Healthcare & Life Sciences

Methods for Controlling Treatment Volumes in Pulsed Electric Field Treatments

USPTO granted Patent US12599429B2 to North Carolina State University covering methods for electrotherapy via pulsed electric field. The patent describes modifying or killing target cells while simultaneously controlling treatment volumes, thermal gradients, muscle stimulation, and immune responses through dynamically adjusted electrical pulse delivery profiles. The patent contains 20 claims.

Boston Scientific Patent US12599435B2 for Catheter Ablation Using Irreversible Electroporation

USPTO granted patent US12599435B2 to Boston Scientific Scimed, Inc. on April 14, 2026, for catheter systems and methods using pulsed DC voltage to drive irreversible electroporation for selective tissue ablation. The patent includes claims covering voltage pulse generators, electrode controllers with selection and pulse delivery modules, and methods for delivering pulsed voltage waveforms to selected electrodes.

Pre-Procedure Planning, Intra-Procedure Guidance for Biopsy and Ablation

USPTO granted Patent US12599437B2 to Covidien LP covering a system and method for navigation of a luminal network for pre-procedure planning and intra-procedure guidance during biopsy and ablation of tumors. The system uses CT image data, generates 3D models, and provides real-time catheter sensor location registration for navigation to tumors. The patent includes 20 claims and covers technology for use with or without cone-beam CT or fluoroscopic imaging.

Stent End Point Locations System

USPTO granted Koninklijke Philips N.V. Patent US12599438B2 for a system and method for determining suitable end point locations for a stent using intraluminal imaging. The system includes processors configured to receive temporal sequences of intraluminal images from an imaging device and identify whether positions along a lumen represent suitable stent end points. The patent contains 19 claims.

Adjustable Marker Reference Device for Surgery (US12599440B2)

USPTO granted Patent US12599440B2 to Point Robotics Medtech Inc. for an adjustable marker reference device used to identify surgical instruments. The patent covers a device with a base, upper cover, connecting rods, markers, and a fixing button mechanism that allows controlled movement and positioning of markers for surgical navigation.

Apparatus and Method for Intra-Cardiac Mapping and Ablation

USPTO granted patent US12599433B2 to Kardium Inc. on April 14, 2026, covering an intra-cardiac mapping system that uses convective cooling effects of blood flow to locate heart chambers for ablation procedures to treat atrial fibrillation. The patent describes a catheter-deployed expandable net or scanning catheter that performs both cardiac mapping and ablation. The patent contains 35 claims with inventors Daniel Gelbart and Samuel Victor Lichtenstein.

Perivascular Nerve Denervation Catheter Patent US12599430B2

USPTO granted patent US12599430B2 to Deepqure Inc. on April 14, 2026. The patent covers a perivascular nerve denervation catheter featuring a shaft with a distal loop configured to curl around tissue and a plurality of electrodes made of two-way shape-memory alloy. The application was filed March 2, 2021, and includes 12 claims.

Uncaging Stent Patent US12599490B2 - Elixir Medical

The USPTO granted Patent US12599490B2 to Elixir Medical Corporation for an uncaging stent technology. The patent covers a stent or luminal prosthesis with circumferential structural elements that provide high strength after deployment and allow for scaffold uncaging and luminal expansion. The patent includes 27 claims and was filed on March 3, 2023.

Male External Catheter with Attachment Interface Configured to Bias Against Penis

USPTO granted Patent US12599495B2 to PUREWICK CORPORATION for a male urine collection device. The patent covers a receptacle for collecting urine with movable flaps configured to bias against the penis, and a clamshell design with two halves connected by a hinge for secure attachment. The filing date was December 23, 2021, with Application No. 17645821 and 17 claims.

Physio Tape With Inductive Heating System

The USPTO granted patent US12599496B1 to inventor Jason Fladoos for an inductive heating system integrated into physio tape. The invention includes plural pockets along the tape length housing removable heating or cooling elements, with at least one being an inductive heating element adapted to receive magnetic energy from a remote inductive heating source. The patent contains 11 claims.

Method of Deploying Intraluminal Device to Cardiac Stomach Region with Endoscopic-Laparoscopic System

USPTO granted patent US12599493B2 to BFKW, LLC for a method of deploying an intraluminal device to the cardiac region of the stomach. The invention involves trans-oral endoscopic deployment of the device with retention against the cardiac region while being fastened laparoscopically from the abdominal cavity with concurrent endoscopic visualization. The patent includes 18 claims covering both the method and the intraluminal system.

