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Benzo nitrogen-containing heteroaromatic ring derivative for complement factor B treatment

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Published April 7th, 2026
Detected April 7th, 2026
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Summary

The USPTO granted patent US12595270B2 to Xizang Haisco Pharmaceutical Co., Ltd. covering a benzo nitrogen-containing heteroaromatic ring derivative (general formula I) and its use in treating diseases associated with complement factor B activity or expression. The patent includes 8 claims encompassing the compound, stereoisomers, deuterates, solvates, prodrugs, metabolites, and pharmaceutically acceptable salts or co-crystals.

What changed

The USPTO issued patent US12595270B2 for a benzo nitrogen-containing heteroaromatic ring derivative as shown in general formula (I), covering the compound itself, stereoisomers, deuterates, solvates, prodrugs, metabolites, and pharmaceutical salts/co-crystals, along with intermediate compounds, preparation methods, and therapeutic applications for complement factor B-associated diseases. The patent carries CPC classifications spanning C07D heterocyclic chemistry (C07D 498/10, C07D 495/10, C07D 401/06, etc.) and A61K pharmaceutical compositions (A61K 31/438, A61K 31/454, etc.).

For pharmaceutical companies and researchers developing complement factor B inhibitors, this patent establishes intellectual property barriers around a specific heterocyclic compound family for therapeutic use. Competitors pursuing similar complement pathway targets must either design around these claims, pursue licensing arrangements with the assignee, or demonstrate non-infringement through alternative compound structures.

What to do next

  1. No immediate regulatory action required
  2. Monitor for potential licensing or clearance needs if developing competing complement factor B inhibitors

Source document (simplified)

← USPTO Patent Grants

Benzo nitrogen-containing heteroaromatic ring derivative and use thereof in medicine

Grant US12595270B2 Kind: B2 Apr 07, 2026

Assignee

Xizang Haisco Pharmaceutical Co., Ltd.

Inventors

Chen Zhang, Yuting Liao, Guozhi Zhu, Dachao Tang, Yan Yu, Pingming Tang, Xinfan Cheng, Yao Li, Jia Ni, Pangke Yan

Abstract

Provided are a compound as shown in general formula (I), or a stereoisomer, deuterate, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, an intermediate thereof, a preparation method therefor, and the use thereof in the preparation of a drug for treating a disease associated with the activity or expression quantity of complement factor B.

CPC Classifications

C07D 498/10 C07D 495/10 C07D 401/06 C07D 401/14 C07D 403/06 C07D 405/14 C07D 471/10 C07D 491/08 C07D 491/107 A61K 31/438 A61K 31/454 A61K 31/4545 A61K 31/496 A61K 31/5386 A61K 31/407

Filing Date

2025-10-07

Application No.

19352045

Claims

8

View original document →

Classification

Agency
USPTO
Published
April 7th, 2026
Instrument
Notice
Legal weight
Binding
Stage
Final
Change scope
Minor
Document ID
US12595270B2

Who this affects

Applies to
Pharmaceutical companies Drug manufacturers
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Patent grant IP licensing Drug development
Geographic scope
United States US

Taxonomy

Primary area
Intellectual Property
Operational domain
Legal
Topics
Pharmaceuticals Healthcare

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