Native Chemical Ligation Flow Synthesis - University of Sydney

The USPTO granted Patent US12600746B2 to the University of Sydney for methods of synthesizing amide-containing compounds, particularly polypeptides, via native chemical ligation in flow. The patent covers selective desulfurization or deselenization processes for compounds comprising thiol, disulfide, selenol, or diselenide functional groups. The invention is classified under multiple CPC codes including C07K 1/1075, C07K 7/06, and C07C 323/36.

For affected parties in pharmaceutical manufacturing and biotechnology research, this patent establishes intellectual property rights for native chemical ligation flow synthesis methods at the University of Sydney. Parties developing similar peptide synthesis technologies should review the patent claims to assess potential licensing needs or design-around considerations.