Platinum-based drug/photosensitizer-loaded protein nanoparticle patent granted to Soochow University

ChangeBridge: Patent Grants - Pharma (A61K)

Published April 7th, 2026

Detected April 7th, 2026

Summary

USPTO granted patent US12594335B2 to Soochow University on April 7, 2026, covering platinum-based drug/photosensitizer-loaded protein nanoparticles for combined chemotherapy and photodynamic tumor treatment. The invention includes 6 claims for nanoparticles with platinum-based drugs and photosensitizers encapsulated in protein carriers. Filing date was July 24, 2020, with application number 18012295.

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What changed

USPTO granted patent US12594335B2 to Soochow University for platinum-based drug/photosensitizer-loaded protein nanoparticles and their preparation methods for tumor treatment. The patented technology combines chemotherapy with photodynamic therapy using protein-encapsulated nanoparticles that demonstrate tumor targeting, reduced side effects, and inhibition of tumor metastasis. The patent contains 6 claims and is classified under A61K 9/5169, A61K 33/243, and A61P 35/00.\n\nPharmaceutical manufacturers and researchers developing nanoparticle-based cancer therapeutics should conduct freedom-to-operate analyses to assess potential infringement risks. Medical device manufacturers in targeted drug delivery may also need to evaluate this patent when developing similar nanoparticle systems. The patent creates IP barriers in the combined chemotherapy-photodynamic therapy space, potentially affecting R&D strategies and partnership discussions in this field.

What to do next

Conduct freedom-to-operate analysis for nanoparticle-based tumor therapeutics
Review patent claims for potential licensing opportunities
Monitor similar patents in the nanoparticle drug delivery space

Source document (simplified)

← USPTO Patent Grants

Platinum-based drug-/photosensitizer-loaded protein nanoparticle, and preparation method therefor and application thereof

Grant US12594335B2 Kind: B2 Apr 07, 2026

Assignee

SOOCHOW UNIVERSITY

Inventors

Hong Yang, Tao Xu, Huabing Chen, Miya Zhang, Liang Chen, Yibin Deng, Jialu Yao, Jiali Luo, Yanhua Zhai

Abstract

A platinum-based drug/photosensitizer-loaded protein nanoparticle, and a preparation method therefor and an application thereof. The platinum-based drug/photosensitizer-loaded protein nanoparticle includes a platinum-based drug/photosensitizer complex, and a protein that encapsulates the platinum-based drug/photosensitizer complex. The prepared nanoparticles have a small particle size, are evenly dispersed and round in shape, and have good chemical stability, light stability, and high active oxygen generation capability when irradiated by near-infrared light; in cell experiments and animal experiments, it is verified that strong cytotoxicity to tumor cells and good in vivo tumor targeting are achieved, a synergistic effect is exerted, toxic and side effects are reduced, the use of chemotherapy and photodynamic therapy in combination to treat tumors is achieved, and metastasis of tumors is inhibited.