Mitochondria-targeted atovagone compounds and methods for antitumor, antimicrobial, and antimalarial treatment
Summary
USPTO granted Patent US12594283B2 to The Medical College of Wisconsin, Inc. covering mitochondria-targeted Atovaquone compounds (Mito-ATO) and methods of using such compounds for antitumor, antimicrobial, and antimalarial treatment. The patent contains 22 claims and was filed on October 26, 2020.
What changed
USPTO issued Patent US12594283B2 for novel mitochondria-targeted Atovaquone derivatives invented by Balaraman Kalyanaraman, Gang Cheng, and Micael Joël Hardy. The patent covers methods of treating cancer, enhancing anti-tumor immune responses, and antimicrobial/antimalarial applications using Mito-ATO compounds.
The patent grant establishes legally enforceable intellectual property rights for the Medical College of Wisconsin, preventing unauthorized manufacture, use, or sale of the claimed compounds and methods. Competitors in the pharmaceutical space should monitor this IP landscape when developing related therapeutic programs.
What to do next
- Monitor for updates
Archived snapshot
Apr 7, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Mitochondria-targeted atovagone: a more potent and more effective antitumor, antimicrobial, and antimalarial drug
Grant US12594283B2 Kind: B2 Apr 07, 2026
Assignee
The Medical College of Wisconsin, Inc.
Inventors
Balaraman Kalyanaraman, Gang Cheng, Micael Joël Hardy
Abstract
The present invention provides novel mitochondria-targeted Atovaquone compounds (Mito-ATO), a mitochondria-targeted derivative of Atovaquone, and methods of using such compounds. Methods of treating cancer using mito-ATO are also provided. Methods of enhancing an anti-tumor immune response by administering mito-ATO are further provided.
CPC Classifications
A61K 31/66 A61K 31/122 A61K 45/06 A61K 31/662 A61P 35/00 C07C 49/84 C07F 9/535 C07F 9/5435 C07F 9/5456
Filing Date
2020-10-26
Application No.
17770924
Claims
22
Related changes
Get daily alerts for ChangeBridge: Patent Grants - Therapeutics (A61P)
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
Source
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from USPTO.
The plain-English summary, classification, and "what to do next" steps are AI-generated from the original text. Cite the source document, not the AI analysis.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when ChangeBridge: Patent Grants - Therapeutics (A61P) publishes new changes.