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Process for Preparation of Apalutamide, Synthon B.V., Apr 21

The USPTO granted patent US12606539B2 to Synthon B.V. (a Dutch biopharmaceutical company) for a process to synthesize Apalutamide, along with its solid forms, salts, and solvates, and intermediates used therein. The patent application (18043777) was filed September 3, 2021, and carries 14 claims under CPC classifications C07D 401/04 and C07C 229/48. This grant gives Synthon B.V. exclusionary rights over this synthetic route for the prostate cancer drug.