Amide EZH2 Inhibitor Patent - Preparation Method and Medical Applications

ChangeBridge: Patent Grants - Organic Chemistry (C07D)

Published April 7th, 2026

Detected April 7th, 2026

Summary

The USPTO granted patent US12595267B2 to Shanghai Synergy Pharmaceutical Sciences Co., Ltd. covering an amide small molecule compound that inhibits EZH2 (Zeste gene enhancer homolog 2). The patent protects methods for preparing the compound and its use in treating EZH2-mediated diseases including tumors, myeloproliferative diseases, and autoimmune diseases. The patent contains 11 claims and names 19 inventors.

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What changed

USPTO granted patent US12595267B2 to Shanghai Synergy Pharmaceutical Sciences Co., Ltd. for an amide compound acting as an EZH2 inhibitor. The compound may be used to prevent and/or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases. The patent protects both the preparation method and medical applications of the compound.

For pharmaceutical companies developing oncology or autoimmune therapies, this patent establishes intellectual property protection for EZH2 inhibitor compounds. Competitors in this therapeutic space should assess whether their development activities might infringe this granted patent. The 11-claim scope provides broad protection around the amide compound structure and its therapeutic applications, potentially affecting competitive landscape for EZH2-targeted drug development.

What to do next

Monitor patent portfolio for potential licensing opportunities
Review freedom-to-operate implications for competing EZH2 inhibitors

Source document (simplified)

← USPTO Patent Grants

Preparation method for amide compound and application thereof in field of medicine

Grant US12595267B2 Kind: B2 Apr 07, 2026

Assignee

SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.

Inventors

Xin Xu, Jia Chen, Zhen Zhang, Liming Zhang, Qimei Wu, Qingyun Jiang, Fengying Guo, Yuyun Zhang, Hao Yu, Ying Wang, Kang Sun, Chengxu Zang, Chenggang Qin, Xiaobo Zhou, Xiaojuan Zhang, Yijin Wang, Xiaoer Xia, Yunfei Li, Jian Ge

Abstract

The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and/or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.