Changeflow GovPing Pharma & Drug Safety Anti-Henipavirus Monoclonal Antibodies with Bro...
Routine Notice Added Final

Anti-Henipavirus Monoclonal Antibodies with Broad Spectrum Neutralization

Favicon for changeflow.com ChangeBridge: Patent Grants - Peptides (C07K)
Published March 31st, 2026
Detected March 31st, 2026
Email

Summary

The USPTO granted Patent US12590141B2 to the Academy of Military Medical Science covering monoclonal antibodies targeting Henipavirus glycoprotein G. The patent claims antibodies combining macaque variable regions with human constant regions, demonstrating broad neutralization activity against Nipah and Hendra viruses. The patent includes 9 claims and covers encoding nucleic acids for therapeutic applications.

What changed

USPTO issued Patent US12590141B2 to the Academy of Military Medical Science, PLA, for anti-Henipavirus monoclonal antibodies with broad spectrum neutralization activity. The patent covers antibodies comprising macaque variable regions and human constant regions, with binding activity to both Nipah virus and Hendra virus glycoprotein G. The granted patent includes 9 claims covering the antibody compositions and encoding nucleic acids for treating Henipavirus diseases. Filing date was June 27, 2021, under Application No. 18005979.

This patent grant conveys intellectual property rights to the Academy of Military Medical Science. Pharmaceutical companies or researchers developing Henipavirus therapeutics should assess potential licensing needs or design-around considerations. No compliance deadlines or regulatory actions are triggered by this patent issuance.

Source document (simplified)

← USPTO Patent Grants

Monoclonal antibodies against Henipavirus glycoprotein G and encoding nucleic acids thereof

Grant US12590141B2 Kind: B2 Mar 31, 2026

Assignee

Academy of Military Medical Science, PLA

Inventors

Wei Chen, Changming Yu, Yujiao Liu, Pengfei Fan, Guanying Zhang, Yaohui Li, Jianmin Li, Xiangyang Chi, Meng Hao, Ting Fang, Yunzhu Dong, Xiaohong Song, Yi Chen, Shuling Liu

Abstract

Provided is an anti-Henipavirus monoclonal antibody having broad spectrum neutralization activity, wherein the antibody comprises a macaque variable region and a human constant region. The antibody of the present invention has good binding activity to both Nipah virus glycoprotein G and Hendra virus glycoprotein G, can effectively neutralize Nipahpseudovirus and Hendra pseudovirus, and can be used for preparing drugs for treating Henipavirus diseases.

CPC Classifications

A61P 31/14 C07K 16/10 C07K 16/1027 C07K 2317/24 C07K 2317/33 C07K 2317/76 C07K 2317/92 C07K 2317/21 C07K 2317/52 C07K 2317/565

Filing Date

2021-06-27

Application No.

18005979

Claims

9

View original document →

Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
USPTO
Published
March 31st, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12590141B2

Who this affects

Applies to
Pharmaceutical companies Drug manufacturers
Industry sector
3254 Pharmaceutical Manufacturing
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Healthcare Public Health

Get Pharma & Drug Safety alerts

Weekly digest. AI-summarized, no noise.

Free. Unsubscribe anytime.

Get alerts for this source

We'll email you when ChangeBridge: Patent Grants - Peptides (C07K) publishes new changes.

Optional. Personalizes your daily digest.

Free. Unsubscribe anytime.