Patent Application for Benzofuran Derivatives as SIK Inhibitors

ChangeBridge: Patent Apps - Organic Chemistry (C07D)

Detected March 26th, 2026

Summary

The USPTO has published a patent application (US20260085053A1) from BEONE MEDICINES I GMBH for benzofuran derivatives that act as SIK inhibitors. These compounds are intended for the treatment of various inflammatory diseases.

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What changed

This document is a published patent application detailing novel benzofuran derivatives designed as salt-inducible kinase (SIK) inhibitors. The application, filed by BEONE MEDICINES I GMBH, includes specific compound structures (formula I) and outlines their potential use in treating inflammatory diseases. The application number is 19405502, and it was filed on December 2, 2025.

As this is a patent application, it does not impose immediate regulatory obligations on companies. However, it signals potential future developments in pharmaceutical research and development for inflammatory conditions. Companies operating in the pharmaceutical sector, particularly those involved in drug discovery and development for inflammatory diseases, should be aware of this filing as it may impact future intellectual property landscapes and competitive research efforts.

Source document (simplified)

← USPTO Patent Applications

BENZOFURAN DERIVATIVES AS SIK INHIBITORS AND THE USE THEREOF

Application US20260085053A1 Kind: A1 Mar 26, 2026

Assignee

BEONE MEDICINES I GMBH

Inventors

Jing Li, Fengtao Song, Zhiwei Wang

Abstract

Provided are compounds of formula (I) as well as their compositions and methods of use, wherein values for variables R1, R2, R5, X, X1, and X2 are provided herein. The compounds inhibit salt-inducible kinase activity and are useful in the treatment of various inflammatory diseases.

CPC Classifications

C07D 307/83 A61K 31/343 A61K 31/351 A61K 31/397 A61K 31/4025 A61K 31/403 A61K 31/4035 A61K 31/404 A61K 31/4155 A61K 31/4178 A61K 31/422 A61K 31/4245 A61K 31/438 A61K 31/443 A61K 31/4525 A61K 31/454 A61K 31/4709 A61K 31/4725 A61K 31/496 A61K 31/501 A61K 31/506 A61K 31/5377 A61K 31/538 A61K 31/553 C07D 405/04 C07D 405/12 C07D 405/14 C07D 407/12 C07D 413/12 C07D 413/14 C07D 471/10 C07D 491/048