Cell Adhesion System for Interspecies Chimeras

ChangeBridge: Patent Apps - Biotech (C12N)

Published April 2nd, 2026

Detected April 2nd, 2026

Summary

USPTO published patent application US20260092259A1 by inventors Jun Wu, Emily B. Ballard, and Jia Huang for a cell adhesion system enabling formation of interspecies chimeras through engineered cells expressing antigen-binding proteins or antigens with cell membrane signaling peptides. The invention facilitates generation of organs, organoids, or tissue masses from human and non-human chimeric animals for potential transplant applications.

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What changed

The USPTO published application US20260092259A1 discloses a cell adhesion system for creating interspecies chimeras by engineering cells to co-express either an antigen-binding protein or an antigen with a cell membrane signaling peptide or cell membrane anchor protein. This modification enhances cell adhesion, improving the formation of chimeras combining cells from different mammalian species, including human and non-human combinations. The application covers methods for organogenesis to generate transplantable organs and tissues using these engineered populations.

This is a patent application publication, not a binding regulatory rule. No immediate compliance actions are required. Researchers, biotechnology companies, and pharmaceutical developers working on organ generation, xenotransplantation, or chimera technologies should monitor this application's prosecution status. The invention may affect R&D priorities in regenerative medicine and transplantable organ production once the patent proceeds to grant.

Source document (simplified)

← USPTO Patent Applications

CELL ADHESION SYSTEM FOR INTERSPECIES CHIMERAS

Application US20260092259A1 Kind: A1 Apr 02, 2026

Inventors

Jun Wu, Emily B. Ballard, Jia Huang

Abstract

Disclosures herein are directed to populations of cells comprising one or more cell of a first mammalian species and one or more cell of a second mammalian species, such as stem cells and embryos, wherein the cells are engineered to express an either an antigen-binding protein or an antigen, wherein each are expressed with a cell membrane signaling peptide and/or a cell membrane anchor protein. The inclusion of the cell membrane signaling peptide or a cell membrane anchor protein enhances cell adhesion, enabling improved formation of interspecies chimeras, for example the generation of a human and non-human interspecies chimera. Also provided herein are methods of manufacturing the population of cells as described herein. Also provided are methods of organogenesis to generate an organ, organoid, or tissue mass comprising an interspecies chimeric animal for organ transplant, and methods of treatment using the same.