THERAPEUTIC MACROPHAGES
Application
US20260085287A1
Kind: A1
Mar 26, 2026
Assignee
Resolution Therapeutics Limited
Inventors
Lara CAMPANA, Kayleigh THIRLWELL, Niya EKSANDROVA ALEKSIEVA, Rafael Alejandro ARMESILLA DIAZ, Hollie BARTLEY
Abstract
The present invention relates to a macrophage, genetically engineered to overexpress Interleukin-10 (IL-10) or IL-10 in combination with Matrix Metallopeptidase 9 (MMP9). Such a macrophage may be for use in treatment of an inflammatory condition in a subject such as inflammatory organ damage. The inflammatory condition may be acute or chronic and may involve a fibrotic element.
CPC Classifications
C12N 5/0645
A61K 35/15
A61K 40/17
A61K 40/50
A61P 1/16
C07K 14/5428
C12N 5/10
C12N 5/562
C12N 9/6489
C12N 15/85
C12Y 304/24035
C12N 2501/22
C12N 2501/2304
C12N 2501/2313
C12N 2510/00
Filing Date
2023-09-27
Application No.
19112932