605075B2

USPTO granted patent US12605075B2 to ACIST Medical Systems, Inc. on April 21, 2026, covering an intravascular sensor delivery device and method for measuring physiological parameters such as blood pressure within vascular structures. The device is sized to pass over guidewires for use in coronary and peripheral arteries and can measure pressure gradients across stenotic lesions or heart valves. The patent contains 19 claims with a filing date of April 19, 2021.

Adaptive Pulse Wave Analysis for Blood Pressure Monitoring

The USPTO granted Patent US12605080B2 to Senbiosys on April 21, 2026. The patent covers an adaptive signal processing technique for pulse wave analysis that improves blood pressure estimation by transforming the pulsatility signal to define fiducial points more precisely. The patent application (No. 17455540) was filed on November 18, 2021, and contains 15 claims.

Method and Apparatus for Continuous Vitals Monitoring - US12605078B2

USPTO granted Patent US12605078B2 to Rythmos LLC for a health monitoring device using fiber Bragg grating (FBG) sensors to detect physiological attributes. The device places FBG sensors in contact with skin near arteries or veins to measure refractive index changes and estimates physiological attributes based on strain-induced Bragg wavelength shifts. The patent contains 20 claims.

MRI and Focused Ultrasound Thermal Ablation System

USPTO granted patent US12605071B2 to Shanghai Shende Green Medical Era Healthcare Technology Co., Ltd. for a compatible system enabling synchronized operation of magnetic resonance imaging and focused ultrasound thermal ablation. The system includes a signal collector and control circuit that detects MRI radio frequency signals, records trigger times, and controls focused ultrasound heating duration. The patent contains 8 claims.

Photoacoustic and Ultrasonic Imaging Device, OPTICHO INC

USPTO issued Patent No. US12605072B2 to OPTICHO INC., LTD. for a photoacoustic and ultrasonic imaging device that combines laser light and ultrasonic wave technologies for tissue imaging. The patent covers an imaging probe with a laser emitter and ultrasonic transducer, and an operation unit for image formation from photoacoustic and ultrasonic signals. 19 claims were granted.

Automatic Pupil Detection Method System Google

The USPTO granted patent US12605065B2 to Google LLC for a method and system of detecting pupillary positions on a subject's head. The system uses a camera and light source positioned in front of the subject to capture image data, detect the subject's face, identify up to two eyes, detect the reflection of the light source on each eye, and estimate pupillary position based on the light source reflection. The patent also covers determination of interpupillary distance, left pupil distance, and right pupil distance from the estimated pupillary positions. The patent was filed on July 27, 2020, and contains 19 claims.

US12605064B2 Refractive Pattern Patent Granted

The USPTO granted US Patent 12605064B2 to Shenzhen Thondar Technology Co., Ltd. covering a method and device for generating refractive patterns using fundus imaging of the human eye. The patent includes claims for capturing fundus images, calculating image resolutions, confirming target resolutions, generating a refractive matrix, and producing a refractive pattern. The patent names Ningli Wang, Xuechuan Dong, Yequan Huang, Yan Cui, and Jingyun Guo as inventors.

Verily Health Inc. Patent US12605063B2 — Visual Acuity Measurement in VR Headset

The USPTO granted Patent US12605063B2 to Verily Health Inc. on April 21, 2026. The patent covers a dual-display virtual reality headset with dichroic filter optics configured for automated visual acuity testing, using a smaller secondary display synchronized with pixel-control circuitry to present test patterns. The application was filed March 30, 2023, with 20 claims allowed.

Olympus Winter & Ibe Patent for Albarran and Pull Wire Carrier

The USPTO granted patent US12605052B2 to Olympus Winter & Ibe GmbH for an Albarran and pull wire carrier assembly used in endoscopic instruments. The invention includes a pull wire carrier with a through-bore for a tubular shaft and a receptacle for a releasable cover element, with pull wires fixable between the carrier and cover. The patent contains 12 claims.

OPTOMED PLC Ophthalmic Apparatus Alignment Method

USPTO granted Patent US12605068B2 to OPTOMED PLC for an ophthalmic apparatus with an alignment arrangement that outputs converging alignment light rays forming a predetermined reflection pattern on a target plane. The apparatus includes a communication interface that outputs reflection pattern information from the posterior surface of the eye's crystalline lens to guide or control user positioning by finding the working distance where the predetermined pattern shape appears on the posterior surface.

