Patent Application for mRNA Design

ChangeBridge: Patent Apps - Biotech (C12N)

Published September 5th, 2023

Detected March 27th, 2026

Summary

The USPTO has published patent application US20260088125A1 concerning methods for designing synthetic RNA molecules, specifically for mRNA design. The application details a process for obtaining coding sequences and selecting regions for synthetic RNA molecule production.

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What changed

This document is a published patent application from the USPTO detailing a novel method for designing selectively translated mRNA molecules. The application, filed on September 5, 2023, outlines a process involving obtaining a coding sequence for a protein of interest, identifying a specific RNA sequence expressed in certain tissues, and then producing a synthetic RNA molecule with defined 5' and 3' regions and a loop region. The invention also includes synthetic RNA molecules produced by this method and related computer program products.

While this is a patent application and not a regulation, it signifies potential future developments in mRNA technology. Companies involved in biotechnology and pharmaceutical research, particularly those working with mRNA therapeutics or vaccines, should be aware of this filing as it may impact future intellectual property landscapes and technological advancements in the field. No immediate compliance actions are required, but monitoring patent filings in this area is advisable for R&D strategy.

Source document (simplified)

← USPTO Patent Applications

DESIGN OF SELECTIVELY TRANSLATED mRNAS

Application US20260088125A1 Kind: A1 Mar 26, 2026

Inventors

Tamir TULLER, Matan ARBEL, Yehuda LANDAU, Efi MOREE

Abstract

Methods of designing a synthetic RNA molecule comprising obtaining a coding sequence encoding a protein of interest; obtaining a sequence of an RNA expressed in a first tissue or cell type and not expressed or lowly expressed in a second tissue or cell type; selecting a region within the sequence of an RNA; and producing a sequence of a synthetic RNA molecule comprising from 5′ to 3′: a reverse complement to the selected region comprising a 5′ unhybridized region and a 3′ hybridized region, a loop region that does not hybridize; a region reverse complementary to 3′ hybridized region and the obtained coding sequence encoding a protein of interest are provided. Synthetic RNA molecules produced by a method of the invention and computer program products for perform a method of the invention are also provided.