Changeflow GovPing Pharma & Drug Safety Trolox-peptide conjugate and use thereof
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Trolox-peptide conjugate and use thereof

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Published March 31st, 2026
Detected March 31st, 2026
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Summary

USPTO issued Patent Grant US12589064B2 to Caregen Co., Ltd. on March 31, 2026, covering a Trolox-peptide conjugate for hair loss prevention. The patented compound inhibits 5α-reductase activity, prevents papilla cell and keratinocyte death, promotes cell growth, and provides antioxidant effects. The patent contains 9 claims and names Yong Ji Chung, Eun Mi Kim, Eung Ji Lee, and Min Woong Kim as inventors.

What changed

The USPTO granted Patent US12589064B2 to Caregen Co., Ltd. for a Trolox-peptide conjugate with hair loss prevention applications. The patent (Application No. 17607115, filed May 6, 2020) claims a compound where Trolox and a peptide are chemically bonded, effective at inhibiting 5α-reductase, preventing cell death, promoting growth, and providing antioxidant activity. The grant confers exclusive intellectual property rights to the assignee.

Regulated entities do not need to take immediate compliance actions based on this patent grant. However, pharmaceutical and biotechnology companies developing hair loss treatments or 5α-reductase inhibitors should review this patent to assess potential freedom-to-operate concerns. Companies should ensure their R&D activities do not infringe on the granted claims and should consult with IP counsel regarding licensing opportunities if commercializing related products.

Source document (simplified)

← USPTO Patent Grants

Trolox-peptide conjugate and use thereof

Grant US12589064B2 Kind: B2 Mar 31, 2026

Assignee

Caregen Co., Ltd.

Inventors

Yong Ji Chung, Eun Mi Kim, Eung Ji Lee, Min Woong Kim

Abstract

The present invention relates to a Trolox-peptide conjugate having a structure in which Trolox and a peptide are chemically bonded. The Trolox-peptide conjugate not only very effectively inhibits the activity of 5α-reductase, but also inhibits the death of papilla cells and keratinocytes, promotes the growth thereof, and has antioxidative effects, and thus can remarkably promote hair formation while avoiding or preventing hair loss.

CPC Classifications

A61K 8/498 A61K 47/64 A61K 8/64 A61P 17/14 A61Q 7/00 C07K 7/06 C07K 7/08

Filing Date

2020-05-06

Application No.

17607115

Claims

9

View original document →

Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
USPTO
Published
March 31st, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12589064B2

Who this affects

Applies to
Pharmaceutical companies Drug manufacturers
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Geographic scope
United States US

Taxonomy

Primary area
Intellectual Property
Operational domain
Legal
Topics
Healthcare Pharmaceuticals

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