Spinal Cage Bone Screw Fixation, Patent US12599489B2, 14th Apr

The USPTO granted Patent US12599489B2 to GBS Commonwealth Co., Ltd. on April 14, 2026, covering a spinal cage fixable through bone screw insertion. The invention includes a cage body with a receiver having multiple screw holes, and a fixture that moves outward during screw insertion and inward after completion to prevent screw separation. The patent contains 8 claims.

Force Redistribution Hindfoot Shoe Insert

The USPTO granted patent US12599494B2 to ROXILLA LLC for a force redistribution hindfoot shoe insert designed to absorb shock and redistribute forces within a user's foot and/or knee. The device includes a hindfoot insert portion with a fascia projection positioned medially between the sides and a lateral projection on the lateral side. The patent contains 22 claims and was filed on April 5, 2023.

Axially Compressible Bare Stent with Overlapping Wires for Aortic Treatment

USPTO granted Patent US12599492B2 to Shanghai Flowdynamics Medical Technology Co., Ltd. for an axially compressible bare stent used in aortic aneurysm and dissection treatment. The stent is formed by interleaving two wires of different diameters (20-150 μm and 150-600 μm) to achieve at least 30% metal coverage with strong radial support. Inventors are Jian Ding and Chenying Fan. The patent includes 16 claims.

Bi-Planar Expandable Spine Cage Patent US12599488B2

USPTO granted patent US12599488B2 to HILO INNOVATIONS, LLC for a bi-planar expandable spinal cage featuring separate sagittal and coronal balance control units. The invention allows independent adjustment of spacing distance and gradient between upper and lower structural bodies. The patent includes 7 claims and covers CPC classifications A61F 2/447 and A61F 2002/443.

Biliary Stent Patent US12599491B2 Granted to BVW Holding AG

USPTO granted Patent US12599491B2 to BVW Holding AG for a biliary stent endoprosthesis featuring a polymeric coating with micropattern surface textures. The patent covers stents with inner/outer surfaces, lumens, and macropattern surface features in both expanded and contracted states. The patent includes 20 claims and names Lukas Bluecher and Michael Milbocker as inventors.

SG LLC Lateral Disc Replacement Implant Patent US12599487B2 Granted

USPTO granted patent US12599487B2 to SG LLC for a lateral disc replacement implant including first and second endplates, a core between the endplates, and an annulus surrounding the core. Inventors: Paul Glazer and Michael J. Milella, Jr. Application filed July 13, 2023.

Electrosurgical Generator Having Extended Measurement Range Patent

USPTO granted patent US12599426B2 to Olympus Winter & Ibe GmbH for an electrosurgical generator with a configurable measurement system. The invention allows switching between different measurement configurations during operation to maintain accuracy across high and low amplitude signals. The patent includes 17 claims.

Bone Fixation Device with Porous Architecture for Bone Ingrowth

USPTO granted Patent US12599418B2 to Paragon Advanced Technologies, Inc. for a bone fixation device featuring a plate portion and a bone wedge portion with porous architecture designed to promote bone ingrowth for fusion and osteosynthesis of bone segments. The patent includes 20 claims and covers the device, manufacturing method, and fixation kit.

Beveled Screw - US12599419B2 - Tyber Medical LLC

USPTO granted Patent US12599419B2 to Tyber Medical LLC on April 14, 2026. The patent covers a beveled screw design featuring a screw head with a bevel, an elongate shaft with a central longitudinal axis, and a tip distal from the head, for implantation into bone or bone fragments. The patent includes 13 claims and covers both the device and associated implantation methods.

Shiga University Surgical Instrument Patent for Coracoid Process and Scapular Neck Movement

The USPTO granted patent US12599420B2 to National University Corporation Shiga University of Medical Science for a surgical instrument designed to facilitate proximity between the coracoid process and scapular neck. The instrument includes a shaft extending in a first direction and an inclined part extending at an angle of 95° to 115° to the first direction, with a notch for screw passage. The patent contains 10 claims and was filed on July 6, 2021.

