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University of Pittsburgh Heat Shock Protein Modulator Patent for Huntington Disease

USPTO granted patent US12600705B2 to University of Pittsburgh for thiadiazine compounds as heat shock protein modulators. The patent covers therapeutic applications for Huntington disease, other neurodegenerative disorders, and cancer. The patent includes 13 claims.

Hoffmann-La Roche Granted Amino-Pyrimidine Amide Patent US12600712B2

USPTO granted Patent US12600712B2 to Hoffmann-La Roche Inc. on April 14, 2026, covering amino-pyrimidine amide compounds with general formula (I) and methods of using such compounds. The patent includes 11 claims and CPC classifications C07D 403/06 and C07D 491/107 in organic chemistry. The filing date was December 7, 2022, with Application No. 18062644.

Bioniz Therapeutics - Peptide Cytokine Inhibitors Patent Grant US12600757B2

The USPTO granted Patent US12600757B2 to Bioniz Therapeutics, Inc. on April 14, 2026. The patent covers stable peptide antagonists targeting the gamma-c (γc) subunit binding site to inhibit activity of γc-cytokine family members. The 16 claims apply to therapeutic and cosmetic agents as well as research tools for treating diseases associated with γc-family cytokines.

Anti-TDP-43 Binding Molecules and Uses Thereof

The USPTO granted Patent No. US12600766B2 to AC Immune SA covering anti-TDP-43 specific binding molecules, including antibodies and antigen-binding fragments, for diagnosing, preventing, and treating diseases associated with TDP-43 aggregates. The patent lists 15 claims and names Tamara Seredenina, Tamar Magdalena Ziehm, and Tariq Afroz as inventors. The filing date was May 22, 2020, under Application No. 17613444.

IBM Granted Patent for Antigen-Binding Proteins Targeting SARS-CoV-2 Variants

USPTO granted IBM (International Business Machines Corporation) Patent US12600764B2 for antigen-binding proteins capable of binding to SARS-CoV-2 coronavirus variants. The patent covers compositions comprising heavy polypeptide chain variable regions with specific amino acid substitutions (R50, I54, L55 positions) that enhance binding to CoV variants. The patent includes 14 claims and was filed on August 27, 2021.

ASKGENE Pharma Granted Patent for Masked Cytokines

USPTO granted Patent No. US12600762B2 to ASKGENE PHARMA, INC. on April 14, 2026. The patent covers masked cytokines (prodrugs) and methods of use for stimulating the immune system, treating cancer, autoimmune diseases, or infectious diseases. The patent contains 19 claims and was filed on January 11, 2021 under Application No. 17787741.

ENZENE BIOSCIENCES - GLP-1 Receptor Agonist Preparation Process Patent

The USPTO granted patent US12600759B2 to Enzene Biosciences Limited covering processes for preparing glucagon-like peptide-1 (GLP-1) receptor agonists and their analogs. The patent specifically encompasses processes for preparing liraglutide, D-liraglutide, semaglutide, and D-semaglutide in substantially pure form. The application (17440127), filed on March 19, 2020, contains 4 claims and covers both solid and solution phase preparation methods.

Modified S2 Subunit Coronavirus Spike Protein Patent US12600751B2

The USPTO granted patent US12600751B2 to inventors Annika Kraemer-Kuehl and Thomas Min Stephan for a modified S2 subunit of coronavirus spike protein featuring a mutation at amino acid position 865. The patent covers a recombinant avian coronavirus spike protein or fragment thereof, along with an immunogenic composition containing the modified spike protein. The patent includes 22 claims with filing date May 6, 2020.

Native Chemical Ligation Flow Synthesis - University of Sydney

The USPTO granted Patent US12600746B2 to the University of Sydney covering synthetic methods using native chemical ligation in flow for synthesizing polypeptides. The patent, invented by Richard J. Payne and Tim Chisholm, includes 27 claims and covers selective desulfurization or deselenization of amide-containing compounds with thiol, disulfide, selenol, or diselenide functional groups. The patent application was filed on May 22, 2019, under application number 17057069.

Affinity Chromatography of Immunoglobulins Using Pre-capture Flocculation

USPTO granted patent US12600748B2 to RICHTER GEDEON NYRT on April 14, 2026. The patent covers methods for purifying immunoglobulins from cell culture harvest using pre-capture cleaning steps including flocculation and filtration before affinity chromatography. The invention improves eluted immunoglobulin quality, reduces precipitation during chromatography, and extends the lifetime of affinity resin used in large-scale immunoglobulin production.