Predictors & Mechanisms of Adolescent PTSD - Early Phase 1 Clinical Trial NCT07537764
Summary
The NIH registered Early Phase 1 clinical trial NCT07537764 on ClinicalTrials.gov to study biobehavioral predictors and mechanisms of PTSD response in trauma-exposed adolescents. The study will assess brain activity, physiological responses, and behavior during experimental tasks involving threat reactivity, emotion regulation, and script-driven imagery. Findings may inform future exposure-based intervention development for adolescent PTSD.
What changed
The NIH registered a new clinical trial examining biobehavioral predictors and mechanisms of PTSD in trauma-exposed adolescents. The study involves experimental tasks with threat reactivity, emotion regulation, and repeated script-driven imagery to evaluate whether baseline patterns predict individual response to exposure-based interventions.
For clinical investigators and healthcare providers, this trial registration signals ongoing research into adolescent trauma responses and PTSD mechanisms. Results may inform the development of future exposure-based therapeutic interventions for adolescent PTSD populations.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Predictors & Mechanisms of Adolescent PTSD
Early Phase 1 NCT07537764 Kind: EARLY_PHASE1 Apr 17, 2026
Abstract
This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to potential threats, regulating emotions, and repeatedly imagining details of a personally experienced stressful or traumatic event using a script-driven imagery task.
The study evaluates whether repeated imaginal exposure is associated with changes in anxiety and physiological responses across sessions, and whether baseline patterns of threat reactivity and emotion regulation are associated with individual differences in response to the exposure task. Outcomes include self-reported anxiety, subjective distress ratings, and psychophysiological indices such as heart rate, skin conductance, and electromyographic activity.
The goal of this research is to improve understanding of biobehavioral processes related to trauma exposure in adolescents and to identify potential predictors of response to exposure-based intervention components relevant to posttraumatic stress disorder (PTSD).
Conditions: Posttraumatic Stress Disorder (PTSD), Trauma Exposure
Interventions: Repeated imaginal exposure: Script Driven Imagery (SDI) task
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