Phase 4 Randomized Trial of Indomethacin and Paracetamol for Pain Management During IVF Oocyte Retrieval

NIH registered a new Phase 4 clinical trial on ClinicalTrials.gov (NCT07536425) investigating the efficacy of preoperative analgesics for pain management during oocyte retrieval. The randomized controlled trial will evaluate Indomethacin (100 mg per rectum) combined with Paracetamol/Acamol (1,000 mg intravenously) versus standard care in women undergoing IVF or ICSI procedures. Conditions studied include Pain and Oocyte Retrieval.

For affected parties, this trial registration informs healthcare providers, fertility clinics, pharmaceutical manufacturers, and clinical investigators about an upcoming study that may generate evidence for improved pain management protocols in reproductive medicine. Trial sponsors and clinical investigators should ensure compliance with applicable FDA regulations and ICH-GCP guidelines for the conduct of Phase 4 post-marketing studies.