Methods for Preparation and Use of BacPROTACs for Targeted Protein Degradation in Mycobacteria and Other Bacteria

Abstract

Among the various aspects of the present disclosure is the provision of bivalent agents for targeted protein degradation. Also disclosed are compositions including the bivalent agents and methods of use, including methods of reducing antibiotic resistance associated with an antibiotic-resistant bacterial infection and methods of treating an antibiotic-resistant bacterial infection.

CPC Classifications