USPTO

Assessing Machine Learning Bias Using Model Training Metadata

USPTO granted Patent US12608445B2 to Cisco Technology, Inc. on April 21, 2026. The patent describes a system for assessing bias in machine learning models by comparing input data to training metadata retrieved from a ledger associated with the model, then providing a bias indication. The patent contains 20 claims and covers technology used in ML model evaluation workflows.

Microsoft AI Patent Mitigates Stochasticity in Deployed Agents

USPTO granted Patent US12607973B2 to Microsoft Technology Licensing, LLC on April 21, 2026. The patent covers techniques for mitigating stochasticity when controlling mechanical systems with AI agents, including temporal segmentation of stochasticity into near-term and long-term categories with corresponding mitigation strategies such as reward function changes and margin application.

USPTO Grants Google AI Image-Text Embedding Patent

The USPTO granted patent US12608418B2 to Google LLC on April 21, 2026, covering methods for training image-text embedding models using training data that includes image pairs and selection data indicating co-click rates and similar-image click rates. The patent lists ten inventors including Zhen Li, Yi-Ting Chen, and Da-Cheng Juan.

Microsoft AI Predicts Body Motion, Granted US12608073B2

The USPTO granted US Patent 12,608,073B2 to Microsoft Technology Licensing, LLC on April 21, 2026. The patent covers an AI motion prediction system using reference joint poses and mask tokens to predict body motion trajectories for articulated entities. The 20-claim patent, filed February 3, 2023, is classified under CPC G06N 3/08 and relates to machine learning applications for motion modeling.

Google PCA Patent for Large-Scale Data Processing

The USPTO granted Patent US12608444B2 to Google LLC for a method of automated selection of principal component analysis (PCA) variants for large-scale datasets. The patent covers receiving a PCA request, training a PCA model on input features, determining principal components, generating embedded features, and returning those features to the user. The patent was filed on July 29, 2022, under application number 17816288, with 14 claims.

OpenAI US12608439B2 Patent: Transposed Matrix-Vector Multiplication

USPTO granted Patent US12608439B2 to OpenAI OpCo, LLC on April 21, 2026. The patent covers a system and method for performing vector-matrix multiplication (VMM) where the matrix transpose for stationary weights can be computed without moving data in memory. The patent includes 20 claims and has been assigned CPC classifications in AI/neural network hardware acceleration.

IBM AI Patent, Real-Time Air Temperature Forecasting

The USPTO granted US Patent 12,607,771B2 to International Business Machines Corporation on April 21, 2026. The patent covers a system and method for dynamically forecasting high spatial resolution air temperature in real-time using multiple data sources, generative adversarial networks for spatial downscaling, and physics-informed neural networks with extended Kalman filters for temporal forecasting. The patent contains 19 claims.

Combinatorial Optimization Patent - TOHOKU University, April 21 2026

The USPTO granted patent US12608438B2 to TOHOKU UNIVERSITY for a combinatorial optimization problem processing apparatus, method, and program. The patent covers an annealing scheme for solving combinatorial optimization problems including third-or-higher-order terms in the Hamiltonian using an alternate optimization algorithm. The patent contains 11 claims and is classified under CPC groups G06N 5/01, G06N 7/00-01, and G06N 10/00-60, with applications in supply chain optimization (G06Q 10/04-047).

US12608684B2 Real-Time Discussion Window Operation Method and Device

USPTO granted patent US12608684B2 to United Microelectronics Corp. on April 21, 2026. The patent covers an operation method and device for real-time discussion windows, including obtaining discussion topics from initiators, providing participant suggestion lists, and automatically generating discussion reports. The patent contains 12 claims and has a filing date of January 5, 2024.

Humana Granted US Patent for ML Data Processing Platform

The USPTO granted Patent US12608645B1 to Humana Inc. on April 21, 2026, covering a machine learning platform for agile model development and standardized data processing. The patent application was filed on May 23, 2022, under Application No. 17751569, with 10 claims allowed.

Capital One ML Patent: Dataset Performance Change Using Machine Learning

The USPTO granted US Patent 12608446B2 to Capital One Services, LLC covering methods for determining performance change within datasets using machine learning models. The patent addresses training machine learning models on control datasets and applying test datasets to detect performance shifts attributable to applied conditions. The patent was filed December 21, 2021, with Application No. 17557599, and contains 14 claims.

