EPO Patent Promotes Hypoxia for Treating Mitochondrial Dysfunction

ChangeBridge: EPO Bulletin - Therapeutics (A61P)

Published March 18th, 2026

Detected March 25th, 2026

Summary

The European Patent Office has published patent application EP4512819A2, detailing compositions and methods that promote hypoxia for treating mitochondrial dysfunction and oxidative stress disorders. The patent is assigned to The General Hospital Corporation and Massachusetts Institute of Technology.

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What changed

This document announces the publication of European patent application EP4512819A2 by the European Patent Office (EPO). The patent, assigned to The General Hospital Corporation and Massachusetts Institute of Technology, covers "Compositions and Methods that Promote Hypoxia or the Hypoxia Response for Treatment and Prevention of Mitochondrial Dysfunction and Oxidative Stress Disorders." The publication date is March 18, 2026.

This is a patent publication, not a regulatory rule or guidance with direct compliance obligations for regulated entities. It signifies the granting of intellectual property rights for a specific therapeutic approach. Companies in the pharmaceutical and biotechnology sectors may wish to review this patent for potential licensing opportunities or to understand the competitive landscape in treating mitochondrial dysfunction and oxidative stress.

Source document (simplified)

← EPO Patent Bulletin

COMPOSITIONS AND METHODS THAT PROMOTE HYPOXIA OR THE HYPOXIA RESPONSE FOR TREATMENT AND PREVENTION OF MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE STRESS DISORDERS

Publication EP4512819A2 Kind: A2 Mar 18, 2026

Applicants

The General Hospital Corporation, Massachusetts Institute of Technology

Inventors

MOOTHA, Vamsi K., JAIN, Isha, ZAPOL, Warren M., ZAZZERON, Luca

IPC Classifications

A61K 33/00 20060101AFI20250702BHEP C07K 14/00 20060101ALI20250702BHEP A61K 45/06 20060101ALI20250702BHEP A61P 3/10 20060101ALI20250702BHEP A61P 9/00 20060101ALI20250702BHEP A61P 9/10 20060101ALI20250702BHEP A61P 17/00 20060101ALI20250702BHEP A61P 25/00 20060101ALI20250702BHEP A61P 25/16 20060101ALI20250702BHEP A61P 25/28 20060101ALI20250702BHEP A61P 39/00 20060101ALI20250702BHEP A61P 43/00 20060101ALI20250702BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

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Named provisions

Compositions and Methods that Promote Hypoxia or the Hypoxia Response for Treatment and Prevention of Mitochondrial Dysfunction and Oxidative Stress Disorders