Methods for Assaying Enriched Nucleic Acids Using Complementary Probes
Summary
The USPTO published patent application US20260098304A1 covering methods for assaying enriched nucleic acids using probes with sequences complementary to RNA expression products to determine expression levels of multiple genes. The application was filed on October 3, 2024 by inventors including Charles M. Perou, Joel S. Parker, and others. The claimed methods enable enrichment of nucleic acid molecules for gene expression analysis in biological samples.
What changed
The USPTO published a patent application for methods of detecting RNA expression using complementary probes to assay enriched nucleic acids derived from biological samples. The application claims methods for determining expression levels of multiple genes through probe-based enrichment of RNA-derived nucleic acid molecules.
Competitors developing RNA-based diagnostics or gene expression analysis technologies should review the application claims for potential infringement risks and assess freedom to operate. This publication establishes a priority date of October 3, 2024 for the claimed inventions.
What to do next
- Monitor for patent grant
- Conduct freedom-to-operate analysis
Archived snapshot
Apr 13, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
METHODS FOR ASSAYING ENRICHED NUCLEIC ACIDS
Application US20260098304A1 Kind: A1 Apr 09, 2026
Inventors
Charles M. Perou, Joel S. Parker, James Stephen Marron, Andrew Nobel, Philip S. Bernard, Matthew J. Ellis, Elaine Mardis, Torsten O. Nielsen, Maggie Chon U. Cheang
Abstract
In an aspect, a method comprises providing a biological sample of a subject, and assaying nucleic acid molecules derived from RNA expression products of the biological sample to determine an RNA expression level of a plurality of genes, wherein the assaying comprises use of probes having sequences complementary to the nucleic acid molecules derived from the RNA expression products, to enrich the nucleic acid molecules for the plurality of genes.
CPC Classifications
C12Q 1/6886 C12N 15/1096 C12Q 1/6813 C12Q 1/6869 C12Q 2600/158
Filing Date
2024-10-03
Application No.
18905647
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