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City of Hope AAV Bioreactor Patent US12606784B2

USPTO granted patent US12606784B2 to City of Hope for a cell cultivation apparatus and method for high-density cell growth and adeno-associated virus (AAV) production. The apparatus includes a membrane with surface features for cell placement, a gas-permeable material, and compartments configured to reduce media flow shear forces on cells. The patent names Colin Andrew Cook, Yuman Fong, Yu-Chong Tai, and Saswati Chatterjee as inventors.