Patent Application: Production Method for Product to Prevent Membrane Clogging

ChangeBridge: Patent Apps - Peptides (C07K)

Published November 28th, 2025

Detected March 26th, 2026

Summary

The USPTO has published a patent application from FUJIFILM Corporation detailing a production method for a product that aims to prevent membrane clogging during cell culture. The method involves specific mathematical expressions related to poloxamer concentration, product concentration, and hydrophobicity index to optimize the cell culture process.

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What changed

This document is a published patent application (US20260085110A1) from FUJIFILM Corporation, filed on November 28, 2025. It describes a novel production method for a product intended to prevent membrane clogging and maintain productivity during cell culture. The core of the invention lies in satisfying specific mathematical conditions related to the concentration of poloxamer (P), product (C), hydrophobicity index (S), and valine residue ratio (V) in the culture solution, as defined by Expression 1 and Expression 5.

As this is a patent application, it does not impose immediate regulatory obligations or penalties on entities. However, companies involved in cell culture-based production, particularly in the pharmaceutical and biotechnology sectors, may find this method relevant for optimizing their manufacturing processes. Compliance officers should note this as a potential technological advancement in the field, which could influence future industry standards or practices. No specific compliance deadline or action is required based on this publication alone.

Source document (simplified)

← USPTO Patent Applications

PRODUCTION METHOD FOR PRODUCT

Application US20260085110A1 Kind: A1 Mar 26, 2026

Assignee

FUJIFILM Corporation

Inventors

Shinichi NAKAI, Atsushi INADA, Katsuhiro SHIMONO, Shino OHIRA, Noriyuki OHASHI, Yuanzhong LI, Ichihiko HASHIMOTO

Abstract

An object of the present invention is to provide a method that makes it possible to prevent clogging of a membrane during culture and prevent a decrease in productivity in a production method for a product by cell culture. According to the present invention, there is provided a production method for a product, including: culturing cells in a culture solution, in which, in a case where a poloxamer concentration in the culture solution is denoted by P (g/L), a product concentration in the culture solution is denoted by C (g/L), a hydrophobicity index SAP value of the product is denoted by S, and a ratio of a valine residue of an L chain variable region of the product is denoted by V (%), at least one of 1.5P+3C+0.93S≤378 (Expression 1) or P+3.5C+1.9V≤29 (Expression 5) is satisfied.