Neural Mobilization vs Cervical Neuromodulation in Diabetic Peripheral Neuropathy: Randomized Pilot Trial, 75 Participants
Summary
NIH registered a three-arm, assessor-blinded randomized controlled pilot feasibility trial (NCT07537270) comparing Manual Neural Mobilization and Cervical Neuromodulatory Intervention against standard care in 75 participants with diabetic peripheral neuropathy over 12 weeks. The primary endpoints are recruitment rates, adherence, and safety; secondary endpoints include HbA1c, fasting blood glucose, and pain intensity. The trial is registered in ClinicalTrials.gov as a pilot feasibility study ahead of a potential full-scale RCT.
What changed
NIH added a new clinical trial registration (NCT07537270) for a pilot feasibility RCT evaluating two manual therapy techniques—Manual Neural Mobilization and Cervical Neuromodulatory Intervention—in individuals with diabetic peripheral neuropathy. Seventy-five participants are randomized across three arms for a 12-week intervention period. The primary outcomes are feasibility metrics (recruitment rate, adherence, safety), while secondary outcomes include metabolic markers (HbA1c, fasting blood glucose) and pain intensity.\n\nHealthcare providers and clinical investigators involved in diabetes or neuropathy management should note this trial as an emerging evidence source on non-pharmacological adjunctive therapies for DPN. The trial's focus on glycemic outcomes may inform future treatment protocols if the interventions demonstrate feasibility and signal efficacy. This registry entry does not impose compliance obligations but reflects active clinical research in the diabetes care space.
Archived snapshot
Apr 17, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Neural Mobilization vs Cervical Neuromodulation in DPN
N/A NCT07537270 Kind: NA Apr 17, 2026
Abstract
This study is a three-arm, assessor-blinded, randomized controlled pilot feasibility trial. The primary goal is to evaluate the feasibility and acceptability of conducting a full-scale randomized controlled trial (RCT) comparing two manual therapy techniques: Manual Neural Mobilization (MNM) and Cervical Neuromodulatory Intervention (CNI) in individuals with Diabetic Peripheral Neuropathy (DPN).
While glycemic control is a central part of managing type 2 diabetes, this study explores whether non-pharmacological manual therapies can serve as adjunctive interventions to improve metabolic outcomes. A total of 75 participants were assigned to either MNM, CNI, or standard care for 12 weeks. The study focuses on recruitment rates, adherence, and safety, while also exploring secondary outcomes like blood glucose levels (HbA1c, FBG) and pain intensity.
Conditions: Diabetic Peripheral Neuropathy Type 2
Interventions: Manual Neural Mobilization, Cervical Neuromodulatory Intervention, Standard Care
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