EIT Pilot Study Tests Perfusion and Ventilation Distribution in Children
ClinicalTrials.gov Studies
Summary
The NIH has registered a new pilot study (NCT07532811) on ClinicalTrials.gov evaluating the feasibility of assessing pulmonary perfusion in children using electrical impedance tomography (EIT) with a weight-adjusted hypertonic saline bolus. The study addresses a gap in pediatric protocols, as existing adult perfusion assessment methods using 10 mL of 7.5-10% NaCl are unsuitable for small children. The single-center study targets children with acute respiratory failure.
What changed
This entry registers a new pilot study on ClinicalTrials.gov titled 'Evaluation of Perfusion and Ventilation Distribution in Children.' The study will use electrical impedance tomography following injection of sodium chloride or sodium bicarbonate to assess regional pulmonary perfusion and ventilation/perfusion ratio in children with acute respiratory failure. Current adult protocols require 10 mL of hypertonic saline, which is inappropriate for pediatric patients. The study seeks to establish a weight-adjusted bolus protocol.
Affected parties include clinical investigators conducting pediatric respiratory research and healthcare providers treating children with acute respiratory failure. Researchers should note this study represents a novel protocol development effort addressing an identified gap in pediatric pulmonary assessment methodologies.
Archived snapshot
Apr 17, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.
N/A NCT07532811 Kind: NA Apr 16, 2026
Abstract
Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution. Following the injection of a hypertonic saline bolus, EIT can also assess regional pulmonary perfusion distribution, allowing evaluation of the ventilation/perfusion (V/Q) ratio.
In adults, protocols for assessing perfusion distribution require the injection of 10 mL of a 7.5% or 10% NaCl solution or sodium bicarbonate over a few seconds. Studies have reported good hemodynamic tolerance, adequate image quality, and no significant changes in serum sodium levels. However, this volume and sodium load are not appropriate for small children.
To date, no pediatric protocol exists for assessing pulmonary perfusion distribution and the ventilation/perfusion ratio using EIT. It is therefore proposed to conduct a pilot study to evaluate the feasibility of assessing pulmonary perfusion by EIT using a weight-adjusted bolus of hypertonic saline (NaCl or sodium bicarbonate).
Conditions: Acute Respiratory Failure
Interventions: Evaluation of perfusion with Electrical impedance tomography using sodium chloride or sodium bicarbonate
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