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Patent Application: Spray Dried Lipid Nanoparticle Formulations

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Published September 16th, 2025
Detected March 26th, 2026
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Summary

The USPTO has published a patent application (US20260083681A1) detailing formulations for spray-dried lipid nanoparticle matrix particles. The application, filed on September 16, 2025, describes a composition including lipid nanoparticles, a buffer system, and a barrier matrix stabilizer. This publication is part of the patent application process and does not represent a final grant or regulatory requirement.

What changed

The United States Patent and Trademark Office (USPTO) has published a patent application, identified as US20260083681A1, concerning novel formulations for spray-dried lipid nanoparticles. The application details a composition comprising lipid nanoparticles, a buffer system, and a barrier matrix stabilizer, with specific parameters for the stabilizer based on osmolarity and injectable volume. The filing date for this application was September 16, 2025.

This publication represents a step in the patent application process and does not impose any immediate regulatory obligations or compliance requirements on pharmaceutical companies. It signifies that an invention related to drug formulation has been disclosed and is undergoing examination. Companies involved in pharmaceutical development, particularly those working with lipid nanoparticle delivery systems, may wish to review this application for potential intellectual property insights or to understand emerging technologies in the field.

Source document (simplified)

← USPTO Patent Applications

FORMULATIONS OF SPRAY DRIED LIPID NANOPARTICLES

Application US20260083681A1 Kind: A1 Mar 26, 2026

Inventors

Mark Kastantin, Dan Smithey, Erica Schlesinger, Ryan Mowry

Abstract

A formulation is provided for a spray dried lipid nanoparticle matrix particles, including lipid nanoparticles, a buffer system, and a barrier matrix stabilizer, wherein the barrier matrix stabilizer is included in a solid weight percent based on a maximum osmolarity and a maximum acceptable injectable volume of an injectable formulation comprising the spray dried lipid nanoparticle matrix particles.

CPC Classifications

A61K 9/5123 A61K 9/0019 A61K 9/5161 A61K 9/5192 A61K 31/7105

Filing Date

2025-09-16

Application No.

19330723

View original document →

Named provisions

FORMULATIONS OF SPRAY DRIED LIPID NANOPARTICLES

Classification

Agency
USPTO
Published
September 16th, 2025
Instrument
Notice
Legal weight
Non-binding
Stage
Draft
Change scope
Minor
Document ID
US20260083681A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Formulation
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Compliance frameworks
FDA 21 CFR Part 11
Topics
Drug Delivery Intellectual Property

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