Universal Peptide/MHC Complexes with Engineered Disulfide
Summary
The USPTO published patent application US20260097105A1 by Nikolaos SGOURAKIS for synthetic major histocompatibility complex (MHC) molecules featuring engineered disulfide linkages connecting heavy and light chains. The invention covers systems, formulations, and methods for generating universal peptide/MHC complexes using structure-guided modeling and design. Application No. 19114130 was filed September 28, 2023, with CPC classifications including A61K 39/001188, A61K 39/385, C07K 14/4748, and C07K 14/70539.
What changed
The USPTO published a patent application disclosing engineered synthetic MHC (major histocompatibility complex) molecules with engineered disulfide linkages between heavy and light chains. The invention enables generation of universal peptide/MHC complexes through structure-guided modeling and design. The CPC classifications indicate pharmaceutical and therapeutic applications, including A61P 35/00 (antineoplastic agents) and various A61K and C07K codes.
For biotechnology and pharmaceutical companies engaged in immunotherapy research, cancer therapeutics development, or T-cell receptor engineering, this patent application may signal competitive landscape considerations. The universal peptide/MHC platform with engineered disulfide linkages represents a specialized approach to immune-related therapeutic development.
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Archived snapshot
Apr 9, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
SYSTEMS, FORMULATIONS AND METHODS FOR GENERATING UNIVERSAL PEPTIDE/MHC COMPLEXES WITH ENGINEERED DISULFIDE CONNECTING THE HEAVY AND LIGHT CHAINS
Application US20260097105A1 Kind: A1 Apr 09, 2026
Inventors
Nikolaos SGOURAKIS
Abstract
The present invention relates to engineering synthetic major histocompatibility complex (MHC) molecules for generating universal peptide/MHC complexes with engineered disulfide linkage(s) using structure-guided modeling and design and method for making and using the same.
CPC Classifications
A61K 39/001188 A61K 39/001191 A61K 39/385 A61P 35/00 C07K 14/4748 C07K 14/70539 A61K 2039/605 C07K 2319/00
Filing Date
2023-09-28
Application No.
19114130
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