Stem cell-derived gastruloid model and construction method

ChangeBridge: Patent Apps - Biotech (C12N)

Detected March 27th, 2026

Summary

The USPTO has published a patent application detailing a stem cell-derived gastruloid model and its construction method. This model simulates early embryonic development and can be used for drug screening and safety testing, particularly for early pregnancy applications.

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What changed

This document is a USPTO patent application (US20260085283A1) for a stem cell-derived gastruloid model and its construction method. The model, created in vitro from human pluripotent stem cells, replicates key biological events and structures of early embryonic development from the peri-implantation to gastrula stages, verified at protein and transcriptome levels. It is intended for use as a drug screening model for early embryos and environmental toxicants, providing safety testing for drug use in early pregnancy.

As this is a patent application, it does not impose direct compliance obligations on regulated entities. However, it signals potential future innovations and intellectual property in the biotechnology and pharmaceutical sectors. Companies involved in drug development, particularly those focusing on reproductive health or requiring early-stage safety testing, should be aware of this technological development for competitive intelligence and potential licensing opportunities.

Source document (simplified)

← USPTO Patent Applications

STEM CELL-DERIVED GASTRULOID MODEL, METHOD FOR CONSTRUCTING SAME, AND USE

Application US20260085283A1 Kind: A1 Mar 26, 2026

Inventors

Jiahao SHA, Yan YUAN, Gege YUAN

Abstract

Provided are a stem cell-derived gastruloid model, method for constructing same, and use thereof. The gastruloid model is constructed in vitro from human pluripotent stem cells, and simulated the biological events of early embryonic development and the key structures of the embryo to a certain extent, such as the development of primitive endoderm, the establishment of bilaminar germ disc, the appearance of the amniotic cavity and amniotic cells, and the appearance of the primitive streak and the like, which has been verified at both the protein level and the transcriptome level, and the key features of embryos from the peri-implantation period to the gastrula period could be well reproduced. This model can be induced in batches as a drug screening model for early embryos and environmental toxicants and the like, thereby providing safety testing for the use of drugs for certain clinical patients in early pregnancy and so on.