System health light service app

USPTO granted patent US12605069B2 to Drägerwerk AG & Co. KGaA for a system that transmits health status codes from a first device lacking an alphanumeric display to a second device used by a service technician. The system uses lights and/or sounds from the first device to encode health status information. The second device decodes the series of blinks or sounds to determine the transmitted health status code and may provide repair information or communicate with a remote computer for decoding assistance. The patent contains 19 claims and was filed on June 8, 2023.

Intuitive Surgical Patent: Axial Support Device

USPTO has granted U.S. Patent No. US12605053B2 to Intuitive Surgical Operations, Inc. for flexible elongate devices with axial support structures. The patent covers articulable body portions with transverse support segments and tubular struts for use in surgical applications. The patent contains 23 claims and was filed on June 5, 2024.

Neuroptics Inc. Anisocoria Monitoring Patent US12605066B2 Granted April 21 2026

The USPTO granted patent US12605066B2 to Neuroptics, Inc. on April 21, 2026, covering methods, systems, and devices for monitoring anisocoria and asymmetry of pupillary reaction to stimulus. The patent discloses synchronized recording and display of bilateral pupil response images in response to the same stimulus. The patent contains 3 claims and spans multiple CPC classifications including A61B 3/112, A61B 3/14, and related medical device and healthcare informatics categories.

Optical element movement mechanism for multi-modality ophthalmic imaging systems

USPTO granted US Patent 12605067B2 to Optos plc for an optical element movement mechanism in multi-modality ophthalmic imaging systems. The mechanism rotates optical elements to alternate between imaging modes by moving elements into and out of optical paths. The patent contains 14 claims.

Washington University Cardiac Ablation Patent Granted

The USPTO granted US Patent 12605070B2 to Washington University covering a method for selecting ablation targets for non-invasive cardiac arrhythmia treatment using segmented mapping models. The patent names Clifford Robinson, Phillip Cuculich, and Geoffrey Hugo as inventors and contains 13 claims with filing date May 31, 2022.

AMBU A/S Endoscope Patent for Moulding Transparent Windows

The USPTO granted US Patent 12605045B2 to AMBU A/S for an endoscope and method of moulding transparent windows. The invention covers a two-step polymer moulding process where a first housing part is formed and then a transparent second polymer material is injected via multiple inlets to create a combined housing component. The patent includes 15 claims and was filed on October 28, 2021.

Olympus Medical Sterile Insertion Device

USPTO granted patent US12605048B2 to Olympus Medical Systems Corp. on April 21, 2026. The patent covers a sterilized medical insertion device featuring an insertion portion surrounded by a cover configured to be torn by external force to expose the distal end. The filing date was January 30, 2023, with 16 claims.

EndoVista Steerable Medical Device Control Mechanism

The USPTO granted patent US12605051B2 to EndoVista, Inc. on April 21, 2026, covering a control device for steerable medical devices. The invention includes a steering shaft with first and second steering cams, a latch assembly configurable between inactive and active configurations to control tension in steering wires, and a rotary knob assembly. The patent names five inventors and contains 16 claims under CPC classifications related to surgical and diagnostic devices.

AMBU A/S Injection Moulding Method for Endoscope

USPTO granted US Patent 12,605,046 B2 to AMBU A/S for an injection moulding method used to manufacture an elongate articulated bending section body for an insertion endoscope. The method involves a mould with sub-cavities distributed so each sub-cavity is separated from another by an odd number of sub-cavities without an external fluid inlet. The patent includes 14 claims and names Kaspar Mat Matthison-Hansen as the inventor.

Endoscope Window Attachment via Amorphous Metal Overmoulding to OLYMPUS Winter & Ibe

The USPTO granted Patent US12605047B2 to OLYMPUS Winter & Ibe GmbH covering a method of affixing a window on an endoscope using amorphous metal overmoulding. The patent describes positioning the window in an end part of the endoscope and creating a bezel by overmoulding a lateral edge of the window with amorphous metal. The patent contains 13 claims and covers CPC classifications related to endoscope optics and imaging components.

US12605040B2 Wireless Scanning Device Granted to 3Shape A/S

The USPTO granted Patent US12605040B2 to 3Shape A/S on April 21, 2026. The patent covers a wireless scanning device with an image detector acquiring 2D images at a specified frame rate, processor(s) for forming processed data, and a wireless module for transmitting the processed data. The patent contains 17 claims and has 15 CPC classifications primarily in the A61B (Diagnosis/Surgery) category.