ML Model Selection Based on Feature Merging, Spatial Location

USPTO granted patent US12608442B2 to inventor Jiazuo Zhang for a method of selecting machine learning models in wellbore operations using feature merging across multiple time windows. The patent covers receiving sensor data from subsurface formations in wellbores, merging with previously cached historical datasets that spatially overlap, and selecting appropriate ML models based on merged datasets.

Element Biosciences PCR-Free Library Preparation Patent Granted

The USPTO granted US Patent 12,606,819B2 to Element Biosciences, Inc. covering compositions and methods for PCR-free library preparation using double-stranded splint adaptors. The patent claims double-stranded splint adaptor structures with long and short hybridized strands carrying adaptor sequences, as well as one-pot multi-enzyme reaction workflows for introducing new adaptor sequences into library molecules. The patent contains 30 claims across CPC classifications including C12N 15/1065 and C12Q 1/6855.

Modified Cpf1 Guide RNA CRISPR Gene Editing Patent

The USPTO granted Patent US12606823B2 to inventor Kunwoo Lee covering a nucleic acid comprising a Cpf1 crRNA, a processing sequence 5′ of the Cpf1 crRNA, and an extension sequence 5′ of the processing sequence. The patent also covers compositions comprising the nucleic acid with a carrier and optionally Cpf1, as well as methods of genetically modifying eukaryotic target cells. The patent contains 29 claims and was filed on October 2, 2018.

Methods of Creating and Screening DNA-Encoded Libraries

The USPTO granted Patent US12606817B2 to X-Chem, Inc. (inventor: Richard W. Wagner) for methods of creating and screening DNA-encoded libraries for drug discovery applications. The patent contains 17 claims covering synthesis and screening methodologies that link functional moieties to initiator oligonucleotides for target binding identification. The filing date was June 19, 2020, with application number 16906626.

City of Hope AAV Bioreactor Patent US12606784B2

USPTO granted patent US12606784B2 to City of Hope for a cell cultivation apparatus and method for high-density cell growth and adeno-associated virus (AAV) production. The apparatus includes a membrane with surface features for cell placement, a gas-permeable material, and compartments configured to reduce media flow shear forces on cells. The patent names Colin Andrew Cook, Yuman Fong, Yu-Chong Tai, and Saswati Chatterjee as inventors.

UMass RPGR Gene Therapy Patent US12606825B2

The USPTO granted patent US12606825B2 to University of Massachusetts covering compositions and methods for modulating RPGR (retinitis pigmentosa GTPase regulator) expression for treating retinitis pigmentosa. The patent includes expression vectors encoding RPGR proteins and inhibitory nucleic acids targeting RPGRCONST isoforms. The application was filed on March 4, 2021, with 16 claims granted.

ENGINZYME AB Biocatalyst CPS Silica Patent US12606812B2

USPTO granted patent US12606812B2 to ENGINZYME AB on April 21, 2026, covering a biocatalyst composition for organic synthesis. The invention comprises controlled porosity silica (CPS) as support material with pore diameters between 20 and 100 nm, an amino-functionalized surface, and one or more immobilized catalytically active enzymes. The patent includes three claims and covers methods of manufacture and uses.

Tsinghua University Mirror Nucleic Acid Replication Patent

The USPTO granted Patent No. US12606808B2 to Tsinghua University for a method of replicating mirror nucleic acids. The patent covers reacting a mirror nucleic acid template, a mirror nucleic acid primer, and mirror dNTPs/rNTPs in the presence of a mirror nucleic acid polymerase. The patent contains 12 claims and was filed on May 31, 2022.

BASF SE Amylase Enzymes, Granted 21st Apr

The United States Patent and Trademark Office granted patent US12606809B2 to BASF SE on April 21, 2026. The patent covers genetically engineered amylase enzymes, compositions comprising the enzymes, and methods of making and using them. Applications include laundry detergents, dish washing detergents, cleaning products, baking, animal feed, pulp and paper processing, starch processing, brewing, and ethanol production. The application was filed on March 24, 2020, under application number 17442675.

