BacPROTACs for Targeted Protein Degradation in Bacteria
Summary
Washington University published patent application US20260091118A1 for bivalent agents (BacPROTACs) designed for targeted protein degradation in mycobacteria and other bacteria, including methods for reducing antibiotic resistance. The application (No. 19312129, filed August 27, 2025) covers compositions and methods for treating antibiotic-resistant bacterial infections.
What changed
Washington University filed patent application US20260091118A1 disclosing bivalent BacPROTAC agents capable of targeted protein degradation in mycobacteria and other bacteria. The application claims methods for reducing antibiotic resistance associated with bacterial infections and methods of treating antibiotic-resistant bacterial infections. Inventors include Timothy Wencewicz, Emily Williford, Helen Blaine, and Christina Stallings.
This is a patent application publication with no regulatory compliance requirements. Companies developing antibiotics or degradation-based therapeutics may wish to review the claims to assess potential freedom-to-operate considerations. The filing date was August 27, 2025, with publication on April 2, 2026.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Methods for Preparation and Use of BacPROTACs for Targeted Protein Degradation in Mycobacteria and Other Bacteria
Application US20260091118A1 Kind: A1 Apr 02, 2026
Assignee
Washington University
Inventors
Timothy Wencewicz, Emily Williford, Helen Blaine, Christina Stallings
Abstract
Among the various aspects of the present disclosure is the provision of bivalent agents for targeted protein degradation. Also disclosed are compositions including the bivalent agents and methods of use, including methods of reducing antibiotic resistance associated with an antibiotic-resistant bacterial infection and methods of treating an antibiotic-resistant bacterial infection.
CPC Classifications
A61K 47/552 A61K 47/543 A61K 47/60 A61P 31/04
Filing Date
2025-08-27
Application No.
19312129
Named provisions
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