GEN-AL-RF Trial: Genicular Nerve RF Ablation vs Alcohol Neurolysis for Knee Osteoarthritis Pain
Summary
The NIH ClinicalTrials.gov registry has published NCT07537335, a randomized controlled trial comparing genicular nerve radiofrequency ablation to neurolytic alcohol injection for managing chronic knee pain in osteoarthritis patients. The 6-month study will assess pain intensity using the Numeric Rating Scale, physical function via WOMAC scores, and quality of life through SF-12 metrics. Results aim to provide comparative effectiveness evidence for these interventional pain management techniques.
What changed
This entry registers a new randomized controlled trial (NCT07537335) on ClinicalTrials.gov comparing genicular nerve radiofrequency ablation versus neurolytic alcohol injection for knee osteoarthritis pain management. The study will enroll patients with knee osteoarthritis, randomizing them to receive either intervention, with outcomes assessed at baseline and 1, 3, and 6 months.
For healthcare providers and clinical investigators, this represents a forthcoming evidence source regarding comparative effectiveness of two interventional pain management approaches. The trial does not impose any compliance obligations but may inform future clinical practice guidelines and payer coverage decisions for genicular nerve ablation procedures.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Knee Osteoartritis Genicular Nerve RF Ablation vs Alcohol Neurolysis
N/A NCT07537335 Kind: NA Apr 17, 2026
Abstract
The GEN-AL-RF study is a randomized controlled trial designed to compare the clinical efficacy of two interventional techniques for managing chronic knee pain due to osteoarthritis. The study focuses on genicular nerve radiofrequency (RF) ablation versus neurolytic alcohol injection for pain blockade.
Patients diagnosed with knee osteoarthritis are randomly assigned to either the RF ablation group or the neurolytic alcohol group. The primary objective is to evaluate the superiority and duration of analgesic effects between these two methods. Clinical outcomes are assessed at baseline and at 1, 3, and 6 months post-procedure using the Numeric Rating Scale (NRS) for pain intensity, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for physical function, and the Short Form-12 (SF-12) for health-related quality of life.
The results of this study aim to provide high-quality evidence regarding the comparative effectiveness and long-term outcomes of genicular nerve RF and alcohol neurolysis in the clinical management of chronic knee osteoarthritis pain.
Conditions: Knee Osteoarthristis, Radiofrequency Ablation, NEUROLYSIS
Interventions: genicular nerve block
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