US12606818B2: Illumina Granted, Nucleic Acid Sequencing Methods

The USPTO granted US Patent 12,606,818B2 to Illumina, Inc. on April 21, 2026. The patent covers methods and compositions for preparing nucleic acid templates and obtaining sequence data therefrom, with 29 claims. The application was filed on January 12, 2023.

US12606798B2 - Stem Cell Differentiation Methods and Compositions

USPTO granted US Patent 12606798B2 to Wisconsin Alumni Research Foundation covering methods and compositions for differentiating pluripotent stem cells into endothelial and hematopoietic lineages under defined conditions. The patent lists Igor Slukvin and Gene Ichiro Uenishi as inventors and contains 9 claims.

Bioactive Phenolate Ionic Complexes, 21 Claims, US12606536B2

The USPTO granted Patent US12606536B2 to Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. for bioactive phenolate ionic complexes. The patent covers isolated materials comprising phenolate species and counter ions in the form of metal salts, phosphonium, or ammonium. Twenty-one claims were allowed.

Process for Preparation of Apalutamide, Synthon B.V., Apr 21

The USPTO granted patent US12606539B2 to Synthon B.V. (a Dutch biopharmaceutical company) for a process to synthesize Apalutamide, along with its solid forms, salts, and solvates, and intermediates used therein. The patent application (18043777) was filed September 3, 2021, and carries 14 claims under CPC classifications C07D 401/04 and C07C 229/48. This grant gives Synthon B.V. exclusionary rights over this synthetic route for the prostate cancer drug.

Duk San Neolux Patent Granted, C07D Compound

The USPTO granted Patent US12610737B2 to DUK SAN NEOLUX CO., LTD. on April 21, 2026. The patent covers a compound of Formula 1 classified under C07D 251/24, designed for use in organic electronic elements. The invention aims to improve luminescence efficiency, stability, and lifespan of organic electronic elements.

L'OREAL Patent: C-Glycoside Keratin Treatment

USPTO granted Patent US12606534B2 to L'OREAL covering C-glycoside derivatives for cosmetic treatment of keratin materials including skin whitening, lightening, and depigmenting applications. The patent names Marie-céline Frantz, Maria Dalko, and Alexandre Cavezza as inventors with claims directed to compounds of formula (I) where R is as defined and S* is a mono or polysaccharide. The patent contains 6 claims and covers cosmetic compositions for non-therapeutic skin treatment uses.

Discectomy Tool Patent US12605178B2 Granted Apr 21

The USPTO granted Patent US12605178B2 to Combination Spine, Inc. for a discectomy tool designed to clear material from a patient's disc space. The device features dual rotatable members at the distal portion with a transverse axis, an actuation mechanism for rotation, and an expansion feature to increase inter-member distance. The patent names Joshua M. Ammerman and Richard Briganti as inventors and contains 29 claims.

Femoral Head Restoration Instrument, US12605170B2

The USPTO has granted Patent US12605170B2 to DePuy Ireland Unlimited Company. The patent covers a surgical instrument and method for assessing restoration of the femoral head centre during hip replacement surgery. The instrument comprises a body with a first connector for attaching to a femoral part, a plurality of apertures corresponding to respective femoral head centres, and a gauge with a pin and arm bearing a scale. The approach seeks to provide a simple method for restoring native femoral head position during hip replacement procedures.

Tactical Hemostatic Bandage Patent Granted to Solid Year Co

USPTO granted patent US12605164B2 to Solid Year Co., Ltd. on April 21, 2026, for a pressurized tourniquet comprising an elastic band, hemostatic dressing, and pressurized member. The invention features a through-tough on the outer surface of the elastic band and a detachable insertion portion on the pressurized member.

US12606640B2 - Recombinant Antimicrobial Polypeptide

The USPTO granted US Patent US12606640B2 to IRTA, Institut de Recerca i Transferència Agroalimentàries, covering a recombinant antimicrobial multidomain polypeptide comprising at least three peptidic domains — a non-enzymatic antimicrobial domain, a bacterial binding domain, and an enzymatic antimicrobial domain. The patent contains 21 claims and was filed on February 18, 2020.

