Method for Purifying Membrane Protein Complex - Sumitomo Patent US12606807B2
Summary
USPTO granted Patent US12606807B2 to Sumitomo Rubber Industries, Ltd. on April 21, 2026. The patent covers a method for purifying proteins derived from membrane protein complexes using synthetic polymers, antibodies, and pH-controlled elution with solvent extraction. The patent has 15 claims with a filing date of March 23, 2022.
What changed
USPTO granted Patent US12606807B2 to Sumitomo Rubber Industries, Ltd. for a method of purifying proteins derived from membrane protein complexes. The method involves binding a membrane protein complex to an antibody after elution using a synthetic polymer, followed by elution at pH 6.0 or higher and solvent extraction at pH 7.0 or lower to remove the synthetic polymer.
Pharmaceutical and biotechnology companies developing membrane protein-based therapeutics may find this method relevant for maintaining complex integrity during purification. Competitors should note that alternative purification approaches remain available under separate patent strategies.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Method for purifying protein derived from membrane protein complex
Grant US12606807B2 Kind: B2 Apr 21, 2026
Assignee
SUMITOMO RUBBER INDUSTRIES, LTD.
Inventors
Haruhiko Yamaguchi, Yukino Inoue, Seiji Takahashi, Toru Nakayama
Abstract
The present disclosure aims to provide a method which, even when a protein complex is formed, can purify a protein derived from such a membrane protein complex by eluting the membrane protein complex maintaining its complex form. The present disclosure relates to a method for purifying a protein derived from a membrane protein complex, which includes: a protein binding step of binding to an antibody a membrane protein complex eluted from a membrane using a synthetic polymer; a protein eluting step of eluting the membrane protein complex bound to the antibody in the protein binding step at a pH of 6.0 or higher; and a synthetic polymer removing step of subjecting the membrane protein complex eluted in the protein eluting step to solvent extraction at a pH of 7.0 or lower to remove the synthetic polymer.
CPC Classifications
C07K 1/14 C12N 9/10 C12N 9/1085
Filing Date
2022-03-23
Application No.
18283332
Claims
15
Parties
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