0.01% and 0.025% Atropine Eye Drops Combined With Auricular Acupoint Stimulation for Myopia Control in Children
Summary
NIH has registered a randomized, double-blind, placebo-controlled pilot trial (NCT07537166) evaluating low-dose atropine (0.01%, 0.025%) combined with auricular acupoint stimulation for myopia control in 420 children aged 6-12. Participants will be divided into six groups receiving different treatments or placebo over a 12-week follow-up period. The study aims to determine synergistic effects of combined therapy and establish safer treatment options for myopia, addressing corneal toxicity concerns associated with higher 0.05% atropine concentrations.
What changed
NIH registered a clinical trial (NCT07537166) on ClinicalTrials.gov involving low-dose atropine eye drops at two concentrations combined with auricular acupoint stimulation for myopia control in children aged 6-12. The pilot study will enroll 420 participants across six treatment arms and monitor corneal endothelial changes over 12 weeks.
For clinical investigators and trial sponsors, this registry entry indicates a planned study addressing safety concerns with higher-dose atropine (0.05%) by evaluating lower concentrations. The study may influence future pediatric ophthalmology research protocols and potential treatment guidelines for myopia management.
Archived snapshot
Apr 17, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
0.01% and 0.025% Atropine Eye Drops Combined Auricular Acupoint Stimulation on Myopia Control and Corneal Endothelium Change
N/A NCT07537166 Kind: NA Apr 17, 2026
Abstract
This randomized, double-blind, placebo-controlled pilot trial evaluates the efficacy and safety of low-dose atropine (0.01%, 0.025%) combined with auricular acupoint stimulation for myopia control in children. While 0.05% atropine is effective, it may pose corneal toxicity risks, highlighting the need for safer alternatives. Auricular acupuncture has shown potential benefits in systematic reviews.
A total of 420 children aged 6-12 will be randomized into six groups receiving different treatments or placebo, with a 12-week follow-up. The auricular Eye Point will be stimulated, and comprehensive visual and ocular assessments will be conducted, including corneal endothelial monitoring.
This study aims to determine the synergistic effect of combined therapy and provide a safer treatment option, laying the foundation for future large-scale trials.
Conditions: Acupressure
Interventions: Auricular acupoint stimulation, 0.01% concentration atropine drops, 0.025% atropine eye drops, Artificial Tears (AT)
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