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KWS SAAT Immature Inflorescence Meristem Gene Editing

KWS SAAT SE & Co. KGaA has published a patent application (US20260098273A1) for a method of plant genome modification targeting immature inflorescence meristem (IIM) cells. The method uses genome editing systems with optional regeneration boosters, delivered via particle bombardment, to modify genomic target sites in plant cells and regenerate modified plant tissues, organs, or seeds.

Root-Mediated Uptake of Guide RNA for Genomic Editing of a Plant

USPTO published patent application US20260098274A1 by Inari Agriculture Technology disclosing methods for editing plant genomes by delivering guide RNA to plant roots for CRISPR-Cas editing in meristems. Inventors include Aran McCay, Michael Lee Nuccio, and Palak Kathiria. The filing date was March 7, 2024.

UORF Editing to Improve Crop Plant Agronomic Traits

USPTO published patent application US20260098275A1 assigned to Inari Agriculture Technology, Inc., disclosing methods of improving agronomic traits in crop plants through editing sequences within the 5' untranslated region (5' UTR) of plant genomes. The application names Ross Everett Altman, Malachy T. Campbell, Karl Anton Grothe Kremling, and Ruijuan Li as inventors. Filing date was April 10, 2024.

DNA Origami Nanostructures for Molecular Data Storage Patent Application

USPTO published patent application US20260098258A1 on April 9, 2026, disclosing compositions and methods using DNA origami principles to package and archive data stored in multiple indexed DNA oligonucleotides. The application (No. 19319178, filed September 4, 2025) covers DNA origami (DNAO) nanostructures enabling selective physical data access and retrieval from a molecular pool.

Cell-Free PPi-Driven ATP Regeneration Platform Patent

Cell-Free PPi-Driven ATP Regeneration Platform Patent

Methods for Assaying Enriched Nucleic Acids Using Complementary Probes

The USPTO published patent application US20260098304A1 covering methods for assaying enriched nucleic acids using probes with sequences complementary to RNA expression products to determine expression levels of multiple genes. The application was filed on October 3, 2024 by inventors including Charles M. Perou, Joel S. Parker, and others. The claimed methods enable enrichment of nucleic acid molecules for gene expression analysis in biological samples.

Protein Evolution System With DNA Synthesis, Microfluidics

The USPTO published patent application US20260098257A1 covering systems, methods, and kits for rapid protein evolution. The application (No. 19271120, filed July 16, 2025) names five inventors and describes a system combining DNA synthesis, microfluidic devices with sequestration pens, and a computing component for iterative protein optimization. The technology enables cell-free protein expression and assay-based evaluation of protein variants.

CHIMERIC ANTIGEN RECEPTOR SPACERS

The USPTO published Lyell Immunopharma's patent application US20260098075A1 for chimeric antigen receptors (CARs) incorporating immunoglobulin-derived spacers, such as hinge or loop regions, designed to enhance cytokine release compared to CARs with non-Ig-derived spacers. The spacers may be derived from human immunoglobulins (IgAQ1, IgA2, IgD, IgE, IgG1-4, IgM) or non-human sources (e.g., mouse IgG2A), and may be configured as modular constructs combining multiple Ig hinges or fragments thereof. Filed September 8, 2025.

Novel Formulations and Vehicles for DAPTZ Compounds Including Methylene Blue

USPTO published patent application US20260097043A1 assigned to WisTa Laboratories Ltd., covering novel oral pharmaceutical formulations of diaminophenothiazine (DAPTZ) compounds such as methylene blue. The application discloses gastro-retentive platforms including film-coated solid tablets and buoyant self-orientating capsules with sustained-release coatings. The filing was submitted on September 20, 2023, under application number 19113777.

Cancer Therapy Delivery System with Tumbling Container for Suspension Generation

USPTO published patent application US20260096951A1 for a cancer therapy delivery system featuring a tumbler vial for generating therapeutic microsphere suspensions. The system includes a rotation mechanism, fluid inlet and outlet lines configured to twist during rotation, and a cap occluding the vial end. The application was filed on October 9, 2025.