ALT-803 IL-15 Soluble Fusion Molecules and Methods

The USPTO published patent application US20260092097A1 for ALT-803, a complex of interleukin-15 (IL-15) superagonist mutant and dimeric IL-15 receptor α/Fc fusion protein. The application covers compositions and methods for enhancing immune response against neoplasia (multiple myeloma, melanoma, lymphoma) or viral infections (HIV). Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han. Application filed June 25, 2025.

Methods of Recellularizing Tissue Transplant for Improved Transplantability

The USPTO published patent application US20260092253A1 for methods of recellularizing an organ or tissue matrix for improved transplantability. Inventors are Doris A. Taylor and Stefan M. Kren. The application was filed December 9, 2025, under application number 19413394. This publication provides public notice of the pending patent application but does not grant any patent rights.

Phase-Changing Matrix for 3D Organoid Culture with Mesenchymal Stem Cells

The USPTO published Application US20260092254A1 claiming a composition for three-dimensional cell and organoid culture comprising a phase-changing matrix with partially ordered polypeptide encapsulating bone-marrow derived or adipose-derived mesenchymal stem cells. The application was filed on September 21, 2023 (Application No. 19113814). This publication provides public notice of the claimed invention for examination purposes.

Cell Based Assays for Botulinum Neurotoxins Serotype-Specific

USPTO published patent application US20260092255A1 for serotype-specific cell-based assays used in characterizing Clostridia botulinum neurotoxins. The assays utilize genetically modified cells capable of discriminating between different serotypes of clostridium neurotoxins without requiring serotype-specific neutralizing antibodies or competing heavy chains. Inventors: Ward Tucker, Francis Mark Dunning, Tim Piazza. Application No. 18920316.

Pepmixes for Multiviral CTL Generation

USPTO published patent application US20260092256A1 by Baylor College of Medicine covering methods of generating CTLs (cytotoxic T lymphocytes) targeting antigens from multiple viruses. The invention uses peptide mixtures exposed to PBMCs with IL4 and IL7 expansion. Published April 2, 2026, Application No. 19020866.

Methods for Generating Hematopoietic Progenitor Cells

The USPTO published patent application US20260092257A1 covering methods for generating human CD34+, CD43+, and CD90+ hematopoietic progenitor cells from hematopoietic stem cells using chemically-defined culture media. The application was filed October 2, 2025, under Application No. 19347888. Inventors include Angelica Gomes Ueltschy and Michael Elias.

Monitoring Assay Performance

The European Patent Office published patent application EP4639562A1 for Genentech, Inc., titled 'Monitoring Assay Performance.' The invention relates to methods and systems for monitoring assay performance and quality control in healthcare diagnostics. The patent was published March 25, 2026, with designated states covering all EPC contracting states.

Vaccine Management System for Preventing Vaccination Accidents

The European Patent Office published patent application EP4641582A1 for Real Time Medi Check Corp's vaccine management system designed to prevent vaccination accidents caused by incorrect vaccination and misregistration. The system covers technology for managing vaccination services and includes claims related to health informatics, tracking, and safety mechanisms.

Decision-making Assistant Tool for Health Informatics

The European Patent Office published patent application EP4634925A1 by Laboratory Corporation of America Holdings (Labcorp) for a decision-making assistant tool in health informatics. The invention is classified under G16H 10/40 and G16H 15/00, with inventors BERBERIAN, Lance, DE VRIES, Enno, LUNK, Jessie, and MOGOLOWITZ, Glenn. The application designates multiple European states including DE, FR, GB, IT, NL, and others.

Closed-Loop Neuromodulation Sleep Patent

The European Patent Office published patent application EP4633707A1 for Elemind Technologies, Inc., covering a closed-loop neuromodulation system for modulating sleep-related oscillations. The invention relates to methods and systems for detecting and responding to sleep states using real-time neural monitoring and adaptive stimulation. International patent classifications include A61M 21/00, A61B 5/00, and G16H 20/00.