Randomized Trial Comparing PTCD Catheter Removal vs Retention After Pancreaticoduodenectomy in Obstructive Jaundice
Summary
NIH registered a multicenter prospective randomized controlled trial (NCT07532759) comparing intraoperative PTCD catheter removal versus retention during pancreaticoduodenectomy in patients with obstructive jaundice. The trial will enroll participants with pancreatic head cancer, periampullary neoplasms, and biliary tract neoplasms to evaluate postoperative complications including bile leak and severe morbidity within 90 days.
What changed
NIH registered a new prospective randomized controlled trial on ClinicalTrials.gov (NCT07532759) comparing two intraoperative strategies for managing PTCD catheters during pancreaticoduodenectomy: removal versus retention. The study focuses on patients with obstructive jaundice from pancreatic head cancer, periampullary neoplasms, and biliary tract neoplasms.
For affected parties, the trial aims to generate evidence guiding surgical decision-making regarding PTCD catheter management. Healthcare providers and clinical investigators involved in pancreatic surgery may benefit from monitoring trial outcomes, which will assess major complications (bile leak, severe morbidity), recovery metrics, hospital length of stay, and quality of recovery over 90 days post-surgery.
Archived snapshot
Apr 16, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice
N/A NCT07532759 Kind: NA Apr 16, 2026
Abstract
Pancreaticoduodenectomy (PD) is a complex surgical procedure commonly performed for tumors of the pancreatic head and periampullary region. Many patients present with obstructive jaundice and undergo preoperative percutaneous transhepatic cholangial drainage (PTCD) to relieve biliary obstruction. However, there is currently no consensus on whether the PTCD catheter should be removed or retained during surgery.
This multicenter, prospective randomized controlled trial aims to compare two intraoperative strategies: removal versus retention of the PTCD catheter during PD. Participants will be randomly assigned to either group. The study will evaluate whether these different approaches influence postoperative outcomes, particularly major complications such as bile leak and severe postoperative morbidity within 90 days after surgery.
In addition to complications, the study will assess recovery after surgery, including return of gastrointestinal function, length of hospital stay, and quality of recovery, as well as laboratory indicators of liver function and inflammation.
The results of this study are expected to provide evidence to guide surgical decision-making regarding PTCD management during PD and to improve patient outcomes.
Conditions: Obstructive Jaundice, Pancreatic Head Cancer, Periampullary Neoplasms, Biliary Tract Neoplasms
Interventions: PTCD Catheter Removal, PTCD Catheter Retention
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