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Patent Application for Cancer Treatment with Azenosertib and HRD Biomarker

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Published December 1st, 2025
Detected March 26th, 2026
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Summary

The USPTO has published a patent application (US20260083742A1) detailing methods for treating cancer by administering azenosertib to subjects selected based on homologous recombination repair deficiency (HRD). The application was filed on December 1, 2025.

What changed

This document is a patent application (US20260083742A1) filed with the USPTO on December 1, 2025. It describes methods for treating cancer by administering azenosertib, a WEE1 inhibitor, to patients identified as having homologous recombination repair deficiency (HRD), which is proposed as a predictive biomarker. The application lists several inventors and includes CPC classifications related to pharmaceutical compositions and disease treatment.

As this is a patent application, it does not impose direct regulatory obligations on companies. However, it signifies potential future intellectual property and market exclusivity for a specific cancer treatment approach. Companies involved in oncology drug development, particularly those working with WEE1 inhibitors or HRD biomarkers, should be aware of this filing for competitive intelligence and potential licensing or collaboration opportunities.

Source document (simplified)

← USPTO Patent Applications

HOMOLOGOUS RECOMBINATION REPAIR DEFICIENCY (HRD) AS A PREDICTIVE BIOMARKER FOR TREATING CANCER WITH WEE1 INHIBITORS

Application US20260083742A1 Kind: A1 Mar 26, 2026

Inventors

Jianhui Ma, Olivier Harismendy, Jiali Li, Ahmed Abdi Samatar, Samuel DePrimo, Catherine Lee, Monah Abed

Abstract

The present disclosure provides, among other things, methods for treating cancer comprising administering an effective dose of azenosertib, or a pharmaceutically acceptable salt thereof, to subjects selected to have a homologous recombination repair deficiency (HRD).

CPC Classifications

A61K 31/519 A61K 31/454 A61K 31/496 A61K 31/502 A61P 35/00

Filing Date

2025-12-01

Application No.

19404321

View original document →

Named provisions

HOMOLOGOUS RECOMBINATION REPAIR DEFICIENCY (HRD) AS A PREDICTIVE BIOMARKER FOR TREATING CANCER WITH WEE1 INHIBITORS

Classification

Agency
USPTO
Published
December 1st, 2025
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US20260083742A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Activity scope
Drug Development Cancer Treatment
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Research & Development
Topics
Oncology Biomarkers

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