Ikaros Zinc Finger Degraders and Uses Thereof

ChangeBridge: EPO Bulletin - Organic Chemistry (C07D)

Published March 25th, 2026

Detected April 2nd, 2026

Summary

The European Patent Office published Gilead Sciences' patent application EP4452414A2 for Ikaros zinc finger family degraders and their therapeutic uses. The patent covers heterocyclic compounds (C07D) with applications in cancer treatment (A61P 35/00). Designated states include all EU member states plus additional European countries.

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What changed

The EPO published Gilead Sciences' patent EP4452414A2 for Ikaros zinc finger family degraders and uses thereof on March 25, 2026. The patent covers heterocyclic compounds classified under multiple C07D subclasses and specifies therapeutic uses primarily for cancer treatment (A61P 35/00). The designated contracting states include all EU member states along with other European countries.

This is a routine patent publication with no compliance obligations. Competitors developing targeted protein degradation therapies should review the patent claims for freedom-to-operate considerations. The patent establishes intellectual property protection for Gilead's degrader compounds but does not create regulatory requirements for other market participants.

Source document (simplified)

← EPO Patent Bulletin

IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF

Publication EP4452414A2 Kind: A2 Mar 25, 2026

Applicants

GILEAD SCIENCES, INC.

Inventors

BALAN, Gayatri, BLOMGREN, Peter A., CODELLI, Julian A., DU, Zhimin, KIM, Musong, THOMAS-TRAN, Rhiannon, TUDESCO, Michael T., VENKATARAMANI, Chandrasekar

IPC Classifications

A61P 35/00 20060101AFI20260218BHEP C07D 401/04 20060101ALI20260218BHEP C07D 401/12 20060101ALI20260218BHEP C07D 401/14 20060101ALI20260218BHEP C07D 405/14 20060101ALI20260218BHEP C07D 471/08 20060101ALI20260218BHEP A61K 31/454 20060101ALI20260218BHEP A61K 31/4545 20060101ALI20260218BHEP A61K 31/4748 20060101ALI20260218BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

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