Inhibitory T Cell Receptor Peptides and Discovery Methods

USPTO granted patent US12606816B2 to Janux Therapeutics, Inc. covering inhibitory T cell receptor peptides and methods of inhibiting T cell receptor interactions with peptide-major histocompatibility complexes. The patent discloses peptides that bind to T cell receptors without requiring major histocompatibility complex assistance. Six claims are associated with this patent.

Fish Totivirus Patent Granted to Pharmaq AS

The USPTO granted Patent US12606875B2 to Pharmaq AS on April 21, 2026, covering a novel fish Totivirus that causes mortality in fish and methods for detecting the virus. The patent names inventors Stian Nylund, Liv Sandlund, and Arnfinn L. Okland. The filing date was February 4, 2020, under Application No. 17433416, with 22 claims registered.

Method for Purifying Membrane Protein Complex - Sumitomo Patent US12606807B2

USPTO granted Patent US12606807B2 to Sumitomo Rubber Industries, Ltd. on April 21, 2026. The patent covers a method for purifying proteins derived from membrane protein complexes using synthetic polymers, antibodies, and pH-controlled elution with solvent extraction. The patent has 15 claims with a filing date of March 23, 2022.

Porous Silicon Nanoparticle Drug Delivery System with Reactive Oxygen Species Self-Activation, Kyung Hee University

The USPTO granted Patent US12605462B2 to the University-Industry Cooperation Group of Kyung Hee University for a porous silicon nanoparticle drug delivery system with isothiocyanate moiety conjugated to the surface. The invention generates reactive oxygen species in cells without an external initiator, promoting drug decomposition and release with low side effects due to high biocompatibility.

Regeneron Protein-Drug Conjugates Camptothecin Analogs Patent

The USPTO granted Regeneron Pharmaceuticals, Inc. Patent US12605459B2 covering protein-drug conjugates that combine camptothecin analogs with glutaminyl-modified antibodies for targeted therapeutic delivery. The patent describes methods for producing antibody-drug conjugates using transglutaminase and 1,3-cycloaddition techniques. The granted patent provides Regeneron exclusive rights to the disclosed compositions and methods, with two claims covering the conjugate structures and their therapeutic applications.

University of Minnesota Kinase Degradation Compounds for Cancer Treatment

USPTO granted Patent US12605452B2 to the Regents of the University of Minnesota on April 21, 2026. The patent covers compounds of Formula (I) or (II) comprising Aurora A or CDK4/6 ligands linked to E3 ligase ligands, along with pharmaceutical compositions and methods for treating cancer using such compounds. The patent contains 13 claims.

SYSTIMMUNE Antibody-Drug Conjugate Patent with Acidic Stabilization Junction

The USPTO granted Patent US12605458B2 to SYSTIMMUNE, Inc. on April 21, 2026, covering an antibody-drug conjugate with a hydrophilic acidic stabilization junction designed to maintain desired pharmacokinetic properties at higher drug loading. The patent, filed June 15, 2018, contains 18 claims and is classified under multiple therapeutic CPC codes including A61P 35/00 (anti-neoplastic), A61P 29/00 (anti-inflammatory), and A61P 37/02 (immunomodulators).

HIP1 Inhibitor Patent US12605456B2, Utah Valley University

The USPTO granted Patent US12605456B2 to Utah Valley University on April 21, 2026, covering inhibitor compounds that target the Huntingtin Interacting Protein 1 (HIP1) enzyme. The patented composition comprises a tripeptide targeting sequence directing the compound to HIP1's active site, conjugated to a C-terminal electrophilic warhead configured to inactivate the enzyme. The patent contains 20 claims.

US12605454B2 - Modified CMV VLPs as Vaccine Platform

USPTO granted Patent US12605454B2 to SAIBA AG for modified Cucumber Mosaic Virus (CMV) virus-like particles (VLPs) incorporating Th cell epitopes for enhanced immune responses as a vaccine platform. The 23-claim patent covers linking antigens to modified CMV VLPs to generate antibody responses. CPC classifications span infectious diseases, autoimmune conditions, metabolic disorders, and neurological applications. The patent application (17714307) was filed April 6, 2022.

Johns Hopkins Tolerogenic Antigen-Presenting Cell Patent US12605463B2

The USPTO granted patent US12605463B2 to Johns Hopkins University covering biodegradable particles designed to interact with immune cells and generate immunosuppressive effects. The particles include a polyester or polyester blend with soluble protein or small molecule encapsulated within, and two surface-attached protein types acting as Signal 1 and Signal 2 for immune cell binding and co-stimulation. The invention claims methods for inducing regulatory T cells and treating autoimmune diseases.

