Patent Application for Cancer Treatment with Azenosertib and HRD Biomarker
Summary
The USPTO has published a patent application (US20260083742A1) detailing methods for treating cancer by administering azenosertib to subjects selected based on homologous recombination repair deficiency (HRD). The application was filed on December 1, 2025.
What changed
This document is a patent application (US20260083742A1) filed with the USPTO on December 1, 2025. It describes methods for treating cancer by administering azenosertib, a WEE1 inhibitor, to patients identified as having homologous recombination repair deficiency (HRD), which is proposed as a predictive biomarker. The application lists several inventors and includes CPC classifications related to pharmaceutical compositions and disease treatment.
As this is a patent application, it does not impose direct regulatory obligations on companies. However, it signifies potential future intellectual property and market exclusivity for a specific cancer treatment approach. Companies involved in oncology drug development, particularly those working with WEE1 inhibitors or HRD biomarkers, should be aware of this filing for competitive intelligence and potential licensing or collaboration opportunities.
Source document (simplified)
HOMOLOGOUS RECOMBINATION REPAIR DEFICIENCY (HRD) AS A PREDICTIVE BIOMARKER FOR TREATING CANCER WITH WEE1 INHIBITORS
Application US20260083742A1 Kind: A1 Mar 26, 2026
Inventors
Jianhui Ma, Olivier Harismendy, Jiali Li, Ahmed Abdi Samatar, Samuel DePrimo, Catherine Lee, Monah Abed
Abstract
The present disclosure provides, among other things, methods for treating cancer comprising administering an effective dose of azenosertib, or a pharmaceutically acceptable salt thereof, to subjects selected to have a homologous recombination repair deficiency (HRD).
CPC Classifications
A61K 31/519 A61K 31/454 A61K 31/496 A61K 31/502 A61P 35/00
Filing Date
2025-12-01
Application No.
19404321
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