Therapeutic Macrophages Patent Application

ChangeBridge: Patent Apps - Biotech (C12N)

Published March 26th, 2026

Detected March 27th, 2026

Summary

The USPTO has published a patent application (US20260085287A1) filed by Resolution Therapeutics Limited for therapeutic macrophages genetically engineered to overexpress Interleukin-10 (IL-10) or IL-10 in combination with Matrix Metallopeptidase 9 (MMP9). This application relates to potential treatments for inflammatory conditions.

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What changed

This document is a publication of a patent application filed by Resolution Therapeutics Limited. The application, identified as US20260085287A1, describes therapeutic macrophages engineered to overexpress IL-10 or a combination of IL-10 and MMP9. The intended use is for treating inflammatory conditions, including those with acute or chronic inflammation and fibrotic elements, such as inflammatory organ damage.

As this is a patent application publication, there are no immediate compliance obligations for regulated entities. However, companies in the pharmaceutical and biotechnology sectors should monitor this application and related patents for potential future intellectual property developments and licensing opportunities. The filing date was September 27, 2023, and the publication date is March 26, 2026.

Source document (simplified)

← USPTO Patent Applications

THERAPEUTIC MACROPHAGES

Application US20260085287A1 Kind: A1 Mar 26, 2026

Assignee

Resolution Therapeutics Limited

Inventors

Lara CAMPANA, Kayleigh THIRLWELL, Niya EKSANDROVA ALEKSIEVA, Rafael Alejandro ARMESILLA DIAZ, Hollie BARTLEY

Abstract

The present invention relates to a macrophage, genetically engineered to overexpress Interleukin-10 (IL-10) or IL-10 in combination with Matrix Metallopeptidase 9 (MMP9). Such a macrophage may be for use in treatment of an inflammatory condition in a subject such as inflammatory organ damage. The inflammatory condition may be acute or chronic and may involve a fibrotic element.

CPC Classifications

C12N 5/0645 A61K 35/15 A61K 40/17 A61K 40/50 A61P 1/16 C07K 14/5428 C12N 5/10 C12N 5/562 C12N 9/6489 C12N 15/85 C12Y 304/24035 C12N 2501/22 C12N 2501/2304 C12N 2501/2313 C12N 2510/00