PRODUCTION METHOD FOR PRODUCT

Abstract

An object of the present invention is to provide a method that makes it possible to prevent clogging of a membrane during culture and prevent a decrease in productivity in a production method for a product by cell culture. According to the present invention, there is provided a production method for a product, including: culturing cells in a culture solution, in which, in a case where a poloxamer concentration in the culture solution is denoted by P (g/L), a product concentration in the culture solution is denoted by C (g/L), a hydrophobicity index SAP value of the product is denoted by S, and a ratio of a valine residue of an L chain variable region of the product is denoted by V (%), at least one of 1.5P+3C+0.93S≤378 (Expression 1) or P+3.5C+1.9V≤29 (Expression 5) is satisfied.

CPC Classifications