Process for Preparation of Apalutamide, Synthon B.V., Apr 21

The USPTO granted patent US12606539B2 to Synthon B.V. on April 21, 2026, covering a process for preparing Apalutamide (compound 1), its salts and solvates, and solid forms thereof, as well as solid forms of intermediates used in the preparation process. The patent application was filed September 3, 2021 (Application No. 18043777) and contains 14 claims classified under C07D 401/04 and C07C 229/48.\n\nPharmaceutical companies engaged in API or intermediate manufacturing should review freedom-to-operate positions in light of this newly granted patent. Patent holders and licensees may need to assess whether this process patent creates any overlap with or obstacle to existing IP strategies or licensing arrangements.