Sacral Tether Anchor Spinal Implant Patent Granted

The USPTO granted patent US12599421B2 to Empirical Spine, Inc. on April 14, 2026, covering a sacral tether anchor spinal implant system. The patent covers a constraint device with a tether structure and compliance member adapted to couple with a superior spinous process and sacrum, along with an anchor member anchored to the sacrum. Inventors include Todd Alamin, Louis Fielding, Darin Gittings, Hugues Malandain, Anand Parikh, Eller Torres, and Ian Bennett. Medical device manufacturers and competitors in the spinal implant sector should monitor this patent when developing or designing spinal correction and restriction devices. The patent may restrict freedom to operate for similar sacral tether and spinous process constraint systems in the US market.

Perivascular Denervation Catheter Patent Grant to DEEPQURE INC.

The USPTO granted patent US12599425B2 to DEEPQURE INC. on April 14, 2026. The patent covers a perivascular denervation catheter featuring a shaft with a loop disposed near the distal end, configured to curl around tissue and deliver energy for nerve ablation. The loop includes a bendable film, parallel electrodes, and sensors positioned between electrode pairs. The patent contains 13 claims.

Apparatus for Pressing Out Bone Cement, Use and System

USPTO granted patent US12599423B2 to Heraeus Medical GmbH on April 14, 2026. The patent covers an apparatus for pressing out bone cement from a cartridge, featuring a threaded rod with external thread, a handle for rotating the threaded rod, and an adapter unit with internal thread. The outer surface of a thread turn of the external thread is not more than 370 mm2. The patent includes 15 claims and was filed on October 21, 2024.

Cryogenic Catheter Probe for Gastrointestinal Tract Ablation

The USPTO granted patent US12599424B2 to Agil Therapeutics, Inc. on April 14, 2026. The patent covers a cryogenic catheter probe, system, and method for selective ablation of mucosal and submucosal tissue in the gastrointestinal tract. The invention includes a chamber with a central rail, cryogenic fluid delivery channels, and a sprayer configured to release cryogenic spray in treatment zones along the chamber. The patent contains 17 claims.

Smog Suction Structure for Electrosurgical Handpiece

USPTO granted Patent US12599427B2 to inventor In-Sang Choi for a smog suction structure designed for electrosurgical handpieces. The invention efficiently removes surgical smog that obstructs the operating surgeon's view and poses health hazards. The patent, filed on December 3, 2020, includes 7 claims and is classified under CPC codes related to electrosurgical instruments and suction devices.

Energy Treatment Tool and Treatment System - US12599428B2

USPTO granted Patent US12599428B2 to Olympus Corporation on April 14, 2026. The patent covers an energy treatment tool with a grip, lever mechanism, electric switch, and rotatable driver for switching between contacting and noncontacting states. The invention, filed July 20, 2021 (Application No. 17380868), contains 19 claims under CPC classifications A61B 18/1447 and related A61B subclasses.

Electronic Prior Authorization Requirements for Medicare Advantage Medicaid CHIP QHP Issuers

CMS published a proposed rule (CMS-0062-P) requiring Medicare Advantage organizations, state Medicaid and CHIP fee-for-service programs, Medicaid managed care plans, CHIP managed care entities, and Qualified Health Plan issuers on the Federally-facilitated Exchanges to implement electronic prior authorization for drugs and extend existing interoperability requirements to drugs. The rule would also require impacted payers to report API endpoints to CMS, adopt HL7 FHIR standards as HIPAA transaction standards, and would establish a definition for "failure to report" enabling civil monetary penalties for applicable manufacturers or GPOs that fail to grant CMS timely access for audits. Comments are due June 15, 2026.

Medicare HCPCS Level II Public Meeting

CMS announces the first biannual 2026 HCPCS Level II public meeting to discuss preliminary coding, Medicare benefit category, and payment determinations for new non-drug and non-biological items and services. The primary meeting is scheduled for June 1, 2026 in Baltimore, MD, with an overflow virtual session on June 2, 2026. Speaker registration closes May 18, 2026, and written comments are due June 3, 2026.

Merit Medical Recalls 16F Dual-Valved Splittable Sheath Introducer

Merit Medical is recalling the 16F Dual-Valved Splittable Sheath Introducer, a component used in several dialysis catheter kits, due to a design defect where the sheath introducer may not split as intended. The FDA has classified this as a Class I recall, the most serious type. Healthcare providers are advised to immediately stop using, apply recall stickers to, and destroy affected devices. Two serious injuries have been reported as of February 23, 2026, with no deaths associated with this issue.

