Multiple Antihypertensives Increase Post-Induction Hypotension Risk in Cardiac Surgery
ClinicalTrials.gov Studies
Summary
NIH has registered observational study NCT07541222 investigating whether preoperative use of multiple antihypertensive drug classes increases post-induction hypotension burden in cardiac surgery patients. Researchers will observe whether combinations of ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers correlate with higher incidence and severity of blood pressure drops and increased vasoactive support needs between anesthesia induction and surgical incision.
“The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.”
What changed
NIH has registered a new observational clinical study, NCT07541222, on ClinicalTrials.gov. The study examines whether preoperative use of multiple antihypertensive medication classes increases the burden of post-induction hypotension in patients undergoing elective cardiac surgery.
Clinical investigators and cardiac surgery programs should note this research may inform perioperative medication management protocols. The study focuses on combinations of ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers and their association with blood pressure instability requiring vasoactive support.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients
Observational NCT07541222 Kind: OBSERVATIONAL Apr 21, 2026
Abstract
This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.
Conditions: Hypotension on Induction, Cardiac Surgery, Antihypertensive Agents, Anesthesia, Intravenous, Hemodynamics
Interventions: Chronic Antihypertensive Medication Use
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