Self-assembling peptide gel for tissue lift, repair
Summary
The USPTO published patent application US20260091159A1 by Norchi et al. disclosing compositions containing self-assembling peptides that form stable in situ gels for tissue lift, repair, and bulking applications. The formulations are designed for use during endoscopic, laparoscopic, or open surgical procedures and provide hemostatic properties with adhesion prevention for periods of days to one month.
What changed
The USPTO published patent application US20260091159A1 for a self-assembling peptide gel formulation invented by Terrence Norchi, Chirag Shah, and Rutledge Ellis-Behnke. The application (No. 19272262, filed July 17, 2025) covers compositions of self-assembling peptides and peptidomimetics that form stable in situ gels lasting from days to a month. The formulations serve as tissue lift agents, bulking agents, or tissue-forming matrices with hemostatic and anti-adhesion properties for use in surgical procedures.
Medical device manufacturers and pharmaceutical companies developing biomaterials for surgical applications should review this patent publication to assess potential freedom-to-operate considerations or licensing opportunities. Researchers in tissue engineering and regenerative medicine may find relevant prior art or technology foundations. No compliance deadlines or regulatory responses are required for this patent publication.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
SELF-ASSEMBLING PEPTIDE GEL FORMULATION AND METHODS OF USE
Application US20260091159A1 Kind: A1 Apr 02, 2026
Inventors
Terrence Norchi, Chirag Shah, Rutledge Ellis-Behnke
Abstract
Compositions containing self-assembling peptides and/or self-assembling peptidomimetics (“self-assembling peptides”) can be used to create a long-lasting “lift” or means of elevating tissue to be resected, dissected, manipulated or repaired, as a bulking agent, or as a tissue forming matrix by injection of a solution that forms a solid gel in situ, which is stable for a prolonged period of time from days to a month, is hemostatic, and may prevent adhesions. These self-assembling peptides and methods of use thereof enable better separation of tissues and visualization of margins, more durable and robust lifts, less need for frequent injections that carry risk of undesired perforation, and simultaneous management of adverse effects, such as bleeding, leaking, inflammation and iatrogenic injury during endoscopic, laparoscopic or other minimally invasive, or open surgical procedures in and/or on the body.
CPC Classifications
A61L 27/22 A61L 27/52 A61L 27/58 C07K 7/08 A61L 2400/04 A61L 2400/06 C07K 2319/735
Filing Date
2025-07-17
Application No.
19272262
Named provisions
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