Treasury Proposes Whistleblower Rewards for Reporting Healthcare Fraud

FinCEN released a proposed rule on March 30, 2026, to establish a new whistleblower reward program targeting financial crimes including fraud against government healthcare plans. Qualifying whistleblowers may receive 10 to 30 percent of funds recovered when enforcement penalties exceed $1 million. The program excludes certain employees involved in compliance, audit, or internal reporting processes from bounty eligibility unless 120 days pass without corrective action.

Virginia Senate Bill 170 and House Bill 627 Restrict Noncompete Agreements

Virginia has enacted SB 170 and HB 627, landmark legislation restricting covenants not to compete. SB 170 requires employers to provide severance benefits for noncompetes to be enforceable when terminating employees without cause, with civil penalties of $10,000 per violation. HB 627 categorically prohibits noncompetes with health care professionals licensed by the Board of Medicine, Nursing, Counseling, Optometry, Psychology, or Social Work, with an exception only for sale-of-business scenarios. The laws apply to all agreements entered, amended, or renewed on or after July 1, 2026.

EPA Draft CCL 6 Identifies Microplastics and Pharmaceuticals as Priority Drinking Water Contaminants

The EPA published its draft Sixth Contaminant Candidate List (CCL 6) on April 2, 2026, identifying microplastics and pharmaceuticals as priority contaminant groups for potential future drinking water regulation under the Safe Drinking Water Act. The draft also includes PFAS, disinfection byproducts, 75 individual chemicals, and nine microbes. EPA announced human health benchmarks for 374 pharmaceuticals. The draft CCL 6 is a procedural screening step that does not itself establish enforceable standards or require immediate action by water systems or industry.

Single-Domain Antibodies That Bind ROR1

USPTO granted Patent US12600801B2 to Fred Hutchinson Cancer Center for single-domain antibodies binding receptor tyrosine kinase ROR1. The patent covers anti-cancer therapeutics, antibody-drug conjugates, multi-domain binding molecules, and cancer imaging/diagnostic agents. The patent contains 20 claims with inventors Jason Price, Colin E. Correnti, and James M. Olson.

CD38 Antibody Variant Improves Manufacturing Yield

USPTO granted patent US12600790B2 to Vivasor, Inc. covering a variant anti-CD38 IgG antibody with improved manufacturing yield and a mutated light chain that reduces cleavage heterogeneity. The patent contains 19 claims and is classified under C07K 16/2878 and related CPC codes.

IGF-1R Antibodies With Extended Half-Lives for Thyroid Eye Disease Treatment

USPTO granted US Patent US12600788B2 to Viridian Therapeutics, Inc. covering antibodies and compositions targeting Insulin-Like Growth Factor-1 Receptor (IGF-1R) with extended half-lives for treating thyroid eye disease. The patent contains 18 claims and names six inventors including Vahe Bedian, Peter Harwin, and Jonathan Violin.

5T4 Binding Polypeptides for Cancer Therapy

USPTO granted patent US12600794B2 to Abdera Therapeutics for 5T4 binding polypeptides useful for cancer therapy. The 36 claims cover polypeptides conjugated to chelating agents or radionuclide complexes. The patent protects compositions and methods for treating 5T4-expressing cancers.

Anti-IgG Nanobodies Patent Granted to Max-Planck

USPTO granted patent US12600799B2 to Max-Planck-Gesellschaft on April 14, 2026 for novel anti-IgG nanobodies directed against rabbit or mouse IgG. The patent contains 11 claims classified under CPC C07K 16/42. The invention also covers methods for producing and using said nanobodies.

DONGBANG MEDICAL Rhinoplasty Suture Patent Granted

USPTO granted patent US12599478B2 to DONGBANG MEDICAL CO., LTD. for a lifting suture for rhinoplasty and manufacturing method. The patent covers a device with cogs formed in first and second regions connected by a pressed connecting region. Application 18382060 was filed October 20, 2023, with 5 claims.

