Transmission mode-photoacoustic tomography of the human brain through an acoustic window

The USPTO granted Patent US12593986B2 to the California Institute of Technology covering photoacoustic imaging techniques for transmission mode tomography of the human brain through an acoustic window in the skull. The patent lists inventors Yang Zhang, Sri Sai Narasimha KS Dhara Venkata, and Lihong Wang, with 27 claims. This patent grant establishes enforceable intellectual property rights for diffuse light delivery and acoustic wave detection in brain imaging applications.

Quorum Sensing Compositions and Methods for Microbial Community Modulation

USPTO granted patent US12594307B2 to The Regents of the University of California for quorum sensing compositions and methods for modulating bacterial quorum sensing. The patent covers engineered bacterial strains with multiple activator polypeptide-encoding sequences and methods for tunable dynamics in microbial communities. Inventors include Jeff Hasty, Arianna Miano, and Michael Julius Liao, with applications spanning synthetic biology and therapeutic development.

Single domain antibodies for cancer therapy, Institut Curie

USPTO granted Patent US12594302B2 to Institut Curie covering fully humanized anti-FGFR4 single domain antibodies (sdAbs), functionalized drug nanocarriers, and compositions for cancer therapy. The patent includes 24 claims and covers nucleic acids, vectors, host cells, and immune cells comprising said sdAbs. The invention relates to FGFR4-targeted therapies for treating cancer.

Bispecific CAR Targeting CD19 and CD20 for Cancer Treatment

USPTO granted Patent US12594321B2 to Novartis AG for a bispecific chimeric antigen receptor (CAR) targeting CD19 and CD20 for cancer treatment. The patent covers CAR proteins, encoding nucleic acids, vectors, and methods for treating diseases associated with CD20 or CD22 expression using modified T or NK cells. The patent includes 18 claims and lists 6 inventors.

Temperature-Optimized Bacillus Strains Patent Grant

The USPTO granted patent US12593849B2 to Chr. Hansen A/S on April 7, 2026, covering new strains of Bacillus paralicheniformis with improved growth rates and plant growth promoting properties. The patent names six inventors including Patricia Dominguez Cuevas and Lars Moelbak, with 21 claims. Filing date was August 28, 2020, under application number 17638152.

Virus-like Particles Patent Granted to University of Denver

The USPTO granted Patent US12594329B2 to the University of Denver on April 7, 2026. The patent covers virus-like particles, compositions, antibody detection tests using virus-like particles, and methods of producing non-replicating virus-like particles from modified viral genomes. Schuyler B. van Engelenburg is the sole inventor of the 9-claim patent.

CD8-specific capture agents, compositions, and methods of using and making

The USPTO granted Regeneron Pharmaceuticals patent US12594350B2 covering stable peptide-based CD8 capture agents for use as detection agents. The patent was issued April 7, 2026, naming Regeneron Pharmaceuticals, Inc. as assignee and Heather Dawn Agnew and Bert Tsunyin Lai as inventors. The application, filed April 4, 2017 (Application No. 15478596), contains 13 claims.

HIV Oral Drug Composition Patent

The USPTO granted Patent US12594244B2 to Gilead Sciences, Inc. covering a solid oral dosage form combining tenofovir alafenamide, emtricitabine, and a compound of Formula I for HIV treatment. The patent contains 29 claims and was granted on April 7, 2026, with a filing date of September 29, 2025.

Topiramate oral liquid suspension patent granted

USPTO granted patent US12594241B2 to inventors Paul Sudhakar and Scott Boyer for an oral liquid suspension formulation containing topiramate (Application No. 18462651). The patent contains 29 claims covering the composition and methods of medical treatment using the formulation. Generic and branded pharmaceutical manufacturers should assess this patent for potential freedom-to-operate implications.

Exosome Production Method for Cancer Therapeutic Delivery

USPTO granted patent US12594344B2 to China Medical University for a large-scale exosome production method using cyclic tensile bioreactors. The patent covers exosomes with anti-HLA-G protein configured as delivery vehicles for cancer therapeutic agents. The grant includes 10 claims and applies to A61P 35/00 (antineoplastic agents) and related CPC classifications.