Monoclonal antibodies against Henipavirus glycoprotein G and encoding nucleic acids thereof
Grant
US12590141B2
Kind: B2
Mar 31, 2026
Assignee
Academy of Military Medical Science, PLA
Inventors
Wei Chen, Changming Yu, Yujiao Liu, Pengfei Fan, Guanying Zhang, Yaohui Li, Jianmin Li, Xiangyang Chi, Meng Hao, Ting Fang, Yunzhu Dong, Xiaohong Song, Yi Chen, Shuling Liu
Abstract
Provided is an anti-Henipavirus monoclonal antibody having broad spectrum neutralization activity, wherein the antibody comprises a macaque variable region and a human constant region. The antibody of the present invention has good binding activity to both Nipah virus glycoprotein G and Hendra virus glycoprotein G, can effectively neutralize Nipahpseudovirus and Hendra pseudovirus, and can be used for preparing drugs for treating Henipavirus diseases.
CPC Classifications
A61P 31/14
C07K 16/10
C07K 16/1027
C07K 2317/24
C07K 2317/33
C07K 2317/76
C07K 2317/92
C07K 2317/21
C07K 2317/52
C07K 2317/565
Filing Date
2021-06-27
Application No.
18005979
Claims
9