City of Hope AAV Bioreactor Patent US12606784B2
Summary
USPTO granted patent US12606784B2 to City of Hope for a cell cultivation apparatus and method for high-density cell growth and adeno-associated virus (AAV) production. The apparatus includes a membrane with surface features for cell placement, a gas-permeable material, and compartments configured to reduce media flow shear forces on cells. The patent names Colin Andrew Cook, Yuman Fong, Yu-Chong Tai, and Saswati Chatterjee as inventors.
“A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided.”
What changed
USPTO granted patent US12606784B2 to City of Hope for a cell cultivation apparatus designed for high-density cell growth and intensified production of adeno-associated viruses. The apparatus features a membrane with multiple surface features on a first side for cell placement, with the membrane being at least partially permeable to gas. The compartments are configured to reduce media flow shear forces on cells.
For parties interested in biopharmaceutical manufacturing or viral vector production, this patent establishes intellectual property rights that may affect licensing discussions or freedom-to-operate analyses for competing AAV production technologies.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
System, device and method for production of bioproduct including high density cell respirator for intensified production of adeno-associated viruses
Grant US12606784B2 Kind: B2 Apr 21, 2026
Assignee
City of Hope
Inventors
Colin Andrew Cook, Yuman Fong, Yu-Chong Tai, Saswati Chatterjee
Abstract
A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.
CPC Classifications
C12M 23/34 C12M 23/08 C12M 23/10 C12M 23/24 C12M 23/38 C12M 23/58 C12M 25/04 C12M 25/06 C12N 5/0602
Filing Date
2020-11-13
Application No.
17776183
Claims
31
Mentioned entities
Parties
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