Affinity Chromatography of Immunoglobulins Using Pre-capture Flocculation
Summary
USPTO granted patent US12600748B2 to RICHTER GEDEON NYRT on April 14, 2026. The patent covers methods for purifying immunoglobulins from cell culture harvest using pre-capture cleaning steps including flocculation and filtration before affinity chromatography. The invention improves eluted immunoglobulin quality, reduces precipitation during chromatography, and extends the lifetime of affinity resin used in large-scale immunoglobulin production.
What changed
USPTO granted patent US12600748B2 to pharmaceutical company RICHTER GEDEON NYRT for immunoglobulin purification methods. The patent claims sequential processes combining flocculation, filtration, affinity chromatography capture, and downstream polishing chromatography to yield high-purity immunoglobulins from cell culture. Patent confers exclusive rights to the assignee for the claimed methods through the patent term.
For pharmaceutical manufacturers and biotechnology companies engaged in antibody or immunoglobulin production, this patent may affect process development decisions or require licensing considerations for similar purification methods. Parties developing or using comparable pre-capture cleaning steps in immunoglobulin purification workflows should assess potential patent infringement exposure.
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Apr 14, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Affinity chromatography of immunoglobulins by using pre-capture flocculation
Grant US12600748B2 Kind: B2 Apr 14, 2026
Assignee
RICHTER GEDEON NYRT.
Inventors
Zsuzsanna Keszey, Zoltán Sütö
Abstract
The present invention relates to new methods for the purification of immunoglobulins from cell culture harvest. These methods are characterized by cleaning steps preceding an initial capture chromatography step. Preferably, the initial capture chromatography is an affinity chromatography and the pre-capture cleaning effect is obtained by flocculation and filtration. By using such pre-capture cleaning steps, an improved quality of the eluted immunoglobulin from the capture matrix is achieved. Furthermore, the enhanced clarification of the cell culture liquid results in reduced precipitations during affinity chromatography and thus increases the lifetimes of the expensive affinity resin. This is an important improvement for immunoglobulin purification in large scale production. The present invention further relates to sequential polishing chromatographies and filtration steps downstream to the capture chromatography, yielding immunoglobulins of high purity.
CPC Classifications
C07K 1/22 C07K 1/18 C07K 1/34 C07K 1/36
Filing Date
2020-03-25
Application No.
17601197
Claims
26
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