Protein Evolution System With DNA Synthesis, Microfluidics
Summary
The USPTO published patent application US20260098257A1 covering systems, methods, and kits for rapid protein evolution. The application (No. 19271120, filed July 16, 2025) names five inventors and describes a system combining DNA synthesis, microfluidic devices with sequestration pens, and a computing component for iterative protein optimization. The technology enables cell-free protein expression and assay-based evaluation of protein variants.
What changed
The USPTO published a patent application (US20260098257A1) for a protein evolution system incorporating DNA synthesis, a microfluidic device with sequestration pens, and a computing component for assay analysis and improved DNA sequence design. The system enables correlation of DNA sequence location on a bead within the microfluidic device, cell-free protein expression, and protein assay evaluation. Application No. 19271120 was filed July 16, 2025 and published April 9, 2026.
Manufacturers and researchers in biotechnology and pharmaceutical development should monitor this application as it may indicate направление в области protein engineering tools. Patent applications do not yet confer enforceable IP rights; they signal potential future licensing or freedom-to-operate considerations.
What to do next
- Monitor for patent grant or office action
Archived snapshot
Apr 13, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
SYSTEMS AND METHODS FOR IDENTIFICATION OF OPTIMIZED PROTEIN PRODUCTION AND KITS THEREFOR
Application US20260098257A1 Kind: A1 Apr 09, 2026
Inventors
Jason M. MCEWEN, Troy A. LIONBERGER, Eric K. SACKMANN, Volker L.S. KURZ, Kellen C. MOBILIA
Abstract
Systems, methods, and kits therefor, enabling rapid protein evolution are described herein. A system useful in the methods described herein include a DNA synthesis component; a microfluidic system including a microfluidic device having a microfluidic channel and sequestration pens; and a computing component, which is configured to analyze assay results and, based upon the analysis, design improved DNA sequences for iterative protein evolution. The microfluidic system is configured to permit correlation of DNA sequence on a bead to its location within the microfluidic device, permit cell free protein expression of a DNA sequence captured to a bead, and to permit assay of the protein so produced.
CPC Classifications
C12N 15/1075 B01L 3/502761 C12N 15/1065 B01L 2200/0647
Filing Date
2025-07-16
Application No.
19271120
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