Transcatheter Mitral Valve Regurgitation Coaptation Device with Secondary Anchors

USPTO granted Patent US12599482B2 to Polares Medical Inc. for a transcatheter mitral valve regurgitation coaptation device with secondary anchors. The patent covers a coaptation assistance element, delivery catheter, and implantation method with 20 claims.

US12599483B2 Boney Structure Joining Patent Grant

USPTO granted patent US12599483B2 to Randall F. Lee for systems and methods to join boney structures. The invention uses at least one non-threaded anchor and an implant with apertures, where the anchor head interacts with the implant aperture to cause transverse movement for compression or distraction of coupled boney structures. The patent has 7 claims.

US12599486B2 - Glenoid Implant Pin Placement Instrument with Patient Specific Instrumentation

USPTO granted patent US12599486B2 for a pin placement instrument used in glenoid implant surgery. The instrument features an anatomical interface with a hook-like portion for receiving bone in a planned position, a drill guide with lateral-opening slots, and a removably placeable bushing for pin placement. The patent was filed August 3, 2022, under application number 17880302, with 7 claims.

Edwards Lifesciences Percutaneous Mitral Valve Replacement Patent B2

The USPTO granted patent US12599480B2 to Edwards Lifesciences Corporation for a percutaneous mitral valve replacement device. The prosthetic heart valve includes an outer frame with atrial flange, an inner frame, and a valve structure with leaflets, designed to match the patient's native mitral valve anatomy. The patent contains 10 claims and was filed on November 15, 2023.

Heart Valve Crown Piece with Leaflets, Top Cuff, and Bottom Cuff Patent

USPTO granted Patent US12599479B2 to Venus Medtech (Hangzhou), Inc. for a heart valve comprising a crown piece interconnected to leaflets, a top cuff, and a bottom cuff. The invention includes ring-shaped crown piece, top cuff, and bottom cuff components designed for interconnection with medical implant frames. The patent contains 16 claims and covers the structural configuration of transcatheter heart valve assemblies.

Polishing Device for Orthopedic Devices Patent Granted

USPTO granted Patent US12599484B1 to Spartan Felt Company, Inc. on April 14, 2026. The patent covers a polishing device for orthopedic implants, including acetabular cups. The device features a compressible polishing head with rounded surfaces for polishing concave surfaces, made from impregnated felt materials. The patent contains 8 claims and was filed on July 9, 2021.

Systems and Methods for Prosthetic Heart Valve Delivery

USPTO granted Patent US12599481B2 to 4C Medical Technologies, Inc. for delivery systems and methods for implanting prosthetic heart valves. The patent covers technology for delivering self-expanding prosthetic mitral valve devices to the left atrium without engagement of the left ventricle or native mitral valve leaflets. The patent contains 16 claims and was filed on November 8, 2023.

Artificial Eye Lens with Cavity Design for Reduced Incision Implantation - US12599477B2

USPTO granted patent US12599477B2 to Carl Zeiss Meditec AG for an artificial eye lens with front and rear lens elements connected by an intermediate element forming a cavity with an opening for liquid flow. The design allows reduction of the access incision necessary for implantation. The patent includes 15 claims and covers methods for production and implantation of the lens.

Bone Anchoring Device with Receiving Part for Rod Coupling

USPTO granted patent US12599414B2 to Biedermann Technologies GmbH & Co. KG for a bone anchoring device receiving part. The device includes a receiving body with a rod-receiving channel and accommodation space, plus a pressure element with a flexible portion for clamping a bone anchoring element head. The pressure element moves along the receiving part's longitudinal axis from an inserting position through pre-locking to a final locking position.

Patella Bone Plate System

The USPTO granted Patent US12599417B2 to Smith & Nephew, Inc. on April 14, 2026, covering patella bone plate systems for surgical reconstruction. The patent claims a contoured body with arms, variable angle holes, locking and fixation holes, slots, and a hook design extending around the patella apex. The 19 claims establish enforceable intellectual property rights for the assignee.

NuVasive Adjustable Implant Patent US12599416B2 Granted

USPTO granted patent US12599416B2 to NuVasive Specialized Orthopedics, Inc. on April 14, 2026. The patent covers an adjustable implant including a housing, a first adjustable member positioned within the housing and moveable relative to the housing, and a first actuation assembly configured to move the first adjustable member relative to the housing. The patent contains 18 claims and is classified under CPC A61B 17/7016 and related surgical device categories.