Actinium-225 Anti-CD45 Antibody Composition Patent Granted

The USPTO granted patent US12605472B2 to Actinium Pharmaceuticals, Inc. on April 21, 2026, covering compositions and methods for treating hematological diseases using actinium-225 labeled anti-CD45 antibody (BC8) formulated as a single patient dose. The patent claims 23 compositions and methods of use for treating hemoglobinopathies and hematological malignancies.

Surgical Tool Assembly With K-Wire Stabilization for Medical Implants

USPTO granted patent US12605257B2 to FORMAE, INC. on April 21, 2026. The patent covers a surgical tool assembly with guide tools configured to support instruments and receive K-wires for stabilizing the assembly during medical implant installation procedures. The patent contains 15 claims.

St. Jude Medical Patent: Stabilizing Wires Cardiac Device

USPTO granted patent US12605162B2 to St. Jude Medical, Cardiology Division, Inc. covering a medical device with stabilizing wires that are selectively movable between a first position extending radially outwardly and a second position retracted within the device body. The stabilizing wires include a linear portion, a hook portion at the distal end, and a ramp segment with incline and decline portions.

US12604970B2, Kiiroo BV, Adhesive Mount Patent Grant

The USPTO granted Patent US12604970B2 to Kiiroo BV on April 21, 2026. The patent covers an adhesive mount for attaching a device to skin, featuring a flexible adhesive layer and mounting elements. The application (18388346) was filed November 9, 2023, and the patent contains 20 claims.

Hemostasis Clip Release Patent - Boston Scientific

The USPTO granted Patent US12605163B2 to Boston Scientific Scimed, Inc. on April 21, 2026. The patent covers a hemostasis clip release system comprising an adapter mounted over a distal end of an insertion device, a clip with jaws movable between an insertion configuration and an initial deployed configuration, and a first extending member releasably coupled to the first jaw connection element. The system allows movement of the adapter relative to the clip while the first member remains coupled, enhancing visual observation of the clip during deployment.

Olympus Endoscope Suction Channel Design Patent Granted

The USPTO granted Olympus Corporation Patent US12605054B2 for an endoscope with a suction channel featuring a variable-diameter design. The suction channel includes a main body and a small-diameter distal portion satisfying the relational expression R1/R2>1.27, where R1 is the inner diameter of the channel main body and R2 is the inner diameter of the small-diameter channel portion. The patent contains 10 claims and covers technology for suctioning liquid along with crushed calculi during endoscopic procedures.

Edwards Lifesciences Heart Valve Repair Patent Granted

USPTO granted patent US12605248B2 to Edwards Lifesciences Corporation on April 21, 2026. The patent covers valve repair systems and leaflet clip devices for reducing regurgitation through native heart valves, including a delivery apparatus and clipping member that transforms from a delivery configuration to an implantation configuration via tensioning members. The patent names Lauren R. Freschauf and Ralph Schneider as inventors.

Avatar Medical Autostereoscopic Display Patent Granted

The USPTO granted patent US12605062B1 to Avatar Medical on April 21, 2026, covering a switchable autostereoscopic display system capable of rendering both stereoscopic 3D images and flat 2D images on a single display. The patent contains 15 claims and is classified under medical imaging CPC codes.

Balloon Device for Rigid Bronchoscope US12605060B1

The USPTO granted Patent US12605060B1 to inventors An Ho and David Stein for a balloon device configured for use with rigid bronchoscopes. The invention includes a balloon shaft member, a balloon member, and an inflation device, designed to fit snugly on the outside of a rigid bronchoscope to improve patient ventilation and prevent back bleeding during rigid bronchoscopy procedures.

Analyte Sensor Inserter Design Patent Granted April 21, 2026

The USPTO granted Design Patent USD1123164S1 for an analyte sensor inserter to inventors Shun Hui, Zhongyi Ding, and Guochang Li. The patent application (No. 35522868) was filed on October 18, 2024, and the design is classified under A61B 17/205, A61B 2017/925, and A61M 37/0015. One claim was allowed.