Real-time facial restoration and relighting in videos using facial enhancement neural networks

The USPTO granted Microsoft Technology Licensing, LLC patent US12597096B2 covering an image restoration system that enhances low-quality video images in real-time using neural networks. The technology combines autoencoder models with distortion classifiers to dynamically re-light and restore faces captured under low-light conditions. The patent includes 20 claims.

Macrocyclic ULK1/2 inhibitors for cancer treatment

The USPTO has granted patent US12594277B2 to the Sal k Institute for Biological Studies covering macrocyclic ULK1/2 inhibitors and their therapeutic applications. The patent includes 8 claims directed to compounds and methods for treating cancer using ULK-mediated diseases. The patent expires April 2026 with a February 2021 filing date.

Capsid inhibitors for the treatment of HIV

The USPTO granted Patent US12594267B2 to Gilead Sciences, Inc. covering capsid inhibitor compounds of Formula (Ia) and (Ib) for treating HIV infections in heavily treatment-experienced patients with multidrug resistant HIV. The patent includes 13 claims and lists inventors Anna Chiu, Charles William Rowe, and Scott P. Sellers.

Hyaluronic acid pluronic hydrogel for articular cartilage treatment

USPTO granted Patent US12594297B2 to Medicrinia, Co., Ltd. on April 7, 2026, covering a hydrogel composition of hyaluronic acid and pluronic for preventing or treating articular and cartilage injury. The patent has 9 claims, CPC classifications A61K 31/728, A61K 9/06, A61K 47/36, A61P 19/02, and was filed on August 3, 2020.

Method for enhancing pharmacokinetics using P450 inhibitors with piperidine carboxylate

USPTO granted Takeda Pharmaceutical patent US12594269B2 covering compositions comprising methyl 3-((methylsulfonyl)amino)-2-(((4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate or a salt thereof combined with cytochrome P450 inhibitors to enhance pharmacokinetics and plasma concentration. The patent, containing 18 claims, is assigned to Takeda Pharmaceutical Company Limited with inventors including Mark Rogge, Hélène Faessel, Hong Lu, and others.

Methods of treating Fabry disease in patients having a mutation in the GLA gene

USPTO granted Amicus Therapeutics Patent No. US12594268B2 covering methods of treating Fabry disease using pharmacological chaperones for α-galactosidase A in patients with GLA gene mutations. The patent includes 9 claims and was filed on January 16, 2019. This IP protection grants Amicus Therapeutics exclusive rights to these therapeutic methods for the rare genetic disorder.

IP and IP analogs dosage regimens for treatment of ectopic calcifications

The USPTO granted patent US12594290B2 to Sanifit Therapeutics S.A. on April 7, 2026, covering compositions and dosage regimens of inositol phosphate compounds for treating ectopic calcifications, particularly calciphylaxis. The patent specifically claims daily doses of 6-9 mg/kg of myo-inositol hexaphosphate administered three times weekly for 1-8 months.

Medical stroboscope endoscopy system with rolling shutter image sensor

USPTO granted patent US12593970B2 to KARL STORZ Imaging, Inc. for a medical stroboscope endoscopy system utilizing rolling shutter image sensors with strobe light pulsing. The patent covers methods and devices for combining subset image data from adjacent rolling-shutter frames into enhanced video frames for endoscopic imaging applications.

CoMind Technologies iNIRS System Patent Granted

USPTO granted Patent US12593983B2 to CoMind Technologies Limited for an interferometric near infrared spectroscopy (iNIRS) system. The patent covers a light emitting arrangement with wavelength swept emission, a light detecting arrangement with an interferometric optical detector, and multiple optical channel paths for delivering sample and reference light. The patent contains 20 claims and is classified under CPC codes including A61B 5/0075 and G16H 40/63.

Medtronic Patent - Atrial Tachycardia Detection Based on Cardiac Rhythm Regularity

The USPTO granted Medtronic patent US12594019B2 covering systems and methods for detecting atrial tachycardia (AT) by analyzing cardiac rhythm regularity. The patent discloses techniques that apply different AT detection criteria depending on whether heart beat intervals are determined to be regular or irregular, enabling more accurate identification of AT episodes.